Pharmacokinetic modifications of immediate release tablets of raloxifene hydrochloride by hot melt technology

Palanisamy, Ponnusamy; Jaykar, B.; Chandira, Margret; Venkateswarlu, B. S.; Prabakaran, M

doi:10.5958/0974-360x.2020.00723.4

Cited by 2 publications

(1 citation statement)

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“…For many years, oral drug delivery has been recognized as the most commonly used method of administering drugs for systemic effects (1) Due to its simplicity, high patient acceptance, and cost-effective manufacturing process (2). Immediate-release tablets (IRT) are ones designed to be ingested as a whole and disintegrate quickly in the gastrointestinal tract, allowing for rapid release of the drug (3).…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Immediate-Release Tablet Containing Atorvastatin Phospholipid Solid Dispersion

K. K. GHYADH,

KHEDAIRY

2024

jrp

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Oral tablets containing solubilized drug in the presence of appropriate excipients may give us an immediate release of the drug. Phospholipid solid dispersion (PSD) is a branch of solid dispersion in which phospholipid acts as a hydrophilic polymer in the presence of a suitable adsorbent to enhance the solubility of poorly soluble drugs. The anti-hyperlipidemic drug Atorvastatin (ATR) is an example of such drug, as it belongs to the class II group according to the biopharmaceutical classification system (BCS) with low bioavailability due to its low solubility. Phosphatidylcholine in combination with magnesium aluminum silicate as an adsorbent in a ratio of ATR: PC: MAS 1:3:4 was used to prepare ATR PSD by the solvent evaporation method, the product showed acceptable physical properties and utilized for the preparation of immediate-release tablets (IRTs) of ATR. Ten formulas of ATR-IRTs were prepared by direct compression method using different types and concentrations of diluents (Avicel ® PH102, Avicel ® PH101, and starch) and superdisintegrants (crospovidone, croscarmellose sodium, and sodium starch glycolate) and evaluated for their drug content, weight variation, hardness, friability, in vitro disintegration time and dissolution profile. The tablets formula (T10) that were prepared with ATR-PSD and Avicel ® PH102 as a diluent and Croscarmellose Sodium (CCS) 5% w/w as super disintegrant show the shortest disintegration time (DT) (38 ±1 sec.) and best drug release (91% within 15 min) in 0.05M phosphate buffer (pH 6.8).

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Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Immediate-Release Tablet Containing Atorvastatin Phospholipid Solid Dispersion

K. K. GHYADH,

KHEDAIRY

2024

jrp

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Injectable hydrogel scaffolds composed of Nanocellulose derived from sugarcane bagasse and combined with calcium for Bone regeneration

Kamel,

El-Wakil,

A. Elkasabgy

2023

RJPT

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Injectable in-situ forming hydrogel scaffolds (IHS) were prepared using TEMPO-oxidized nanofibrillated cellulose (TONFC) originating from sugarcane bagasse. TONFC (0.5%w/w) was prepared and characterized, then various concentrations of poloxamer 407 (P407) were added to prepare the thermo-responsive hydrogels. Two sources of calcium; Fujicalin® (DCP) or Hydroxyapatite (TCP), were utilized to prepare the calcium-enriched HIS loaded with the antiresorptive drug raloxifene hydrochloride. Physicochemical evaluation comprising the gelation temperature, drug content, injectability and in-vitro drug release were performed in addition to the examination of the morphological characters. The chosen formulation 'Ca-IHS4' consisted of TONFC, 15% P407 and 10% TCP displayed the most extended release pattern (for 12 days) with the smallest burst effect. SEM images of the in-situ formed scaffolds presented a highly porous 3D structure essential for cells migration, nutrient transport and tissue infiltration. Cell biology studies were performed using Saos-2 cells and proved that “Ca-IHS4” is biocompatible and has cell regenerative effect. These findings suggest that Ca-IHS4 presents a simple, safe and non-invasive platform for bone regeneration.

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Pharmacokinetic modifications of immediate release tablets of raloxifene hydrochloride by hot melt technology

Cited by 2 publications

References 0 publications

Formulation and Evaluation of Immediate-Release Tablet Containing Atorvastatin Phospholipid Solid Dispersion

Formulation and Evaluation of Immediate-Release Tablet Containing Atorvastatin Phospholipid Solid Dispersion

Injectable hydrogel scaffolds composed of Nanocellulose derived from sugarcane bagasse and combined with calcium for Bone regeneration

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