Pharmacokinetic parameters of Amoxicillin in Bangladeshi volunteers: a preliminary evaluation

Chowdhury, Reefat Zaman; Islam, Md. Saiful; Rahman, Md. Shafiqur

doi:10.3329/bjpp.v26i1-2.19958

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…The pharmacokinetic status of Bangladeshi population is still not very clearly understood, though couple of studies revealed that orally administered medicines achieve adequate concentration to demonstrate desired pharmacological effects (Chowdhury et al, 2010;Chowdhury et al, 2011;Chowdhury et al, 2014). The present study was not designed to ascertain or clarify the correlation of kinetics with dynamics.…”

Section: Discussionmentioning

confidence: 99%

Strength, efficacy and tolerability of morphine solution with and without added preservatives: A comparative study

Perveen

Rahman

2015

Bangladesh J Pharmacol

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Section: Discussionmentioning

confidence: 99%

Strength, efficacy and tolerability of morphine solution with and without added preservatives: A comparative study

Perveen

Rahman

2015

Bangladesh J Pharmacol

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“…Though some initiative and effort was made towards understanding the pharmacokinetics of antimicrobials in Bangladeshi children 22 and adult population [23][24] , very little development has been achieved. There were different challenges like selection of volunteers, laboratory facilities, establishment of laboratory methods and hospitalization of volunteers, for which this type of pharmacokinetic study could not be conducted before in this region.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic study after single oral dose of beta-lactam and fluoroquinolone antimicrobials in Bangladeshi healthy male volunteers

Chowdhury

Islam

Rahman

2014

Bangladesh J Physiol Pharmacol

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The variability of response to antimicrobial has been inadequately explained because of lack of pharmacokinetic data. The present pharmacokinetic study was designed to provide information beneficial to formulate a population pharmacokinetic model appropriate for Bangladeshi population. Among the beta-lactams, amoxicillin (500 mg), flucloxacillin (250 mg), cefuroxime (500 mg) and among the fluoroquinolones, ciprofloxacin (500 mg), levofloxacin (500 mg), gatifloxacin (400 mg) were studied in 15 healthy Bangladeshi male volunteers. The Cmax, AUC0infinity, Tmax, T1/2 and Ctrough were studied with all antimicrobials. Later, the Cmax and AUC0infinity were adjusted for bodyweight and dose. Among the studied antimicrobials, the Cmax varied to great extent even after adjustment for bodyweight and dose. The Cmax after adjustment was highest in case of flucloxacillin and lowest in case of ciprofloxacin, indicating excellent absorption of flucloxacillin in Bangladeshi population. The information obtained through this study generates necessity of new cut-off value for the antimicrobials.DOI: http://dx.doi.org/10.3329/bjpp.v30i1.20789 Bangladesh J Physiol Pharmacol 2014; 30(1):16-24

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Pharmacokinetic Parameters of Ciprofloxacin in Bangladeshi Volunteers: A Preliminary Evaluation

Chowdhury

Islam

Rahman

2014

Bangladesh J Physiol Pharmacol

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The present study has attempted to establish a High-performance liquid chromatography (HPLC) method to determine ciprofloxacin in plasma, in order to evaluate the bioavailability of ciprofloxacin. In this study, initially 8 (eight) Bangladeshi Bangalee healthy male volunteers and 7 (seven) Bangladeshi Tribal healthy male volunteers received 500 mg tablet of pioneer brand of ciprofloxacin in oral route. Blood samples were collected at 0, 30, 60, 120, 180, 360, 540 and 720 minutes after drug administration. After 1 week of washout period, same volunteers of two groups received 200 mg injection of pioneer brand of ciprofloxacin in intravenous route. HPLC with ultraviolet detection was used to quantify plasma ciprofloxacin concentrations.

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Pharmacokinetic parameters of Amoxicillin in Bangladeshi volunteers: a preliminary evaluation

Abstract: ABSTRACT

Cited by 3 publications

References 26 publications

Strength, efficacy and tolerability of morphine solution with and without added preservatives: A comparative study

Strength, efficacy and tolerability of morphine solution with and without added preservatives: A comparative study

Pharmacokinetic study after single oral dose of beta-lactam and fluoroquinolone antimicrobials in Bangladeshi healthy male volunteers

Pharmacokinetic Parameters of Ciprofloxacin in Bangladeshi Volunteers: A Preliminary Evaluation

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