Pharmacokinetic–pharmacodynamic study of itraconazole in patients with fungal infections in intensive care units

Hagihara, Mao; Kasai, Hidefumi; Umemura, Takumi; Kato, Takahiro; Hasegawa, Takaaki; Mikamo, Hiroshige

doi:10.1007/s10156-010-0102-4

Cited by 7 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More importantly, the dissemination was controlled much better by cross‐linked micelles, according to the histopathological analysis (Figure ). This result was in good agreement with the PK characteristics of cross‐linked or non‐cross‐linked micelles, owing to the antifungal effect of ITZ was dependent on its plasma concentration and AUC …”

Section: Resultssupporting

confidence: 84%

Functionalized Nanoscale Micelles with Brain Targeting Ability and Intercellular Microenvironment Biosensitivity for Anti‐Intracranial Infection Applications

Shao

Zhang

Ding

et al. 2014

Adv Healthcare Materials

View full text Add to dashboard Cite

Due to complication factors such as blood-brain barrier (BBB), integrating high efficiency of brain target ability with specific cargo releasing into one nanocarrier seems more important. A brain targeting nanoscale system is developed using dehydroascorbic acid (DHA) as targeting moiety. DHA has high affinity with GLUT1 on BBB. More importantly, the GLUT1 transportation of DHA represents a "one-way" accumulative priority from blood into brain. The artificial micelles are fabricated by a disulfide linkage, forming a bio-responsive inner barrier, which can maintain micelles highly stable in circulation and shield the leakage of entrapped drug before reaching the targeting cells. The designed micelles can cross BBB and be further internalized by brain cells. Once within the cells, the drug release can be triggered by high intracellular level of glutathione (GSH). Itraconazole (ITZ) is selected as the model drug because of its poor brain permeability and low stability in blood. It demonstrates that the functionalized nanoscale micelles can achieve highly effective direct drug delivery to targeting site. Based on the markedly increased stability in blood circulation and improved brain delivery efficiency of ITZ, DHA-modified micelles show highly effective in anti-intracranial infection. Therefore, this smart nanodevice shows a promising application for the treatment of brain diseases.

show abstract

Section: Resultssupporting

confidence: 84%

Functionalized Nanoscale Micelles with Brain Targeting Ability and Intercellular Microenvironment Biosensitivity for Anti‐Intracranial Infection Applications

Shao

Zhang

Ding

et al. 2014

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…The half-life of itraconazole is 24 hours, and the time to reach steady state for itraconazole and hydroxyitraconazole may take up to 1 to 2 weeks, delaying the time to early TDM intervention. Dose-dependent pharmacokinetics have been observed within the normal dosing range (100-400 mg/day) with significant intrapatient and interpatient variability recently reported within several patient cohorts [51][52][53].…”

Section: Itraconazolementioning

confidence: 96%

Update on Antifungal Drug Dosing and Therapeutic Drug Monitoring

Trifilio

2011

Curr Fungal Infect Rep

View full text Add to dashboard Cite

The prevention and treatment of invasive fungal infections can be compromised by antifungal agents that display unpredictable pharmacokinetics and significant drug interactions and which demonstrate a strong relationship between drug exposure and efficacy and toxicity. Clinical studies have shown that maintaining antifungal drug levels within a targeted range decreases the risk for treatment failure and drug toxicity and thus have established a role for therapeutic drug monitoring with the use of various agents. Evidence from experimental and clinical studies supporting the role of therapeutic drug monitoring and practical applications for attaining targeted levels are reviewed.

show abstract

“…In a retrospective PK/PD analysis (10 patients receiving at least four doses), a total AUC 0-24 >30 mg h/L was associated with optimal antifungal efficacy [39]. However, in ca.…”

Section: Critically Ill Patients With Normal Renal Functionmentioning

confidence: 98%

Using pharmacokinetics and pharmacodynamics to optimise dosing of antifungal agents in critically ill patients: a systematic review

Sinnollareddy

Peake

Roberts

et al. 2012

International Journal of Antimicrobial Agents

View full text Add to dashboard Cite

Pharmacokinetic–pharmacodynamic study of itraconazole in patients with fungal infections in intensive care units

Cited by 7 publications

References 31 publications

Functionalized Nanoscale Micelles with Brain Targeting Ability and Intercellular Microenvironment Biosensitivity for Anti‐Intracranial Infection Applications

Functionalized Nanoscale Micelles with Brain Targeting Ability and Intercellular Microenvironment Biosensitivity for Anti‐Intracranial Infection Applications

Update on Antifungal Drug Dosing and Therapeutic Drug Monitoring

Using pharmacokinetics and pharmacodynamics to optimise dosing of antifungal agents in critically ill patients: a systematic review

Contact Info

Product

Resources

About