Pharmacokinetic profile of a new form of sumatriptan tablets in healthy volunteers

Abstract

The new form of sumatriptan is bioequivalent to sumatriptan conventional tablets and is absorbed more quickly than conventional tablets.

Effects of a fast disintegrating/ rapid release oral formulation of sumatriptan on functional ability in patients with migraine

“…This study assessed the effects on functional ability of a new oral sumatriptan formulation developed with the goal of facilitating rapid attainment of pain-free response and restoration of functioning with an oral tablet, which is patients' preferred dosing form [10][11][12]27,28 . The new fast disintegrating/rapid release formulation may offer improved absorption over conventional tablets in the context of the gastric stasis that can accompany migraine because the new tablet depends less on gastric motility to facilitate disintegration and drug dispersion 29 . Because of the marked improvement in disintegration time and dispersion with the new formulation, a 4-to 5-fold improvement in the dissolution rate for sumatriptan is achieved with the new form compared with the conventional tablet 15 .…”

“…The new fast disintegrating/rapid release formulation may offer improved absorption over conventional tablets in the context of the gastric stasis that can accompany migraine because the new tablet depends less on gastric motility to facilitate disintegration and drug dispersion 29 . Because of the marked improvement in disintegration time and dispersion with the new formulation, a 4-to 5-fold improvement in the dissolution rate for sumatriptan is achieved with the new form compared with the conventional tablet 15 . Pharmacokinetic parameters measured early (0-2 h) after dosing reveal slightly faster absorption, on average, of the new sumatriptan formulation than sumatriptan conventional tablets, although high intersubject variability was observed 15 .…”

“…A new oral form of the 5HT 1B/1D agonist sumatriptan has been developed to facilitate tablet disintegration and drug dispersion and to mitigate the effects of gastric stasis that can accompany migraine 15 . A randomized, double-blind, placebo-controlled study was conducted to assess the efficacy and tolerability of this new fast disintegrating/rapid release sumatriptan formulation in patients practicing early intervention (i.e., treating a migraine attack early in its course while pain was still mild), a strategy that increases the likelihood of a pain-free response compared with the approach of delaying treatment until the pain has progressed to moderate or severe [16][17][18] .…”

Tablets and Other Solid Dosage Forms for Systemic Oral Mucosal Drug Delivery

“…This fast ODT also helps alleviate the effects of gastric stasis that may accompany migraine. The ODT formulation of sumatriptan is bioequivalent to sumatriptan conventional tablets and is absorbed more quickly than conventional tablets (highest sumatriptan plasma levels were attained, on average, 10 min earlier (50 mg) and 15 min earlier (100 mg) compared with the conventional tablet) [35]. Two studies were conducted comparing the time to onset of relief from moderate to severe migraine pain with the ODT formulation of sumatriptan tablets 50 mg and 100 mg and placebo.…”

Non-oral formulations of triptans and their use in acute migraine

“…In some countries, sumatriptan also is available in a suppository form (available in 12.5-and 25-mg strengths). The latest sumatriptan innovation, a fast-disintegrating/rapid-release oral tablet, recently has been introduced into clinical practice [45,46]. Swallowed with liquid, sumatriptan fastdisintegrating/rapid-release tablets were formulated to disintegrate and disperse efficiently in the gastrointestinal tract.…”