“…The streptokinase-plasmin(ogen) complex formed by streptokinase in plasma is subject to neutralisation by plasma protease inhibitors, and this process contributes to its rapid clearance in vivo (3,4,7). Reversible, active centre acylation of the preformed complex in EMINASE* protects the molecule from inhibition (and also from autoproteolysis) and allows it to circulate for prolonged periods as a potentially active species (3)(4)(5)(6). Deacylation of the complex generates active material over a period of time determined by the deacylation rate of the agent, such that fibrinolysis is maintained for several hours (4,6,7).…”