Pharmacokinetic Serum Concentrations of VRC01 Correlate with Prevention of HIV-1 Acquisition

Seaton, Kelly E.; Huang, Yunda; Karuna, Shelly; Heptinstall, Jack; Brackett, Caroline; Chiong, Kelvin; Zhang, Yuanyuan; Yates, Nicole L.; Sampson, Mark; Rudnicki, Erika; Juraska, Michal; deCamp, Allan C.; Edlefsen, Paul T.; Mullins, James I.; Williamson, Carolyn; Rossenkhan, Raabya; Giorgi, Elena E.; Kenny, Avi; Angier, Heather; Randhawa, April; Rojas, Michelle; Sarzotti-Kelsoe, Macella; Zhang, Lu; McDermont, Adrian; Mascola, John R.; McElrath, Juliana; Andrew, P.; Hidalgo, José A.; Clark, Jesse N.; Laher, Fatima; Orrell, Catherine; Frank, Ian; Gonzáles, Pedro; Edupuganti, Srilatha; Mgodi, Nyaradzo; Corey, Lawrence; Morris, Lynn; Montefiori, David C.; Cohen, Myron S.; Gilbert, Peter B.; Tomaras, Georgia D.

doi:10.2139/ssrn.4251188

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Antigorputz Neutralizatzaileak Gibaren Prebentzioan1

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2023

2024

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“…For HIV bnAbs to achieve broad protection against circulating HIV strains, a combination of antibodies targeting multiple epitopes will be needed. Several groups have shown that a cocktail of three complementary bnAbs, such as a combination of antibodies targeting the CD4 binding site, V3 loop and V2 loop, provide broad neutralization coverage of global viruses in vitro, which supports the rationale for clinical evaluation of such bnAb cocktails [8,9].…”

mentioning

confidence: 82%

The potential of broadly neutralizing antibodies for HIV prevention

Gelderblom,

Corey,

Barouch

2024

J Int AIDS Soc.

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mentioning

confidence: 82%

The potential of broadly neutralizing antibodies for HIV prevention

Gelderblom,

Corey,

Barouch

2024

J Int AIDS Soc.

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“…Tamalez, bi azterketetako batek ere ez zuen frogatu VRC01 antigorputzaren eraginkortasuna, ez baitzen plazeboarekin alderatuta estatistikoki esanguratsua izan. Datuen bigarren mailako analisi batek, ordea, %75eko eraginkortasuna erakutsi zuen antigorputz honekiko sentikorrak diren birus aldaerek eragindako infekzioaren murrizketan [38].…”

Section: Antigorputz Neutralizatzaileak Gibaren Prebentzioanunclassified

Espektro zabaleko antigorputzen rola GIBaren aurkako terapian eta prebentzioan

Apellániz,

Insausti

2023

EKAIA

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Terapia antirretrobiral konbinatuaren erabilera iraultza bat izan zen GIBaren infekzioaren tratamenduan eta prebentzioan. Hala ere, terapia hau ez da gai birusa organismotik erabat ezabatzeko, eta GIB infekzio kasu berrien munduko tasak mantso jaisten jarraitu du. Beraz, GIBaren prebentzio eta tratamendurako ikuspegi berriak aztertzeko beharra dago. Antigorputzak GIBaren aurkako aukera terapeutiko gisa proposatuak izan dira, epitopo biralak blokeatzeaz gain ostalariaren immunitate sistemarekin elkar ekiteko gaitasuna dutelako. Azken urteotan, GIBaren fusio proteinaren eskualde desberdinak ezagutzen dituzten espektro zabaleko zenbait antigorputz neutralizatzaile (bnAb) saio klinikoetan ebaluatuak izan dira. Lan honetan, GIBaren testuinguruan bnAb-ek eskaintzen dituzten aukerak eta beren garapen klinikoan ager daitezkeen oztopoak aztertuko dira.

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Pharmacokinetic Serum Concentrations of VRC01 Correlate with Prevention of HIV-1 Acquisition

Cited by 2 publications

References 46 publications

The potential of broadly neutralizing antibodies for HIV prevention

The potential of broadly neutralizing antibodies for HIV prevention

Espektro zabaleko antigorputzen rola GIBaren aurkako terapian eta prebentzioan

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