Pharmacokinetic Study of Methotrexate Following Intra-Articular Injection of Methotrexate Loaded Poly(L-Lactic Acid) Microspheres in Rabbits

Enhanced targeting efficiency of PLGA microspheres loaded with Lornoxicam for intra-articular administration

“…2) Colloidal substances greater than 10 nm do not gain access to the blood stream but they do reach regional lymph nodes. 3) Particles greater than 100 nm and less than 5 μm are phagocytozed by macrophages and carried to subsynovial tissue (Liang et al 2005). It is likely that Lnxc-PLGA-MS remained trapped in the joint cavity and less leakage to the joint may also be due to the microsheres size above 5 μm (∼7.47μm).…”

Cationic PLGA/Eudragit RL nanoparticles for increasing retention time in synovial cavity after intra-articular injection in knee joint

“…The various polymers that have been explored include poly(lactide), poly(lactide-co-glycolide) (PLGA), albumin, and chitosan. [8][9][10][11][12] However, NPs smaller and micro-sized particulates are prone to phagocytosis by macrophages in synovial linings. 14,15 Recently, a positively surface-charged NP composed of an uncharged polymer (ethyl cellulose or dextran derivatives) and a positively charged polymer (cationic dextran) was introduced as an alternative tool to increase the retention time in joints.…”

Formulation and Evaluation of Quercetin Polycaprolactone Microspheres for the Treatment of Rheumatoid Arthritis

“…[10][11][12][13][14][15][16] The use of microparticles composed of polycyanobutyl ester, gelatin and PLA elicited various levels of inflammation following their IA injection and these polymers might not be suitable drug carriers for IA treatment of RA. 10 Earlier in vitro studies on PLGA microspheres developed for IA applications shows complete drug release (biphasic) by 84 and 96 h for low and high molecular weight PLGA, respectively.…”