Pharmacokinetics and Bioavailability Enhancement of Natural Products

Phansalkar, Palak S.; Zhang, Zhenxian; Verenich, Svetlana; Gerk, Phillip M.

doi:10.1007/978-3-030-39855-2_4

Cited by 8 publications

(8 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The findings obtained with the extracts must be interpreted carefully if they are to be used for the benefit of patients. There are other factors such as pharmacokinetics and bioavailability [ 56 ], synergy or antagonism [ 57 , 58 ], and the adverse effects that the consumption of natural products can have that have not been developed correctly [ 59 ] and that can affect the patient, reducing their quality of life and the effect of allopathic therapy of choice.…”

Section: Discussionmentioning

confidence: 99%

Preferential Activity of Petiveria alliacea Extract on Primary Myeloid Leukemic Blast

Ballesteros-Ramírez

Aldana

Herrera

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The need for new therapeutic approaches to improve the response in acute leukemia (AL), either by directing therapy or with new therapeutic alternatives, has been a research and clinical interest topic. We evaluated whether blasts from AL patients were sensitive ex vivo to the induction chemotherapy and whether the extracts of Petiveria alliacea (Anamu SC) and Caesalpinia spinosa (P2Et) modulated the sensitivity of leukemic cells to death. Bone marrow samples were taken from 26 patients with de novo AL and 6 in relapse, and the cytotoxicity of the extracts alone or in combination with the chemotherapeutic was evaluated by XTT. Patients were classified as good (GR) and bad responders (BR) according to the ex vivo test. 70.5% of the GR patients to the ex vivo test achieved postinduction remission to induction chemotherapy with a median overall survival of 12.50 months versus 7.23 months in the two groups. Furthermore, it was found that the ex vivo response to extracts and chemotherapeutics is heterogeneous and shows an exclusive pattern between the extracts, Anamu being the more effective in inducing cell death. The combination of extracts with chemotherapeutic agents showed synergistic or antagonistic effects in the patients’ blasts. These results show that the ex vivo evaluation of the sensitivity to induction drugs using primary blasts from patients exhibits a correlation with the response to induction chemotherapy in patients. These analyses would allow establishing a system to predict response to treatment and determine ex vivo susceptibility to new therapies under development, among which is phytotherapeutics.

show abstract

Section: Discussionmentioning

confidence: 99%

Preferential Activity of Petiveria alliacea Extract on Primary Myeloid Leukemic Blast

Ballesteros-Ramírez

Aldana

Herrera

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…In preclinical and clinical investigations, curcumin, quercetin, resveratrol, and other promising natural compounds with anticancer properties have displayed problems with the dissolvement into gastrointestinal fluids, permeability across the intestinal epithelium, and “first-pass” metabolism due to the aforementioned molecular limitations which greatly reduce oral bioavailability [ 488 ]. To challenge this, chemical modifications of natural molecules can be carried out to improve them.…”

Section: Limitations Of Using Plants and Mushrooms As Medicinementioning

confidence: 99%

“…As an alternative, several approaches have been used including nanoparticle formulations, phytosomes, and the use of bioenhancers [ 488 ].…”

Section: Limitations Of Using Plants and Mushrooms As Medicinementioning

confidence: 99%

“…To increase bioavailability, self-microemulsifying drug delivery systems (SMEDDSs) are frequently formulated [ 489 ]. SMEDDS are isotropic mixtures of oils, surfactants, or (alternatively) co-surfactants and co-solvents [ 488 , 490 ]. To avoid drug precipitation, SMEDDS are supplied with hydrophilic polymers, such as polyvinylpyrrolidone and hydroxypropyl methylcellulose.…”

Section: Limitations Of Using Plants and Mushrooms As Medicinementioning

confidence: 99%

“…Another way to improve the bioavailability of natural compounds is the application of phosphatidylcholine complexes, called “phytosomes” [ 487 , 488 , 491 ]. Their effectiveness has been demonstrated regarding silibinin.…”

Section: Limitations Of Using Plants and Mushrooms As Medicinementioning

confidence: 99%

See 2 more Smart Citations

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

et al. 2022

View full text Add to dashboard Cite

Traditional herbal medicine (THM) is a “core” from which modern medicine has evolved over time. Besides this, one third of people worldwide have no access to modern medicine and rely only on traditional medicine. To date, drugs of plant origin, or their derivates (paclitaxel, vinblastine, vincristine, vinorelbine, etoposide, camptothecin, topotecan, irinotecan, and omacetaxine), are very important in the therapy of malignancies and they are included in most chemotherapeutic regimes. To date, 391,000 plant and 14,000 mushroom species exist. Their medical and biochemical capabilities have not been studied in detail. In this review, we systematized the information about plants and mushrooms, as well as their active compounds with antitumor properties. Plants and mushrooms are divided based on the regions where they are used in ethnomedicine to treat malignancies. The majority of their active compounds with antineoplastic properties and mechanisms of action are described. Furthermore, on the basis of the available information, we divided them into two priority groups for research and for their potential of use in antitumor therapy. As there are many prerequisites and some examples how THM helps and strengthens modern medicine, finally, we discuss the positive points of THM and the management required to transform and integrate THM into the modern medicine practice.

show abstract

A biocatalytic platform for the production of substituted 2-quinolones and (thio)coumarins

Sokolova,

Osipyan,

Zhang

et al. 2024

Preprint

View full text Add to dashboard Cite

Abstract2-quinolones are privileged scaffolds for drug discovery that are relatively rare in nature. Here, we characterise two promiscuous fungal polyketide synthases AthePKS and FerePKS, which we had previously found to produce quinolonesin vitro. We challenged the enzymes with several substituted anthranilic acid derivatives, revealing their ability to produce precursors of pharmaceutically relevant quinolones. We also discovered that AthePKS and FerePKS accept other 2-substituted benzoic acids, leading to the formation of coumarin and thiocoumarin scaffolds. We applied AthePKS in an artificial enzymatic cascade towards an antimicrobial 4-methoxy-1-methyl-2-quinolone and demonstrated itsin vivofeasibility by successfully expressing the pathway inEscherichia coli. Lastly, we determined the crystal structure of AthePKS, suggesting hotspots for enhancing its catalytic efficiency by enzyme engineering. Our results provide a framework for further engineering of enzymatic routes towards privileged heteroaromatic scaffolds and derivatives thereof.

show abstract

Pharmacokinetics and Bioavailability Enhancement of Natural Products

Cited by 8 publications

References 116 publications

Preferential Activity of Petiveria alliacea Extract on Primary Myeloid Leukemic Blast

Preferential Activity of Petiveria alliacea Extract on Primary Myeloid Leukemic Blast

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

A biocatalytic platform for the production of substituted 2-quinolones and (thio)coumarins

Contact Info

Product

Resources

About