Pharmacokinetics and bioavailability of ceftriaxone in brown trout (Salmo trutta fario) after intravenous and intramuscular administration

Çorum, Orhan; Er, Ayşe; Çorum, Duygu Durna; Atik, Orkun; Üney, Kamil

doi:10.1016/j.aquaculture.2018.10.026

Cited by 15 publications

(14 citation statements)

References 42 publications

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“…However, because the decrease in the activities of fish at a dose of 5 mg/kg has been reported [ 16 ], in this study, the dose of 2.5 mg/kg was selected. In addition, unlike other pharmacokinetic fish studies [ 34 , 35 , 36 ], repeated blood samples in this study were obtained. A similar design was used in pharmacokinetic studies of meloxicam and ketoprofen in fish [ 2 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Oncorhynchus mykiss) Broodstock

et al. 2021

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The aim of this study was to determine the pharmacokinetics of carprofen following intravenous (IV), intramuscular (IM) and oral routes to rainbow trout (Oncorhynchus mykiss) broodstock at temperatures of 10 ± 1.5 °C. In this study, thirty-six healthy rainbow trout broodstock (body weight, 1.45 ± 0.30 kg) were used. The plasma concentrations of carprofen were determined using high-performance liquid chromatography and pharmacokinetic parameters were calculated using non-compartmental analysis. Carprofen was measured up to 192 h for IV route and 240 h for IM, and oral routes in plasma. The elimination half-life (t1/2λz) was 30.66, 46.11, and 41.08 h for IV, IM and oral routes, respectively. Carprofen for the IV route showed the total clearance of 0.02 L/h/kg and volume of distribution at steady state of 0.60 L/kg. For IM and oral routes, the peak plasma concentration (Cmax) was 3.96 and 2.52 μg/mL with the time to reach Cmax of 2 and 4 h, respectively. The bioavailability was 121.89% for IM route and 78.66% for oral route. The favorable pharmacokinetic properties such as the good bioavailability and long t1/2λz for IM and oral route of carprofen suggest the possibility of its effective use for the treatment of various conditions in broodstock.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Oncorhynchus mykiss) Broodstock

et al. 2021

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“…The recommended dose ranges of MLX and CRP in birds are 0.1–2 mg/kg and 1–40 mg/kg, respectively (Carpenter, 2005). Although there is insufficient information about the use of TA in birds, it has been recommended for use at the dose of 2–4 mg/kg in mammals and reptiles (Corum et al, 2018; Corum, Er, et al, 2019; Tekeli et al, 2020c). Therefore, MLX, CRP, and TA were administered at 1, 10, and 2 mg/kg doses, respectively, in this study.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of meloxicam, carprofen, and tolfenamic acid after intramuscular and oral administration in Japanese quails (Coturnix coturnix japonica)

Türk

Tekeli

Çorum

et al. 2021

Vet Pharm & Therapeutics

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The aim of this study was to determine the pharmacokinetics of meloxicam (MLX), carprofen (CRP), and tolfenamic acid (TA) in Japanese quails (Coturnix coturnix japonica) following intramuscular (IM) and oral administration at doses of 1, 10, and 2 mg/kg, respectively. A total of 72 quails were randomly divided into 3 equal groups as MLX, CRP, and TA. Each group was separated into two sub‐groups that received IM and oral administration of each drug. Plasma concentrations of MLX, CRP, and TA were determined using HPLC‐UV and analyzed by non‐compartmental method. The t1/2ʎz and MRT of MLX, CRP, and TA after oral administration were similar to those after IM administration. The Vdarea/F of MLX, CRP, and TA after IM administration was 0.28, 2.05, and 0.20 L/kg. The Cl/F of MLX, CRP, and TA after IM administration was 0.12, 0.19, and 0.09 L/h/kg. MLX, CRP, and TA after oral administration showed significantly lower Cmax and longer Tmax compared with IM administration. The relative bioavailability of MLX, CRP, and TA following oral administration in quails was 76.13%, 61.46%, and 57.32%, respectively. The IM and oral route of MLX, CRP, and TA can be used for the treatment of various conditions in quails. However, further research is necessary to determine the pharmacodynamics and safety of MLX, CRP, and TA before use in quails.

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“…The plasma concentration of ceftriaxone was determined using the high-performance liquid chromatography (HPLC) -UV system (Shimadzu, Tokyo, Japan) by a previously reported method (Corum et al, 2019;Durna Corum et al, 2018). Plasma samples at -80℃ were removed from the freezer and thawed at room temperature.…”

Section: Hplc and Chromatographic Conditionsmentioning

confidence: 99%

Effect of ketoprofen and tolfenamic acid on intravenous pharmacokinetics of ceftriaxone in sheep

Gül

Çorum

et al. 2021

Vet Pharm & Therapeutics

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Ceftriaxone is a semi-synthetic third-generation cephalosporin antibiotic used in humans and animals (Reiner et al., 1980) and shows its antibacterial effect by disrupting the cell wall synthesis of bacteria.Ceftriaxone has a broad spectrum of action which covers gram-negative (Escherichia coli, Pseudomonas aeruginosa, Klebsiella spp., and Salmonella spp.) and gram-positive (Staphylococcus aureus and Streptococcus pneumoniae) bacteria (Perry & Schentag, 2001). Ceftriaxone is widely used in the veterinary field due to its broad spectrum of action, long half-life, low toxicity, and resistance to β lactamases (Cleeland & Squires, 1984;Landesman et al., 1981). Ceftriaxone is recommended for use in respiratory, urogenital, and gastrointestinal tract infections as well as in skin and soft tissue infections, septicemia, and mastitis in sheep (Durna Corum et al., 2018). The antibacterial effect of ceftriaxone is time dependent, and time when the antibiotic concentration remains above the minimum inhibitory concentration (MIC) value (T > MIC) is used in the evaluation of its efficacy. T > MIC of 40%-70% for cephalosporins is

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Pharmacokinetics and bioavailability of ceftriaxone in brown trout (Salmo trutta fario) after intravenous and intramuscular administration

Cited by 15 publications

References 42 publications

Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Oncorhynchus mykiss) Broodstock

Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Oncorhynchus mykiss) Broodstock

Pharmacokinetics of meloxicam, carprofen, and tolfenamic acid after intramuscular and oral administration in Japanese quails (Coturnix coturnix japonica)

Effect of ketoprofen and tolfenamic acid on intravenous pharmacokinetics of ceftriaxone in sheep

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