Pharmacokinetics and bioavailability of doxycycline in fasted and nonfasted broiler chickens

Laczay, Péter; Semjén, G; Lehel, József; Nagy, Gábor

doi:10.1556/004.49.2001.1.5

Cited by 26 publications

(24 citation statements)

References 7 publications

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“…Data obtained for Cl are higher than those determined in calves with mature ruminal function (1.07 ± 0.06 mL/kg/min), and in small animals, dogs (1.72 ± 0.17 mL/kg/min) and cats (1.09 ± 0.21 mL/kg/min) . Other authors determined values similar to ours in calves with immature ruminal function (2.20 ± 0.21 mL/kg/min) (Riond et al, 1989), and chickens (2.32 ± 0.12 mL/kg/min) (Laczay et al, 2001). Our values were lower than those calculated in goats with mature ruminal function (11.83 ± 0.67 mL/kg/min) (Abd El-Aty et al, 2004).…”

Section: Discussionsupporting

confidence: 83%

“…The discrepancies between values calculated for pharmacokinetic parameters may be attributed to the animal species, the drug formulation employed, the age, size or sex of the animals, to differences in fatty tissue deposits between animal species or breeds, or even to inter-individual variations (Riond et al, 1989;Jha et al, 1989). Doxycycline pharmacokinetics after PO administration were best described in this animal species by a 2-compartment open model, which is in accordance with previous studies in pigs (Baert et al, 2000), calves with immature ruminal function (van Gool et al, 1986;Meijer et al, 1993), chickens (Anadó n et al, 1994;Espigol et al, 1997;Laczay et al, 2001) and turkeys (Santos et al, 1996).…”

Section: Discussionsupporting

confidence: 83%

“…Doxycycline pharmacokinetics have been studied in several animal species (Wilson et al, 1988;Jha et al, 1989;Riond et al, 1989;Greth et al, 1993;Meijer et al, 1993;Santos et al, 1996;Baert et al, 2000;Laczay et al, 2001;Abd El-Aty et al, 2004;Davis et al, 2006) and in man (Schach von Wittenau and Chiaini, 1968;Raghuram and Krishnaswamy, 1982;Riond and Riviere, 1988), but few studies have been done in sheep (Ziv and Sulman, 1974).…”

Section: Discussionmentioning

confidence: 99%

“…The pharmacokinetics of doxycycline have been fully documented in humans (Schach von Wittenau and Chiaini, 1968;Raghuram and Krishnaswamy, 1982;Riond and Riviere, 1988) and, to a lesser extent, in veterinary species, such as dogs (Wilson et al, 1988;, cats , pigs Baert et al, 2000), horses (Davis et al, 2006), and poultry (Anadó n et al, 1994;Santos et al, 1996;Laczay et al, 2001). Limited information is available on the pharmacokinetics of doxycycline in ruminant species, where it has been studied in calves in mature and immature ruminal function (Riond et al, 1989;Meijer et al, 1993) and in goats (Jha et al, 1989;Abd El-Aty et al, 2004), but to date no studies have been conducted in sheep.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics of doxycycline in sheep after intravenous and oral administration

Castro

Sahagún

Diez

et al. 2009

The Veterinary Journal

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The pharmacokinetics of doxycycline were investigated in sheep after oral (PO) and intravenous (IV) administration. The IV data were best described using a 2-(n = 5) or 3-(n = 6) compartmental open model. Mean pharmacokinetic parameters obtained using a 2-compartmental model included a volume of distribution at steady-state (V ss ) of 1.759 ± 0.3149 L/kg, a total clearance (Cl) of 3.045 ± 0.5264 mL/ kg/min and an elimination half-life (t 1/2b ) of 7.027 ± 1.128 h. Comparative values obtained from the 3-compartmental mean values were: V ss of 1.801 ± 0.3429 L/kg, a Cl of 2.634 ± 0.6376 mL/kg/min and a t 1/2b of 12.11 ± 2.060 h. Mean residence time (MRT 0À1 ) was 11.18 ± 3.152 h. After PO administration, the data were best described by a 2-compartment open model. The pharmacokinetic parameter mean values were: maximum plasma concentration (C max ), 2.130 ± 0.950 lg/mL; time to reach C max (t max ), 3.595 ± 3.348 h, and absorption half-life (t 1=2k 01 ), 36.28 ± 14.57 h. Non-compartmental parameter values were: C max , 2.182 ± 0.9117 lg/mL; t max , 3.432 ± 3.307 h; F, 35.77 ± 10.20%, and mean absorption time (MAT 0-1 ), 25.55 ± 15.27 h. These results suggest that PO administration of doxycycline could be useful as an antimicrobial drug in sheep.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics of doxycycline in sheep after intravenous and oral administration

Castro

Sahagún

Diez

et al. 2009

The Veterinary Journal

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“…The route of drug administration plays an important role in the effectiveness of the treatment, as well as in the distribution of antibiotics to tissues (16). In the presented study, the DC penetration and concentrations in muscle, liver and kidney after oral administration were analysed.…”

Section: Discussionmentioning

confidence: 99%

LC-MS/MS analysis of doxycycline residues in chicken tissues after oral administration

Gajda¹,

Posyniak²,

Tomczyk

2014

Bulletin of the Veterinary Institute in Pulawy

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For the purpose of quantitative determination of doxycycline (DC) residues in tissues, a sensitive liquid chromatographytandem mass spectrometry (LC-MS/MS) method was developed. The method was used to determine DC residues in chicken tissues (breast and thigh muscle, liver and kidney) after oral administration with drinking water to five-weak-old broiler chickens. The DC was administered for five consecutive days at a therapeutic dose of 10 mg/kg b.w. once a day. The tissues were collected after 6 h, 24 h, 7 d, and 8 d. The method was validated and the decision limit was established for muscle -109.2 µg/kg, for liver -326.1 µg/kg, and for kidney -634.0 µg/kg. The detection limit was 2 µg/kg and the limit of quantification was 5 µg/kg. In a short period after ceasing the treatment, the detected concentrations of DC were much higher than the established maximum residue limit values. The highest residue concentrations of DC were observed in the kidney, followed by the liver and muscle. The lowest concentration of DC was determined in tight muscle.

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Disposition kinetics of doxycycline in chickens naturally infected with Mycoplasma gallisepticum

Ismail¹,

El-Kattan²

2004

British Poultry Science

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1. The pharmacokinetic properties of doxycycline were determined in healthy chickens and chickens naturally infected with Mycoplasma gallisepticum after a single intravenous (i.v.) and oral administration of the drug at 20 mg/kg body weight. Tissue residues of the tested drug after an oral dose of 20 mg/kg given twice daily for 5 consecutive days were also estimated in diseased chickens. 2. The plasma concentrations of doxycycline following single i.v. and oral administration were higher in healthy chickens than in diseased ones. Following i.v. injection, the elimination half-life (t1/2beta), distribution half-life and mean residence time (MRT) were longer in healthy chickens than in diseased birds. The values of total body clearance (ClB) and volume of distribution (Vdss) were larger in healthy chickens than in diseased birds. 3. After single oral administration, the absorption half-life (tl/2ab) and the elimination half-life were longer in normal birds than in diseased ones. The maximum plasma concentration of the drug was higher in normal chickens than in diseased ones. 4. Following repeated oral administration, the concentration of doxycycline in all tissues except muscle was higher than the corresponding concentrations in plasma. Concentrations of doxycycline in different tissues were in the following order: kidney > liver > lung > muscle. The drug was detected in liver and kidney in substantial concentrations on d 5 post administration of the last dose whereas, on d 7, its concentration in all tissues was below the lower limit of the sensitivity of the assay method used. Because of the low sensitivity of the microbiological assay method used in this study, a safe withdrawal time for doxycycline in diseased birds could not be estimated for the meanwhile.

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Pharmacokinetics and bioavailability of doxycycline in fasted and nonfasted broiler chickens

Cited by 26 publications

References 7 publications

Pharmacokinetics of doxycycline in sheep after intravenous and oral administration

Pharmacokinetics of doxycycline in sheep after intravenous and oral administration

LC-MS/MS analysis of doxycycline residues in chicken tissues after oral administration

Disposition kinetics of doxycycline in chickens naturally infected with Mycoplasma gallisepticum

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