Pharmacokinetics and bioavailability of oxytetracycline in gilthead sea bream (Sparus aurata) after a single dose

Rigos, George; Nengas, Ioannis; Tyrpenou, A. E.; Alexis, M.N.; Troisi, G. M.

doi:10.1016/s0044-8486(03)00071-1

Cited by 65 publications

(40 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…noatunensis strains tested in this investigation was found to be 64 µg ml −1 . The pharmacokinetic profile for this drug has been studied in a number of marine fish species but not in cod (Elema et al 1996, Rigos et al 2003, 2004a,b, Wang et al 2004. The plasma C max for oxytetracycline varies considerably in marine fish, and the absorption of oxytetracycline from the intestine is, due to complexation with di-and tri-valent cations, normally rather low.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antimicrobial susceptibility of Francisella noatunensis subsp. noatunensis strains isolated from Atlantic cod Gadus morhua in Norway

Isachsen

Vågnes²,

Jakobsen³

et al. 2012

Dis. Aquat. Org.

View full text Add to dashboard Cite

A total of 30 isolates of Francisella noatunensis subsp. noatunensis isolated from Atlantic cod Gadus morhua L. were tested for susceptibility, in the form of minimal inhibitory concentration (MIC) values, against the following antibacterial agents: flumequine, oxolinic acid, ciprofloxacin, florfenicol, oxytetracycline, erythromycin, streptomycin sulphate, trimetoprim/ sulphadiazine and rifampin. All the isolates had a low susceptibility to oxytetracycline, trimetoprim/sulphadiazine (Tribrissen ® ), erythromycin, ciprofloxacin and streptomycin with MIC values of 64, 64 to 128, 16, 8 and 32 to 128 µg ml Dis Aquat Org 98: [57][58][59][60][61][62] 2012 markedly more active against oxolinic-acid-resistant isolates of Aeromonas salmonicida (Lewin & Hastings 1990). F. noatunensis subsp. noatunensis is a slowgrowing bacterium, and rifampin, erythromycin and streptomycin sulphate are all antibacterial agents that are used in human medicine in the treatment of Mycobacterium tuberculosis, another slow-growing bacterium. Erythromycin is also occasionally used against bacterial kidney disease (BKD) in salmonids.The aim of the present study was to test the susceptibility, in the form of MIC values, to a number of isolates of Francisella noatunensis subsp. noatunensis against the selected group of antibacterial agents. MATERIALS AND METHODS Bacterial strainsA total of 30 isolates of Francisella noatunensis subsp. noatunensis from Atlantic cod Gadus morhua L. were analysed. Of these, 28 isolates were provided by the Norwegian Veterinary Institute (Norway) and 2 isolates, GM2212/LMG 24256 (Nylund et al. 2006, Ottem et al. 2007) and EK-4b, were provided by the Institute of Marine Research (Norway). All isolates originate from farmed cod, except EK-4b, which was isolated from a wild cod. The strains were previously identified as F. noatunensis subsp. noatunensis using the methods described by Ottem et al. (2008). ChemicalsFlumequine, oxolinic acid, oxytetracycline, florfenicol, Tribrissen (trimethoprim/sulfadiazine), erythromycin, ciprofloxacin, streptomycin sulphate and rifampin were all obtained from Norwegian Medical Depot (Bergen, Norway). Stock solutions of antibacterial agents were prepared at a concentration of 1.0 mg ml −1 in methanol (florfenicol, Tribrissen, rifampin), in water (oxytetracycline, erythromycin, streptomycin sulphate), 0.03 M NaOH (flumequine, oxolic acid) and 0.03 M NaOH/methanol (1:1) (ciprofloxacin). MIC determinationIn order to meet the demands of Francisella noatunensis subsp. noatunensis for specific growth factors, the method of choice in the present work was a modified agar dilution test for the determinations of MIC values (Alderman & Smith 2001). Briefly, F. noatunensis subsp. noatunensis isolates were grown on modified Mueller-Hinton agar (MMHA) supplemented with 3% foetal bovine serum (FBS) (PAA Laboratories), 0.8% glucose (Merck), 0.4% L-cystein (Sigma) and 4% Yeastolate Ultrafiltrate (Gibco) and containing 2-fold dilutions of the antibacterial agents tested. All supplements and a...

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Antimicrobial susceptibility of Francisella noatunensis subsp. noatunensis strains isolated from Atlantic cod Gadus morhua in Norway

Isachsen

Vågnes²,

Jakobsen³

et al. 2012

Dis. Aquat. Org.

View full text Add to dashboard Cite

show abstract

“…In O. mykiss, t ½ α, t ½ β, V dss , and MRT (mean residence time) values for oxolinc acid were less in sea than fresh water, although the Cl T was longer (Table 2). Rigos et al (2003) postulated that salinity may lead to low F of oxytetracyline in marine fish due to the formation of complexes between tetracyclines and cations found in water and feed, resulting in a possible reduction of absorption across membranes. Some sampling techniques, e.g., the dorsal aorta cannulation technique, might have an influence on pharmacokinetic parameters.…”

Section: Factors That Have An Influence On Pharmacokineticsmentioning

confidence: 99%

“…Characterization of the pharmacokinetics of a chemical in fish is useful for estimation of the bioconcentration factor and half-life (Haug and Hals, 2000). Compartmental models that assume the fish to behave as one or more well-stirred compartments are the most common type of pharmacokinetic model used (Rigos et al, 2003;Zhang and Li, 2007). On the other hand, little is known about integral analysis of pharmacokinetics in aquatic organisms and specific relations between the pharmacokinetic parameters and influence factors.…”

Section: Introductionmentioning

confidence: 99%

Residual pharmaceutically active compounds (PhACs) in aquatic environment - status, toxicity and kinetics: a review

Li¹,

Randák²

2009

Vet. Med.

View full text Add to dashboard Cite

Awareness of residual pharmaceutically active compounds (PhACs) in aquatic ecosystems is growing as research into these pollutants increases and analytical detection techniques improve. For most pharmaceuticals analyzed, the effects on aquatic organisms have usually been investigated by toxic assays in the laboratory. However, little is known about integral analysis of pharmacokinetics in aquatic organisms and specific relations between pharmacokinetic parameters and influence factors. Moreover, the influence of the organisms involved and numerous other external factors complicates development of standard tests for environmental evaluation. Current knowledge about residual pharmaceuticals in the aquatic environment, including status, toxic effects, and pharmacokinetics in aquatic organisms, are reviewed. Based on the above, we identify major gaps in the current knowledge and some directions for future research, such as improvement of techniques to remove residual pharmaceuticals from wastewater, and the establishment of standard pharmaceutical modes of action.

show abstract

“…The residue of OTC and TC has been investigated in several farmed fish species including flounder, following intramuscular or oral administration [10][11][12][18][19][20]. However, there is scarcely the research for the residue of tetracycline antibiotics in tissue of farmed fishes after dipping administration.…”

mentioning

confidence: 99%

Application of a Solid-Phase Fluorescence Immunoassay to Determine Oxytetracycline and Tetracycline Residues in Tissue of Olive Flounder (<i>Paralichthys olivaceus</i>)

Kim

Chung

et al. 2006

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. Parallux TM , a solid-phase fluorescence immunoassay (SPFIA) developed for antibotics residue detection in milk, was applied for analysis of fish tissue. The recommended therapeutic doses of oxytetracycline (OTC, 100 g/ton water, withdrawal period 30 days) and tetracycline (TC, 150 g/ton water, withdrawal period 30 days) were treated to a group of 35 olive flounders (Paralichthys olivaceus) using dipping administration. Muscle was sampled before and after drug treatment 1st, 2nd, 3rd, 5th, 7th, and 14th day. The concentration of oxytetracycline in muscle, determined by SPFIA, was compared with that of internal standard (100 ppb as oxytetracycline). The S/C ratio of sample inhibition value to cutoff inhibition value was employed as an index to determine the muscle residue in olive flounder. To investigate the recovery rate, and standard solutions were added to muscle samples to give final concentrations in muscle of 0.1 and 0.5 µg/ml. The recovery rates of all spiked samples were >89% of the spiked value. OTC and TC were detected in muscle of fishes treated until the 3rd day of withdrawal period. The present study showed that the SPFIA can be easily adopted in predicting tissue residues for OTC and TC in farmed fishes. KEY WORDS: flounder, solid-phase fluorescence immunoassay, tetracycline antibiotics.

show abstract

Pharmacokinetics and bioavailability of oxytetracycline in gilthead sea bream (Sparus aurata) after a single dose

Cited by 65 publications

References 16 publications

Antimicrobial susceptibility of Francisella noatunensis subsp. noatunensis strains isolated from Atlantic cod Gadus morhua in Norway

Antimicrobial susceptibility of Francisella noatunensis subsp. noatunensis strains isolated from Atlantic cod Gadus morhua in Norway

Residual pharmaceutically active compounds (PhACs) in aquatic environment - status, toxicity and kinetics: a review

Application of a Solid-Phase Fluorescence Immunoassay to Determine Oxytetracycline and Tetracycline Residues in Tissue of Olive Flounder (<i>Paralichthys olivaceus</i>)

Contact Info

Product

Resources

About