Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats

Zhang, Shuang‐Qing; Zhang, Yan; Ning, Peng; Zhang, Haibo; Yao, Juan; Li, Zhihong; Liu, Liegang

doi:10.1155/2014/217142

Cited by 13 publications

(12 citation statements)

References 14 publications

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“…The time-concentration profiles of both complexes are in agreement with the findings of a previous study [ 32 ]. The differences in the profiles of Zn II complexes 1 and 2 observed in this study are probably due to their structural differences regarding the composition of their ligands.…”

Section: Resultssupporting

confidence: 91%

Novel Zinc(II) Complexes [Zn(atc-Et)2] and [Zn(atc-Ph)2]: In Vitro and in Vivo Antiproliferative Studies

Lopes

Oliveira²,

Silva

et al. 2016

IJMS

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Cisplatin and its derivatives are the main metallodrugs used in cancer therapy. However, low selectivity, toxicity and drug resistance are associated with their use. The zinc(II) (ZnII) thiosemicarbazone complexes [Zn(atc-Et)2] (1) and [Zn(atc-Ph)2] (2) (atc-R: monovalent anion of 2-acetylpyridine N4-R-thiosemicarbazone) were synthesized and fully characterized in the solid state and in solution via elemental analysis, Fourier transform infrared (FTIR), ultraviolet-visible (UV-Vis) and proton nuclear magnetic resonance (1H NMR) spectroscopy, conductometry and single-crystal X-ray diffraction. The cytotoxicity of these complexes was evaluated in the HepG2, HeLa, MDA-MB-231, K-562, DU 145 and MRC-5 cancer cell lines. The strongest antiproliferative results were observed in MDA-MB-231 and HepG2 cells, in which these complexes displayed significant selective toxicity (3.1 and 3.6, respectively) compared with their effects on normal MRC-5 cells. In vivo studies were performed using an alternative model (Artemia salina L.) to assure the safety of these complexes, and the results were confirmed using a conventional model (BALB/c mice). Finally, tests of oral bioavailability showed maximum plasma concentrations of 3029.50 µg/L and 1191.95 µg/L for complexes 1 and 2, respectively. According to all obtained results, both compounds could be considered as prospective antiproliferative agents that warrant further research.

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Section: Resultssupporting

confidence: 91%

Novel Zinc(II) Complexes [Zn(atc-Et)2] and [Zn(atc-Ph)2]: In Vitro and in Vivo Antiproliferative Studies

Lopes

Oliveira²,

Silva

et al. 2016

IJMS

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“…[12] The increased bioavailability of the trace elements using yeast or bacteria as a vehicle compared with the inorganic forms of the trace element have been reported in many studies. [11,[14][15][16] The use of microorganisms for delivering of these nutrients is of relevance for the production of functional foods with these micronutrients.…”

Section: Introductionmentioning

confidence: 99%

Application of food-grade microorganisms for addressing deterioration associated with fortification of food with trace metals

Kanamarlapudi

Muddada

2019

International Journal of Food Properties

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Malnutrition caused by iron deficiency can be overcome by fortification of food with iron. For the first time, metal (iron) bound/uptake food-grade microorganisms were used as fortificants in order to prevent deteriorative changes and to preserve the organoleptic acceptability of the fortified food. In the present study, biosorption capacity of Bacillus subtilis and uptake capacity of Saccharomyces cerevisiae for iron ions was determined by Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) and found to be 7.1 ± 0.2 and 3.2 ± 0.2 mg per gram of the biosorbent respectively. Chocolate was fortified with various concentrations of biosorbed/uptaken iron, inorganic (free) iron and free biomass. Appearance, chemical and microbiological changes associated with fortification was monitored for 28 and 30 days of storage at 30°C respectively. Chocolate fortified with free (inorganic) iron showed significant increase in thiobarbituric acid (TBA) values when compared with the biosorbed/uptaken iron-fortified or free biomass-fortified chocolate samples. Black discoloration was observed in free iron-fortified samples when compared with samples fortified with metal enriched biomass or free biomass.

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“…Ortman and Pehrson [8] reported that organic Se from Se-enriched yeast is an ideal supplement because animals retain and absorb it more efficient than the inorganic form of Se. Zn-enriched yeast is naturally integrated by the growing yeast into its own structure to improve the bioavailability of Zn and reduce the sides effects of Zn [9] . In mammals, chromium (Cr) has been recognized to be a biologically essential trace element.…”

Section: Introductionmentioning

confidence: 99%

Tahıl Samanının in vitro Fermantasyon Özelliklerini Geliştirmede Se, Cr ve Zn İle Zenginleştirilmiş Maya Kültürünün Değerlendirilmesi

Chen¹,

Li²,

Ren³

et al. 2018

Kafkas Univ Vet Fak Derg

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The object of this study was to evaluate the effect of different sources and supplementation levels of yeast culture on in vitro fermentation characteristics of goats. The present study was performed in a 3×4 factorial design to examine the impacts of inclusion of three kinds of yeast culture (Se-enriched, Cr-enriched, Zn-enriched yeast culture) at four dose (0, 0.1%, 0.25%, 0.40% and 0.55%) on the in vitro fermentation characteristics of cereal straw. For maize stover, the results shown that the average values of in vitro gas production, DM and NDF disappearance, pH and the ratio of acetate to propionate were increased (P<0.05), while the concentration of ammonia nitrogen (NH3-N) and butyrate were decreased (P<0.05) by the supplementation of Se-enriched yeast culture (YC-Se) compared with that of Cr-enriched yeast culture (YC-Cr) and Zn-enriched yeast culture (YC-Zn). For rice straw, the in vitro gas production, DM disappearance and pH were increased (P<0.05), and the concentration of ammonia nitrogen was decreased by the supplementation of YC-Se, while the concentration of acetate, propionate, butyrate and total VFA (TVFA) were increased (P<0.05) by the supplementation of YC-Zn. The current results indicate that YC-Se is more preferred as yeast culture supplements, and its optimal dose should be 0.25% substrates for maize stover and 0.10% substrates for rice straw in vitro. The present positive in vitro results should be tested using in vivo experiments in future.

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Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats

Cited by 13 publications

References 14 publications

Novel Zinc(II) Complexes [Zn(atc-Et)2] and [Zn(atc-Ph)2]: In Vitro and in Vivo Antiproliferative Studies

Novel Zinc(II) Complexes [Zn(atc-Et)2] and [Zn(atc-Ph)2]: In Vitro and in Vivo Antiproliferative Studies

Application of food-grade microorganisms for addressing deterioration associated with fortification of food with trace metals

Tahıl Samanının in vitro Fermantasyon Özelliklerini Geliştirmede Se, Cr ve Zn İle Zenginleştirilmiş Maya Kültürünün Değerlendirilmesi

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