Pharmacokinetics and Biological Activity of the New Intermediate-Acting Insulin L-SNC<sup>1</sup>)

Schulz, B; Menzel, R; Ratzmann, K P; Heinke, P.

doi:10.1055/s-0029-1210702

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…rA After injection of human insulin, basal C-peptide concentrations decreased significantly in negative correlation to IRI. This indicates an inhibition of insulin secretion by exogenous insulin, consistent with previous studies (Ratzmann and Schulz, 1985;Schulz et al, 1987).…”

Section: Discussionsupporting

confidence: 92%

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Semisynthetic Human Insulin: Pharmacokinetics and Biological Potency in Healthy Subjects in Comparison with Highly Purified Porcine Insulin

Schulz

Stöwhas²,

Becker³

et al. 2009

Exp Clin Endocrinol Diabetes

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Pharmacokinetics and the biological activity of a new semisynthetic human insulin (VEB Berlin-Chemie) were investigated in 5 healthy men. Following an overnight fast, 0.2 IU per kg body weight of human and pork insulins (SNC insulin; VEB Berlin-Chemie) were injected subcutaneously into thigh of each individual at a time interval of 8 days. To assess biological potency of both insulins all subjects were twice connected to the BIOSTATOR. A very similar pattern of serum insulin levels (IRI) was observed following subcutaneous injection of human and pork insulin, marked by a sharp initial increase and maximum values reached after 2.5 hours. 8 hours after the insulin administration the original fasting concentrations were nearly attained. According to C-peptide levels, both insulins inhibited endogenous insulin secretion. Evaluation of insulin action was determined by euglycemic clamp technique, provided by the BIOSTATOR, whose function was transformed into a glucose-controlled dextrose infusion system. The amount of glucose delivered by the system in order to keep the blood glucose steady state concentrations at the fasting level was utilized as the measure of biological activity of the injected insulin on glucose metabolism. Maximum values of glucose infusion were achieved between 3 and 4 hr after injection of human and pork insulins. At the end of the study (8 hr) the glucose administration did not return to its initial rate. After administration of both the human and porcine insulins, a marked but similar decrease of FFA concentrations was observed. This indicated a clear-cut inhibition of lipolysis.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionsupporting

confidence: 92%

“…To evaluate the profile of biological activity of human insulin we used the euglycemic clamp technique provided by the BIOSTATOR (Schulz et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

Semisynthetic Human Insulin: Pharmacokinetics and Biological Potency in Healthy Subjects in Comparison with Highly Purified Porcine Insulin

Schulz

Stöwhas²,

Becker³

et al. 2009

Exp Clin Endocrinol Diabetes

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“…(suspension of pork insulin purified by chromatography; 30% amorphous and 70% crystalline; Berlin-Chemie, GDR) was introduced into the practice. Its pharmacokinetics and biological activity with a duration of more than 16 hours were found to be appropriate to cover the night and to prevent dawn phenomenon in insulin-dependent diabetics (Schulz et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Mixing Regular- and Intermediate-Acting Insulins on Their Absorption and Biological Activity¹)

Schulz

Menzel²,

Besch³

2009

Exp Clin Endocrinol Diabetes

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Many insulin-dependent diabetics are now treated with different regimens of short- and intermediate-acting insulins. The new L-insulin S.N.C. (Berlin-Chemie) is thought to be appropriate for a combination with regular insulin. We investigated whether or not absorption kinetics and biological activity changes when L-insulin S.N.C. is mixed with regular insulin S.N.C. Eight non-obese healthy male subjects were connected to the BIOSTATOR. After an overnight fast 0.1 U of insulin S.N.C. and 0.3 U per kg b.w. of L-insulin S.N.C. or Monotard MC insulin (NOVO) were administered either in a mixture or separately. Injecting L-insulin S.N.C. and insulin S.N.C. in a mixture there was some, but not a statistically significant, delay in absorption of insulin. A mixture of insulin S.N.C. and Monotard provoked a marked delay of absorption during the first two hours. To examine biological activity we used the BIOSTATOR (glucose controlled dextrose infusion system). Glucose infusion rate necessary to keep blood glucose steady state concentration was taken as a measure of insulin action. Whereas mixing of insulin S.N.C. and L-insulin S.N.C. only slightly changed the profile of biological activity, a mixture of insulin S.N.C. and Monotard has a clear-cut higher potency during the late phase when compared with separately injected insulins. Therefore, insulin S.N.C. and Monotard should not be mixed. A mixture of insulin S.N.C. and L-insulin S.N.C. is also not recommended but can be done in exceptional cases.

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Pharmacokinetics and Biological Activity of the New Intermediate-Acting Insulin L-SNC¹)

Cited by 2 publications

References 13 publications

Semisynthetic Human Insulin: Pharmacokinetics and Biological Potency in Healthy Subjects in Comparison with Highly Purified Porcine Insulin

Semisynthetic Human Insulin: Pharmacokinetics and Biological Potency in Healthy Subjects in Comparison with Highly Purified Porcine Insulin

The Effect of Mixing Regular- and Intermediate-Acting Insulins on Their Absorption and Biological Activity¹)

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Pharmacokinetics and Biological Activity of the New Intermediate-Acting Insulin L-SNC1)

Cited by 2 publications

References 13 publications

Semisynthetic Human Insulin: Pharmacokinetics and Biological Potency in Healthy Subjects in Comparison with Highly Purified Porcine Insulin

Semisynthetic Human Insulin: Pharmacokinetics and Biological Potency in Healthy Subjects in Comparison with Highly Purified Porcine Insulin

The Effect of Mixing Regular- and Intermediate-Acting Insulins on Their Absorption and Biological Activity1)

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Pharmacokinetics and Biological Activity of the New Intermediate-Acting Insulin L-SNC¹)

The Effect of Mixing Regular- and Intermediate-Acting Insulins on Their Absorption and Biological Activity¹)