1993
DOI: 10.1002/ijc.2910540614
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Pharmacokinetics and biological responses after treatment of the rat R‐1 rhabdomyosarcoma with methotrexate

Abstract: Time relationships of drug concentrations in tissue of a transplantable rat rhabdomyosarcoma and of tumour responses up to 120 hr after treatment with methotrexate (MTX) were analysed and compared. MTX was shown to be retained within the tumour in a substantial concentration for several days, although no evidence of MTX polyglutamation was obtained. The response data confirm that MTX is active in the tumour for up to at least 3 days after injection. Within the first day after MTX treatment the nucleotide pools… Show more

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