Pharmacokinetics and Drug Interactions of Herbal Medicines: A Missing Critical Step in the Phytomedicine/Drug Development Process

Obodozie, Obiageri O.

doi:10.5772/33699

Cited by 7 publications

(6 citation statements)

References 98 publications

(73 reference statements)

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“…Na gravidez, lactação e amamentação algumas plantas são contraindicadas para uso interno (oral), como, arnica, calêndula, copaíba, capim-limão, cavalinha, camomila, guaco, romã, alecrim, sálvia a partir de investigações realizadas in-vivo ou ainda pela ausência de estudos sobre toxicologia reprodutiva conclusivos [31,35] . O cuidado na prescrição, de plantas medicinais e fitoterápicos, deve extender-se aos demais indivíduos, em especial aqueles que fazem uso rotineiro de fármacos sintéticos ou apresentam alguma co-morbidade sistêmica pelo risco de ocorrência de interações medicamentosas, área ainda pouco entendida [49][50][51][52] .…”

Section: Interações Medicamentosas E Contraindicaçõesunclassified

“…Dessa forma, a fim de considerar o maior número de aspectos relevantes, para que os ensaios clínicos com fitoterápicos sejam bem executados, alguns requisitos devem estar presentes: (1) ser conduzidos com extratos padronizados, ou seja, com caracterização qualitativa e quantitativa dos constituintes químicos; (2) ter diagnóstico preciso dos pacientes incluídos no ensaio; (3) adequação da população de estudo para que os resultados permitam extrapolação para a população total; (4) randomização e cegamento para minimizar vieses e a superestimativa dos resultados [52] .…”

Section: Interações Medicamentosas E Contraindicaçõesunclassified

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Fitoterapia na prática clínica odontológica: produtos de origem vegetal e fitoterápicos

Monteiro

Fraga

2021

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A Fitoterapia é uma das práticas que fazem parte da Política Nacional de Práticas Integrativas e Complementares (PNPIC), do Ministério da Saúde do Brasil, fazendo parte da Atenção Básica do Sistema Único de Saúde (SUS), inclusive para a Odontologia. Assim, o objetivo geral do presente trabalho foi sistematizar os principais produtos de origem vegetal com potencial terapêutico para a Odontologia, através da revisão integrativa de documentos oficiais (monografias de farmacopeias) e artigos disponíveis nas bases de dados indexadas. No total foram relacionadas 24 espécies vegetais em 35 preparações e cinco especialidades farmacêuticas, distribuídas pelas classes terapêuticas - anestésico tópico, ansiolítico, antifúngico, anti-inflamatório, antisséptico bucal, antiviral, hemostático, hidratante/protetor epidérmico e outros. Apesar das dificuldades da incorporação da Fitoterapia na prática clínica, a pesquisa, desenvolvimento e inovação, ampliam as possibilidades terapêuticas para a população, com a vantagem de apresentar baixo custo no processo de promoção da saúde, condizente com o momento atual da humanização da relação profissional/paciente, tanto nas políticas públicas quanto nas ações sociais.

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Section: Interações Medicamentosas E Contraindicaçõesunclassified

Fitoterapia na prática clínica odontológica: produtos de origem vegetal e fitoterápicos

Monteiro

Fraga

2021

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“…The progressive move from the long-established mono-drug therapy to the newer idea of multidrug therapy is considerably promoting phytotherapy [ 4 ]. Indeed, phytotherapy plays a key “innate” role, given that it relies on the effectiveness of herbs or plants, which contain complex mixtures of bioactive compounds that complement one another to achieve greater efficacy.…”

Section: Introductionmentioning

confidence: 99%

“…When a pharmacokinetic interaction occurs, the phytotherapeutic modifies the absorption, distribution, metabolism, protein binding, or excretion of a drug, thereby altering the levels of the drug or its metabolites. On the other hand, pharmacodynamic interactions can take place when a plant-derived substance produces additive, synergistic, or antagonist activity with respect to the conventional drug [ 4 ]. Antagonism is observed when the effects of two compounds are lower than the sum of each one, while quite the reverse is observed in additive interactions given that, in this case, the effects of the two compounds are the sum of each one [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effects of Caffeine in Combination with Conventional Drugs: Perspectives of a Drug That Never Ages

et al. 2023

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Plants have been known since ancient times for their healing properties, being used as preparations against human diseases of different etiologies. More recently, natural products have been studied and characterized, isolating the phytochemicals responsible for their bioactivity. Most certainly, there are currently numerous active compounds extracted from plants and used as drugs, dietary supplements, or sources of bioactive molecules that are useful in modern drug discovery. Furthermore, phytotherapeutics can modulate the clinical effects of co-administered conventional drugs. In the last few decades, the interest has increased even more in studying the positive synergistic effects between plant-derived bioactives and conventional drugs. Indeed, synergism is a process where multiple compounds act together to exert a merged effect that is greater than that of each of them summed together. The synergistic effects between phytotherapeutics and conventional drugs have been described in different therapeutic areas, and many drugs are based on synergistic interactions with plant derivatives. Among them, caffeine has shown positive synergistic effects with different conventional drugs. Indeed, in addition to their multiple pharmacological activities, a growing body of evidence highlights the synergistic effects of caffeine with different conventional drugs in various therapeutic fields. This review aims to provide an overview of the synergistic therapeutic effects of caffeine and conventional drugs, summarizing the progress reported to date.

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“…Plant-based medicines have a significant part of the pharmaceutical market in the whole world. It is a well-known fact that plant extracts show some advantages over synthetic pharmaceutics due to the synergism of plant constituents [1]. However, the standartisation of herbal medicines is usually determined by macroscopic and microscopic examination with the following assay of the main biomarker [2,3].…”

Section: Introductionmentioning

confidence: 99%

Comparison of components profile in herbal raw material, extract and pharmaceuticals of Hedera Helix

Безрук

Georgiyants

Ivanauskas

2020

ScienceRise: Pharmaceutical Science

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The aim. To investigate both the profile of components and possible difference among herbal raw materials, semi-products and pharmaceuticals of Hedera helix for determination of main standartisation markers. Materials and methods. Investigation of components profile has been performed using the Shimadzu Nexera X2 chromatographic system coupled with a diode-area detector. The ACE C 18 column (250 mm×4.6 mm with particle size 5 m) was used for the separation of components. 0.1 % acetic acid and acetonitrile were used as mobile phase A and B, respectively. Studies have been performed on the leaves, dry extract and capsules of H. helix. Results. The determined profile had no significant variation among samples. It has been presented by 19 various components, such as phenolic acids, flavonoids and triterpene saponins. However, kaempferol, nicotiflorin and t-cinnamic acid were not found in the leaf raw material. Hederacoside C might be highlighted as the main marker of raw materials and products of H. helix due to its significant amount in comparison to other components. Its amount was in the range of 64,80 % up to 71,46 % of the total content of components. Moreover, according to some pharmacological studies, hederacoside C is responsible for pharmaceutical usage of H. helix pharmaceutics. Nevertheless, it is not recommended to standardize the plant-based medicines by one marker, since the pharmaceutical activity of such dosage forms is defined by synergism action of all constituents. Except for hederacoside C significant amounts in comparison to other components were found for chlorogenic acid and 4,5dicaffeoylquinic acid about 5 % and 3 % respectively. Though the latter was found in small concentrations in leaves (0,058 %). This sample had a much higher amount of 3,5-dicaffeoylquinic acid, but in the case of extract and capsules, its content was lower 1,55 % and 0,66 % respectively. Thus, chlorogenic acid has been chosen as a second marker due to its high concentration in all samples and some pharmaceutical activities, such as antioxidant and anti-inflammatory effects. Conclusions. It was found, that standartisation of H. helix products is preferably to perform with determination both hederacoside C and chlorogenic acid. These components were dominant among all components; besides they possess a wide range of pharmaceutical effects. Hence, quantification of hederacoside C and chlorogenic acid is necessary to ensure the high quality of H. helix pharmaceuticals.

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Pharmacokinetics and Drug Interactions of Herbal Medicines: A Missing Critical Step in the Phytomedicine/Drug Development Process

Cited by 7 publications

References 98 publications

Fitoterapia na prática clínica odontológica: produtos de origem vegetal e fitoterápicos

Fitoterapia na prática clínica odontológica: produtos de origem vegetal e fitoterápicos

Synergistic Effects of Caffeine in Combination with Conventional Drugs: Perspectives of a Drug That Never Ages

Comparison of components profile in herbal raw material, extract and pharmaceuticals of Hedera Helix

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