Pharmacokinetics and effects on clinical and physiological parameters following a single bolus dose of propofol in common marmosets (Callithrix jacchus)

Abstract

The objectives of this study were (a) to establish a population pharmacokinetic model and (b) to investigate the clinical and physiological effects of a single bolus dose of propofol in common marmosets. In Study 1, pharmacokinetic analysis was performed in six marmosets under sevoflurane anaesthesia. 8 mg/kg of propofol was administrated at a rate of 4 mg kg−1 min−1. Blood samples were collected 2, 5, 15, 30, 60, 90, 120 or 180 min after starting propofol administration. Plasma concentration was measured, and population pharmacokinetic modelling was performed. A two‐compartment model was selected as the final model. The population pharmacokinetic parameters were as follows: V1 = 1.14 L, V2 = 77.6 L, CL1 = 0.00182 L/min, CL2 = 0.0461 L/min. In Study 2, clinical and physiological parameters were assessed and recorded every 2 min after 12 mg/kg of propofol was administrated at a rate of 4 mg kg−1 min−1. Immobilization was sustained for 5 min following propofol administration without apparent bradycardia. While combination of propofol and sevoflurane caused apnoea in Study 1, apnoea was not observed following single administration of propofol in Study 2. These data provide bases for further investigation on intravenous anaesthesia using propofol in common marmosets.

Propofol infusions using a human target controlled infusion (TCI) pump in chimpanzees (Pan troglodytes)

“…The difference between measured and predicted Cps deviated more in the early phase compared to later phases. This observation is consistent with previous reports that the measured propofol Cps can differ greatly from predicted Cps during the first few minutes of administration in humans 22 and also in Japanese macaques 23,24 and common marmosets 25 . This is probably because these models make the incorrect assumption of immediate mixing of administered drugs within the central compartment.…”

Effect of sedatives or anesthetics on the measurement of resting brain function in common marmosets

“…(This condition is equivalent to sedation score 3 for both response to sound stimulation and to direct stimulation in the primate sedation score reported by Miyabe et al. (2001) and Muta et al. (2021) .” All doses except for IsoDex were decided based on a preliminary study.…”

“…Immediately after bolus administration, the predicted plasma concentration of Propo was titrated to 7–9 μg/mL for intratracheal intubation with continuous infusion. The administration dose and protocol were calculated beforehand using a pharmacokinetic parameter reported by Muta et al. (2021) and pharmacokinetic analysis software, NONMEM ver.…”

Effects of body mass index on propofol-induced cardiovascular depression in the Pakistani population

“…1 Easy control of the depth of anesthesia, rapid recovery of consciousness, and less postoperative nausea and vomiting are the characteristics that make propofol a standard agent for induction of anesthesia. 2,3 Common adverse effects of propofol include hypotension, bradycardia, respiratory depression, myoclonus, and pain at the injection site. 4 The most common among these adverse effects is propofolinduced hypotension; this decrease in blood pressure is due to the inhibition of myocardial contractility, a decrease in peripheral resistance, and sympathetic inhibition.…”

“… 1 Easy control of the depth of anesthesia, rapid recovery of consciousness, and less postoperative nausea and vomiting are the characteristics that make propofol a standard agent for induction of anesthesia. 2 , 3 …”