Pharmacokinetics and Efficacy of Long-Term Epidural Ropivacaine Infusion for Postoperative Analgesia

Pharmacokinetic profiles of epidural bupivacaine and ropivacaine following single‐shot and continuous epidural use in young infants

“…(2-3 days). These results are consistent with previous studies (12)(13)(14)(15)(16). The highest unbound concentration was 0.12 mgAEl )1 for bupivacaine and 0.13 mgAEl )1 for ropivacaine, well below the neurotoxic arterial values reported by Knudsen et al (17) in healthy adult volunteers (0.3 mgAEl )1 for bupivacaine and 0.6 mgAEl )1 for ropivacaine).…”

Rationale and Technique for Single and Multiple Drug Combinations in Long-term Intrathecal Infusions

“…51 b) Ropivacaine-The affinity of ropivacaine for Adelta and C fibers makes this amide local anesthetic an excellent choice for providing analgesia without marked motor block. 52,53 This makes it very desirable when combination therapy is indicated. The theoretically better cardiotoxicity profile would make it a preferred choice over bupivacaine.…”

“…The theoretically better cardiotoxicity profile would make it a preferred choice over bupivacaine. 52,54 One more advantage is the lower lipid solubility as compared to bupivacaine, which makes the concentration in the CSF higher and possibly provid-ing a more extensive segmental spread. 55 Most of the literature available on ropivacaine is mainly dealing with epidural space administration with no studies on longterm intrathecal infusions.…”

Rationale and Technique for Single and Multiple Drug Combinations in Long‐term Intrathecal Infusions

“…b) Ropivacaine— The affinity of ropivacaine for A‐delta and C fibers makes this amide local anesthetic an excellent choice for providing analgesia without marked motor block 52,53 . This makes it very desirable when combination therapy is indicated.…”

“…This makes it very desirable when combination therapy is indicated. The theoretically better cardiotoxicity profile would make it a preferred choice over bupivacaine 52,54 . One more advantage is the lower lipid solubility as compared to bupivacaine, which makes the concentration in the CSF higher and possibly providing a more extensive segmental spread 55 .…”