Pharmacokinetics and Haemodynamics of Felodipine as Monotherapy in Hypertensive Patients

Edgar, Boo; Collste, P; Haglund, Kjell; Regårdh, C G

doi:10.2165/00003495-198700343-00006

Cited by 21 publications

(34 citation statements)

References 1 publication

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“…The mean terminal half-life after the oral dose (20.8 h) was comparable to that observed in hypertensive patients (Edgar et al, 1987a), but was longer than that in young individuals (14.4 h) (Edgar et al, 1985b). This difference was probably be an effect of age rather than disease (Landahl et al, 1988).…”

Section: Discussionsupporting

confidence: 55%

“…The values of clearance of felodipine in the renal failure patient were in the same range as in young healthy subjects and in hypertensive patients with normal renal function (Edgar et al, 1987a) as were the values volume of distribution (10.8 ± 3.5 1 kg-' (Edgar et al, 1985a, b). The mean terminal half-life after the oral dose (20.8 h) was comparable to that observed in hypertensive patients (Edgar et al, 1987a), but was longer than that in young individuals (14.4 h) (Edgar et al, 1985b).…”

Section: Discussionsupporting

confidence: 52%

“…In most subjects the maximum concentration was reached during the first hour, as was the case in healthy subjects (Edgar et al, 1987b) and in hypertensive patients (Edgar et al, 1985a). The mean bioavailability of 18.3%, was not significantly different from that in healthy subjects (16.2%) (Edgar et al, 1985c) and hypertensive patients (18.3%) (Edgar et al, 1987a).…”

Section: Discussionmentioning

confidence: 69%

“…Previous studies have shown that the t,, felodipine after oral and i.v. dosing is virtually the same (Edgar et al, 1987a, b). AUC(T-,) was determined by the log-linear trapezoidal rule; t was the time of the last measurable plasma sample.…”

Section: Calculationsmentioning

confidence: 99%

“…The pharmacokinetics of felodipine have previously been described in young healthy subjects and in patients with primary hypertension (Edgar et al, 1985b(Edgar et al, , 1987a following single dose administration. These studies have shown that felodipine is a high clearance drug extensively bound to plasma proteins.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics of felodipine in patients with impaired renal function.

Edgar

Regårdh

et al. 1989

Brit J Clinical Pharma

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1. The pharmacokinetics of felodipine and its effects on blood pressure and heart rate were studied in eight male patients aged between 28 and 57 years with a glomerular filtration rate, GFR, between 8 and 68 ml min‐1, following single i.v. and oral administration. 2. Clearance, Cmax, AUC, Vss and V, of felodipine were unaffected by the renal disease. The metabolite excretion (14C‐labelled) was slower than in healthy subjects. Initial renal clearance of these metabolites correlated with individual GFR values. The total amount of the dose excreted in the urine was also decreased.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 69%

Section: Calculationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics of felodipine in patients with impaired renal function.

Edgar

Regårdh

et al. 1989

Brit J Clinical Pharma

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Development of a high‐performance liquid chromatography method for simultaneous determination of pioglitazone and felodipine in pig serum: application to pharmacokinetic study

Palem

Gannu

Yamsani

et al. 2010

Biomedical Chromatography

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A simple and sensitive high-performance liquid chromatographic method was developed and validated for simultaneous estimation of pioglitazone and felodipine in pig serum. The present method consists of protein precipitation, extraction of analytes from pig serum into dichloromethane and separation using reversed-phase C(18) column. Nitrendipine was used as an internal standard and the eluent was monitored by UV detector at 240 nm. The mobile phase used was acetonitrile and 50 mm ammonium acetate buffer at a flow rate of 1 mL/min. The retention times for pioglitazone, felodipine and nitrendipine were found to be 5.12, 10.53 and 7.14 min, respectively. The intraday and inter-day coefficient of variation and percent error values of assay method were less than 7% and mean recovery was more than 94% for each analyte, and the method was found to be precise, accurate and specific during study. The method was successfully applied for pharmacokinetic study of pioglitazone and felodipine from bioadhesive buccal tablet after buccal administration to pigs. The C(Max) , T(Max) , and AUC(0-24) of pioglitazone and felodipine from buccal tablet were found to be 394.6 ng/mL, 5.6 h, 2624.2 ng h/mL and 44.4 ng/mL, 5.5 h, 275.8 ng h/mL, respectively.

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