Pharmacokinetics and intramuscular bioavailability of cefuroxime sodium in goats

Abo‐EL‐Sooud, Khaled; El-Banna, H. A.; Hanafy, M.; Goudah, A.

doi:10.1053/rvsc.2000.0412

Cited by 7 publications

(7 citation statements)

References 26 publications

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“…The distribution process was rapid but, moderate in its extension (high rate constant, short half‐life, and moderate volume of distribution). These pharmacokinetic parameters resulted rather similar to those reported for buffalo calves (Chaudhary et al ., ), goats (Abo El‐Sooud et al ., ), and dogs (Zhao et al ., ). Also, pharmacokinetic parameters evaluating elimination process (high clearance, short half‐life, and MRT) were very similar in the other studied species.…”

Section: Discussionmentioning

confidence: 97%

“…Observed cefuroxime pharmacokinetic profile after i.v. administration was the expected for a beta‐lactam and similar to that reported for dogs, goats, calves, and buffalo calves (Soback et al ., ; Chaudhary et al ., ; Abo El‐Sooud et al ., ; Zhao et al ., ) characterized by a fast distribution into the extracellular fluid and a relatively rapid renal excretion.…”

Section: Discussionmentioning

confidence: 99%

“…Cefuroxime pharmacokinetics has been studied in humans (Foord, 1976;Bundtzen et al, 1981), laboratory animals (Ryan et al, 1976;Ruiz-Carretero et al, 2000;Zhao et al, 2012a), goats (Abo El-Sooud et al, 2000;Prawez et al, 2001Prawez et al, , 2004, buffalo calves (Chaudhary et al, 1999), calves (Soback et al, 1989), and dogs (Zhao et al, 2012b). After i.v.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics of cefuroxime after intravenous, intramuscular, and subcutaneous administration to dogs

Albarellos

Montoya

Lorenzini

et al. 2015

Vet Pharm & Therapeutics

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Cefuroxime pharmacokinetic profile was investigated in 6 Beagle dogs after single intravenous, intramuscular, and subcutaneous administration at a dosage of 20 mg/kg. Blood samples were withdrawn at predetermined times over a 12-h period. Cefuroxime plasma concentrations were determined by HPLC. Data were analyzed by compartmental analysis. Peak plasma concentration (Cmax ), time-to-peak plasma concentration (Tmax ), and bioavailability for the intramuscular and subcutaneous administration were (mean ± SD) 22.99 ± 7.87 μg/mL, 0.43 ± 0.20 h, and 79.70 ± 14.43% and 15.37 ± 3.07 μg/mL, 0.99 ± 0.10 h, and 77.22 ± 21.41%, respectively. Elimination half-lives and mean residence time for the intravenous, intramuscular, and subcutaneous administration were 1.12 ± 0.19 h and 1.49 ± 0.21 h; 1.13 ± 0.13 and 1.79 ± 0.24 h; and 1.04 ± 0.23 h and 2.21 ± 0.23 h, respectively. Significant differences were found between routes for Ka , MAT, Cmax , Tmax , t½(a) , and MRT. T > MIC = 50%, considering a MIC of 1 μg/mL, was 11 h for intravenous and intramuscular administration and 12 h for the subcutaneous route. When a MIC of 4 μg/mL is considered, T > MIC = 50% for intramuscular and subcutaneous administration was estimated in 8 h.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics of cefuroxime after intravenous, intramuscular, and subcutaneous administration to dogs

Albarellos

Montoya

Lorenzini

et al. 2015

Vet Pharm & Therapeutics

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“…The pharmacokinetic properties of cefuroxime sodium have been determined in several species, including goats, calves, rats, and humans [5–9]. In most cases, a 2-compartment open model was considered to be the best model fitting the administration of cefuroxime sodium and which showed the values of t 1/2 to be 1.48 h after the intravenous or intramuscular injection of the antibiotic.…”

Section: Introductionmentioning

confidence: 99%

Bioequivalence and Population Pharmacokinetic Modeling of Two Forms of Antibiotic, Cefuroxime Lysine and Cefuroxime Sodium, after Intravenous Infusion in Beagle Dogs

Zhao

et al. 2012

Journal of Biomedicine and Biotechnology

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To investigate the bioequivalence and the population pharmacokinetics of cefuroxime lysine and cefuroxime sodium in healthy beagle dogs. A randomized 2-period crossover design in 18 healthy beagle dogs after receiving 20, 40, and 80 mg/kg of cefuroxime lysine or cefuroxime sodium was conducted. A 3-compartment open model was used as the basic model for the population pharmacokinetic study. Both of the antibiotics exhibited dose-proportional pharmacokinetics over the dose range of 20–80 mg/kg. The mean relative bioavailability of cefuroxime lysine versus cefuroxime sodium was 1.05 (range, 0.71 to 1.42), with a significant difference between males and females. The estimates of population pharmacokinetic of CL, V1, Q2, V2, Q3, V3 were 3.74 mL/h, 1.70 mL, 29.5 mL/min, 3.58 mL, 0.31 mL/min, and 158 mL for cefuroxime lysine and 4.10 mL/h, 1.00 mL, 38.5 mL/min, 4.19 mL, 0.06 mL/min, and 13.6 mL for cefuroxime sodium, respectively. The inter-individual variability was determined to be less than 29.1%. A linear pharmacokinetic was revealed for cefuroxime lysine and cefuroxime sodium in dogs after intravenous infusion, and the bioequivalence of these forms of the antibiotic was observed with the significant gender-related differences in mean relative bioavailability of cefuroxime lysine versus cefuroxime sodium.

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“…The two cefuroxime formulations currently used in clinic are the injectable cefuroxime sodium and cefuroxime axetil, for oral administration; both formulations must be converted into cefuroxime, in vivo, to act against most Gramnegative aerobic bacteria. There are numerous pharmacokinetic studies on cefuroxime sodium and cefuroxime axetil performed both in human beings and animals (rats, dogs, goats, and calves, etc) [4][5][6][7] . The elimination half-life in the studied species ranges from 0.5 to 2.3 h.…”

Section: Introductionmentioning

confidence: 99%

Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats

et al. 2012

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Aim:To compare the pharmacokinetic parameters of cefuroxime lysine, a new second-generation of cephalosporin antibiotics, after intravenous (IV), intraperitoneal (IP), or intramuscular (IM) administration. Methods: Twelve male and 12 virgin female Sprague-Dawley rats, weighing from 200 to 250 g, were divided into three groups (n=4 for each gender in each group). The rats were administered a single dose (67.5 mg/kg) of cefuroxime lysine via IV bolus or IP or IM injection. Blood samples were collected and analyzed with a validated UFLC-MS/MS method. The concentration-time data were then calculated by compartmental and non-compartmental pharmacokinetic methods using DAS software. Results: After IV, IP or IM administration, the plasma cefuroxime lysine disposition was best described by a tri-compartmental, bi-compartmental or mono-compartmental open model, respectively, with first-order elimination. The plasma concentration profiles were similar through the 3 administration routes. The distribution process was rapid after IV administration: the value of t 1/2(d) was 0.10±0.11 h, 1.36±0.65 h, and 1.25±1.01 h after IV, IP or IM administration. The AUMC 0-∞ is markedly larger, and mean residence time (MRT) is greatly longer after IP administration: the value of AUMC 0-∞ was 16.84±4.85, 55.33±20.34, and 36.17±13.24 mg·h 2 /L; the value of MRT was 0.37±0.07 h, 0.93±0.10 h, and 0.65±0.05 h after IV, IP or IM administration. The C max after IM injection was significantly higher than that in IP injection (73.51±12.46 vs 49.09±7.06 mg/L). There was no significantly sex-related difference in other pharmacokinetic parameters of cefuroxime lysine between male and female rats, except the value of AUC 0-∞ via IM administration that was significantly larger in male rats than that in female rats (66.38±16.5 vs 44.23±6.37 mg·h/L). Conclusion: Cefuroxime lysine shows quick absorption after IV injection, a long retension after IP injection, and a high C max after IM injection. After IM administration the AUC 0-∞ in male rats was significantly larger than that in female rats.

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Pharmacokinetics and intramuscular bioavailability of cefuroxime sodium in goats

Cited by 7 publications

References 26 publications

Pharmacokinetics of cefuroxime after intravenous, intramuscular, and subcutaneous administration to dogs

Pharmacokinetics of cefuroxime after intravenous, intramuscular, and subcutaneous administration to dogs

Bioequivalence and Population Pharmacokinetic Modeling of Two Forms of Antibiotic, Cefuroxime Lysine and Cefuroxime Sodium, after Intravenous Infusion in Beagle Dogs

Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats

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