Pharmacokinetics and Pharmacodynamics During Cardiac Surgery and Cardiopulmonary Bypass

The Fate of Von Willebrand Factor Concentrate During Cardiopulmonary Bypass: A Case Report

“…Hemodilution carries the consequences of limiting oxygen availability, changing viscosity and oncotic pressure, and diluting immunoglobulins [10]. Importantly, the effective increased volume of distribution when the patient's blood volume is mixed with the CPB circuit priming solution decreases coagulation factor levels leading to clinically significant post-bypass bleeding [11,12]. Just as the patient's native coagulation factors are exposed to dilution by the priming volume, one would expect the prepared factor concentrates the are supplemented prior to CPB would also undergo dilution.…”