Pharmacokinetics and pharmacodynamics – is there anything new?

Rigby-Jones, A. E.; Sneyd, J. R.

doi:10.1111/j.1365-2044.2011.06993.x

Cited by 8 publications

(3 citation statements)

References 37 publications

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“…The principles of pharmacokinetic/pharmacodynamic modelling have been explained in detail by Rigby‐Jones and Sneyd in this journal . The aim of this editorial is to help clinicians to understand some important differences between currently available propofol effect‐site models, focusing on the relevance of the k e0 .…”

Section: Current Controversy With Propofol Effect‐site Modelsmentioning

confidence: 99%

What is the k_e0 and what does it tell me about propofol?

Cortínez

2014

Anaesthesia

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Section: Current Controversy With Propofol Effect‐site Modelsmentioning

confidence: 99%

What is the k_e0 and what does it tell me about propofol?

Cortínez

2014

Anaesthesia

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“…Cardiac output (CO) [3,108] and administration mode (bolus or infusion) [91] were also found to influence the time and dose required for propofol anaesthesia. However, some of these factors could not be incorporated into the standard compartmental model [83] due to oversimplified assumptions and structure limitation.…”

Section: Model Uncertaintymentioning

confidence: 98%

Automation of anaesthesia: a review on multivariable control

Chang

Syafiie

Kamil

et al. 2014

J Clin Monit Comput

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Anaesthesia is a multivariable problem where a combination of drugs are used to induce desired hypnotic, analgesia and immobility states. The automation of anaesthesia may improve the safety and cost-effectiveness of anaesthesia. However, the realization of a safe and reliable multivariable closed-loop control of anaesthesia is yet to be achieved due to a manifold of challenges. In this paper, several significant challenges in automation of anaesthesia are discussed, namely model uncertainty, controlled variables, closed-loop application and dependability. The increasingly reliable measurement device, robust and adaptive controller, and better fault tolerance strategy are paving the way for automation of anaesthesia.

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“…This has been attributed to the nonlinear relationship between weight and clearance. Although lean body weight has been proposed as the ideal measure for propofol [55,56], allometric scaling using total body weight with an exponent of 0.75 may be more appropriate [6,57]. This same exponent has been advocated for the clearance of propofol in obese adults [58] and children [59] although a recent analysis suggested an exponent of 0.8 in obese children may be superior [60 • ].…”

Section: Propofolmentioning

confidence: 99%

Unraveling Pharmacokinetics and Pharmacodynamics in Infants and Children

Sumpter¹,

Anderson

2012

Curr Anesthesiol Rep

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Our knowledge of the pharmacology of the drugs used in pediatric anesthesia has advanced with a greater understanding of their pharmacokinetics (PK) and pharmacodynamics. This has resulted in a refinement of their uses, broader indications, and alternative methods of delivery. For example, methadone is becoming increasingly popular for spinal surgery, the dosing of etomidate has been clarified and the PK of intravenous acetaminophen from neonates to adults has been revealed. Morphine PK have also been clarified, although pharmacodynamic ethnic differences remain unexplained. The optimal size descriptor to predict correct drug doses in the obese remains controversial. Efforts to reduce adverse effects of individual drugs have spawned investigations into beneficial drug interactions, although combinations such as propofol and ketamine await PK and safety review. The nasal route may be a reasonable alternative to intravenous administration for many drugs. Oral ketamine may serve as a valuable premedication for children suffering burns. Expanded indications can have unfavorable consequences; propofol may cause profound hypotension in neonates.

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Pharmacokinetics and pharmacodynamics – is there anything new?

Cited by 8 publications

References 37 publications

What is the k_e0 and what does it tell me about propofol?

What is the k_e0 and what does it tell me about propofol?

Automation of anaesthesia: a review on multivariable control

Unraveling Pharmacokinetics and Pharmacodynamics in Infants and Children

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Pharmacokinetics and pharmacodynamics – is there anything new?

Cited by 8 publications

References 37 publications

What is the ke0 and what does it tell me about propofol?

What is the ke0 and what does it tell me about propofol?

Automation of anaesthesia: a review on multivariable control

Unraveling Pharmacokinetics and Pharmacodynamics in Infants and Children

Contact Info

Product

Resources

About

What is the k_e0 and what does it tell me about propofol?

What is the k_e0 and what does it tell me about propofol?