Pharmacokinetics and pharmacodynamics of sulfamethoxazole and trimethoprim in swimming crabs ( Portunus trituberculatus ) and in vitro antibacterial activity against Vibrio: PK / PD of SMZ-TMP in crabs and antibacterial activity against Vibrio

Fu, Guohua; Jia-hong, Peng; Yuan, Wei; Fang, Wenhong; Hu, Kun; Shen, Jinyu; Yao, Jiayun

doi:10.1016/j.etap.2016.06.029

Cited by 26 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antimicrobial peptides contained in the hemolymph of shrimp have antibacterial activity. An increased antimicrobial peptide content can enhance the shrimp’s ability to resist pathogenic infection [ 41 ]. In this study we found that, compared with the infection only group, the antibacterial activities in the drug treatment groups were significantly higher.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Combined Utilization of Quercetin and Florfenicol on Acute Hepatopancreatic Necrosis Syndrome Infected Litopenaeus vannamei

Zhai

Chang

et al. 2022

Antibiotics

View full text Add to dashboard Cite

This study aimed to determine the immunity, survival rate, and disease resistance of Litopenaeus vannamei treated using quercetin and florfenicol alone or in combination, after infection with acute hepatopancreatic necrosis syndrome caused by Vibrio parahaemolyticus (VPAHPND). After infection with VPAHPND, different types of feed were given to the shrimp for 5 days, including a control diet (drug-free), florfenicol only diet (15 mg/kg), quercetin only diet (400 mg/kg), a low-dose florfenicol/quercetin combined diet (200 mg/kg quercetin + 7.0 mg/kg florfenicol), a moderate-dose florfenicol/quercetin combined diet (400 mg/kg quercetin + 15 mg/kg florfenicol), and a high-dose florfenicol/quercetin combined diet (800 mg/kg quercetin + 30 mg/kg florfenicol). The cumulative mortality of shrimp was significantly reduced in the drug combination groups compared with either drug used alone (p < 0.05). The density of Vibrio was significantly lower and the immune parameters were significantly increased in the drug combination groups compared with either drug used alone (p < 0.05). Moreover, in the drug combination groups, the hepatopancreas tubules showed better integrity and structure compared with those when either drug was used alone. Therefore, compared with single drug treatment, the florfenicol and quercetin combination enhanced disease resistance, survival, and immune activity of VPAHPND-infected shrimp. When the combination treatment is used, the dosage of florfenicol can be reduced and a better therapeutic effect is obtained.

show abstract

Section: Discussionmentioning

confidence: 99%

Protective Effects of Combined Utilization of Quercetin and Florfenicol on Acute Hepatopancreatic Necrosis Syndrome Infected Litopenaeus vannamei

Zhai

Chang

et al. 2022

Antibiotics

View full text Add to dashboard Cite

show abstract

“…Alsaad established the optimal dosage of TMP/SMZ for the treatment of human Mycobacterium tuberculosis infection through PK-PD research [ 73 , 74 ]. It has also been reported that TMP/SMZ is used in the treatment of bacterial infections of aquatic organisms, e.g., Portunus trituberculatus [ 75 ]. Wang studied the pharmacokinetics of ADP/SMZ in porcine plasma and ileum contents.…”

Section: Discussionmentioning

confidence: 99%

Dosing Regimen of Aditoprim and Sulfamethoxazole Combination for the Glaesserella parasuis Containing Resistance and Virulence Genes

Huang

Zhang

et al. 2022

Pharmaceutics

View full text Add to dashboard Cite

Glaesserella parasuis (G. parasuis) causes Glasser’s disease in pigs and causes high mortality in piglets. The new drug Aditoprim (ADP) alone or combined with Sulfamethoxazole (SMZ) is one of the good choices for treating respiratory infections. The objective of this study was to recommend the optimal dosing regimen for the treatment of G. parasuis infection which contains resistance and virulence genes by ADP/SMZ compound through pharmacokinetics–pharmacodynamics (PK-PD) modeling. The whole genome of the virulent strain G. parasuis H78 was obtained and annotated by whole genome sequencing. The results show that G. parasuis H78 consists of a unilateral circular chromosome with prophages in the genome. The annotation results of G. parasuis H78 showed that the genome contained a large number of virulence-related genes and drug resistance-related genes. The in vitro PD study showed that the antibacterial effect of ADP/SMZ compound against G. parasuis was time-dependent, and AUC/MIC was selected as the PK-PD modeling parameter. The PK study showed that the content of ADP/SMZ compound in pulmonary epithelial lining fluid (PELF) was higher than plasma, and there were no significant differences in ADP and SMZ PK parameters between the healthy and infected group. The dose equation to calculate the optimal dosing regimen of ADP/SMZ compound administration for control of G. parasuis infection was 5/25 mg/kg b.w., intramuscular injection once a day for 3~5 consecutive days. The results of this study provide novel therapeutic options for the treatment of G. parasuis infection to decrease the prevalence and disease burden caused by G. parasuis.

show abstract

“…The pharmacokinetics of SMZ-TMP have been previously evaluated in a variety of mammals, [9][10][11][12][13] invertebrates, 14,15 pigeons, 16 and egg-laying hens. 17 In a previous study in chickens, a single oral and intravenous dose of a compounded SMZ-TMP product with a different SMZ-TMP ratio than the commercially available product was administered; however, safety and the effects of repeated dosing were not evaluated.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and Safety of Sulfamethoxazole-Trimethoprim After Oral Administration of Single and Multiple Doses to Rhode Island Red Chickens (Gallus gallus domesticus)

Petritz¹,

Enomoto²,

Meyer³

et al. 2023

Journal of Avian Medicine and Surgery

View full text Add to dashboard Cite

Pharmacokinetics and pharmacodynamics of sulfamethoxazole and trimethoprim in swimming crabs ( Portunus trituberculatus ) and in vitro antibacterial activity against Vibrio: PK / PD of SMZ-TMP in crabs and antibacterial activity against Vibrio

Cited by 26 publications

References 23 publications

Protective Effects of Combined Utilization of Quercetin and Florfenicol on Acute Hepatopancreatic Necrosis Syndrome Infected Litopenaeus vannamei

Protective Effects of Combined Utilization of Quercetin and Florfenicol on Acute Hepatopancreatic Necrosis Syndrome Infected Litopenaeus vannamei

Dosing Regimen of Aditoprim and Sulfamethoxazole Combination for the Glaesserella parasuis Containing Resistance and Virulence Genes

Pharmacokinetics and Safety of Sulfamethoxazole-Trimethoprim After Oral Administration of Single and Multiple Doses to Rhode Island Red Chickens (Gallus gallus domesticus)

Contact Info

Product

Resources

About