Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines

Agwuh, Kenneth N.; MacGowan, Alasdair

doi:10.1093/jac/dkl224

Cited by 683 publications

(530 citation statements)

References 45 publications

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“…Its rapid distribution into tissues [15] may expose parasite populations to a prolonged period of subtherapeutic concentrations, thus increasing the risk of resistance. In addition, the need for intravenous administration restricts the use of tigecycline to hospitalised patients.…”

Section: Page 9 Of 16mentioning

confidence: 99%

In vitro activity of tigecycline in Plasmodium falciparum culture-adapted strains and clinical isolates from Gabon

Held¹,

Zanger²,

Issifou³

et al. 2010

International Journal of Antimicrobial Agents

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In vitro activity of tigecycline in Plasmodium falciparum culture-adapted strains and clinical isolates from Gabon. International Journal of Antimicrobial Agents, Elsevier, 2010, 35 (6) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. nM) for clindamycin. Tigecycline was found to act faster against plasmodia than any of the other antibiotics tested. This study demonstrates the potential of tetracycline derivatives in the development of improved antimalarials.

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Section: Page 9 Of 16mentioning

confidence: 99%

In vitro activity of tigecycline in Plasmodium falciparum culture-adapted strains and clinical isolates from Gabon

Held¹,

Zanger²,

Issifou³

et al. 2010

International Journal of Antimicrobial Agents

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“…It also has a longer half-life, and it can be used twice a day. 14 In a study comparing arms with tetracycline and doxycycline, both arms had similar eradication rates. 15 The main difference in antimicrobial resistance between the two drugs is that doxycycline can inhibit some tetracycline resistant Gram-positive bacteria.…”

Section: Discussionmentioning

confidence: 99%

Furazolidona, tetraciclina e omeprazol: uma alternativa de baixo custo para erradicação de Helicobacter pylori em crianças

Machado¹,

Silva²,

Viriato³

2008

J. Pediatr. (Rio J.)

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Objectives: To evaluate furazolidone, tetracycline and omeprazole as first line therapy for Helicobacter pylori in children with digestive symptoms. Methods:Prospective and consecutive open trial. The study included patients older than 8 years old with functional dyspepsia, functional abdominal pain, severe histological abnormalities (intestinal metaplasia, gastric atrophy or mucosa-associated lymphoid tissue lymphoma) or peptic ulcer. H. pylori status was defined based both upon histology and rapid urease test. Drug regimen was a 7-day course of omeprazol, tetracycline (or doxycycline) and furazolidone twice daily. Eradication was assessed by upper endoscopy 2 months after treatment (histology and rapid urease test).Further clinical evaluation was done 7 days and 2 months after treatment.Results: Thirty-six patients (21 female/15 male) were included. Age ranged from 8 to 19 years (mean 12.94±2.89 years). On intention-to-treat analysis (n = 36), eradication rate was 83.3% (95%CI 77.1-89.5) whereas in per-protocol analysis (n = 29), it was 89.7% (95%CI 84.6-94.7). Compliance was better when doxycycline was used, but the success rates were similar for the two tetracyclines. There was no variable associated with treatment failure. Side effects were reported in 17 patients (47.2%), mainly abdominal pain (11/30.5%), nausea (seven/19.4%) and vomiting (five/ 13.9%). Conclusion:Triple therapy with furazolidone and tetracycline is a low-cost alternative regimen to treat H. pylori infection.J Pediatr (Rio J). 2008;84(2):160-165: Furazolidone, tetracycline, Helicobacter pylori treatment, child, clinical trial.

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“…It is more lipophilic than older tetratcyclines, resulting in rapid tissue distribution [7,8]. Because of its rapid absorption and long half-life, minocycline is commonly used as an adjunctive treatment for acne and rosacea [9].…”

Section: What Is the Clinical Spectrum Of Tetracycline-induced Skin Cmentioning

confidence: 99%

Minocycline Toxicity: Case Files of the University of Massachusetts Medical Toxicology Fellowship

2012

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A 61-year-old man was brought to the emergency department (ED) for shortness of breath, fatigue, frequent falls, and bluish discoloration of his skin. The primary care physician transferred the patient due to concern for cyanosis. On presentation to the ED, the patient was oriented but appeared fatigued. The patient was afebrile and had the following vital signs: blood pressure 161/88 mmHg, pulse 71/min, respiratory rate 16/min, and oxygen saturation 100 % on room air by fingertip pulse oximetry. On physical exam, pupils were 4 mm and reactive bilaterally, extraocular movements were intact, and there was no nystagmus. Anicteric sclerae were notable for blue pigmentation (Fig. 1). Heart sounds were regular, without murmurs, rubs, or gallops. Lung sounds were clear to auscultation bilaterally. Other than ataxia, the neurological exam was unremarkable. The skin had a generalized bluish tinge, especially on the arms, with darker pigmentation on the cheeks (Figs. 2, 3 and 4). There was acne on the back and facial rosacea. Bluish discoloration was also noted under the proximal nail beds (Fig. 5). When questioned about the skin discoloration, the patient and his family members described an insidious onset. Photographs of the patient from years ago confirmed that this was not congenital. Medical history included acne, orthostatic hypotension, and Parkinson's disease, for which a deep brain stimulator had been surgically implanted. A comprehensive medication list was not immediately available; however, the patient denied any recent medication additions or adjustments. The patient was unemployed, denied any recent travel, and no other members of his household were complaining of fatigue or similar blue skin discoloration.

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Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines

Cited by 683 publications

References 45 publications

In vitro activity of tigecycline in Plasmodium falciparum culture-adapted strains and clinical isolates from Gabon

In vitro activity of tigecycline in Plasmodium falciparum culture-adapted strains and clinical isolates from Gabon

Furazolidona, tetraciclina e omeprazol: uma alternativa de baixo custo para erradicação de Helicobacter pylori em crianças

Minocycline Toxicity: Case Files of the University of Massachusetts Medical Toxicology Fellowship

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