Pharmacokinetics and Target Attainment of ß-lactam Antibiotics in Older People: A Systematic Review of Current Literature

Vervalcke, Jeroen; Clercq, Arnaud De; Paepe, Peter De; Petrovic, Mirko; Desmet, Tania; Cock, Pieter De

doi:10.1007/s40262-022-01196-1

Clin Pharmacokinet

2023

DOI: 10.1007/s40262-022-01196-1

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Pharmacokinetics and Target Attainment of ß-lactam Antibiotics in Older People: A Systematic Review of Current Literature

Jeroen Vervalcke

Arnaud De Clercq

Peter De Paepe

et al.

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Cited by 3 publications

(2 citation statements)

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“…10,11 Several studies have demonstrated that age plays a crucial role in the pharmacokinetics of voriconazole. 12,13 The study conducted by Niioka et al revealed that older Japanese patients exhibited elevated voriconazole trough concentration levels. Additionally, age was identified as a significant predictor for voriconazole trough levels surpassing 5 mg/L.…”

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Population Pharmacokinetics of Voriconazole and Dose Optimization in Elderly Chinese Patients

Wang,

Shen,

et al. 2023

The Journal of Clinical Pharma

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Voriconazole is commonly recommended as a first‐line therapy for invasive aspergillosis infections. The elderly patients are susceptible to infectious diseases owing to their decreased physical function and immune system. Our study aims to establish a population‐based pharmacokinetic model for receiving intravenous voriconazole of elderly patients, and to optimize dosing protocols through a simulated approach. An accurate fit to the concentration‐time profile of voriconazole was achieved by employing a one‐compartment model featuring first‐order elimination. The typical clearance rate of voriconazole was found to be 3.22 L/h, with a typical volume of distribution of 194 L. The covariate analysis revealed that albumin (ALB), gamma glutamyl transpeptidase, and direct bilirubin had significant impacts on voriconazole clearance. Additionally, the body weight was found to be associated with the volume. Individualized dosing regimens were recommended for different ALB levels based on population PK model prediction. The proposed dosing regimens could provide a rationale for dosage individualization, improve the clinical outcomes and minimize drug‐related toxicities.This article is protected by copyright. All rights reserved

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confidence: 99%

“…Several studies have demonstrated that age plays a crucial role in the pharmacokinetics of voriconazole 12,13 . The study conducted by Niioka et al revealed that older Japanese patients exhibited elevated voriconazole trough concentration levels.…”

mentioning

confidence: 99%

Population Pharmacokinetics of Voriconazole and Dose Optimization in Elderly Chinese Patients

Wang,

Shen,

et al. 2023

The Journal of Clinical Pharma

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Have We Neglected to Study Target-Site Drug Exposure in Children? A Systematic Review of the Literature

Hermans,

Meersschaut,

Van herteryck

et al. 2024

Clin Pharmacokinet

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Appropriate use of antibiotics for oral/dental conditions in older adults: a narrative review

Đukić,

Soulis,

Janssens

et al. 2024

Acta Clinica Belgica

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Pharmacokinetics and Target Attainment of ß-lactam Antibiotics in Older People: A Systematic Review of Current Literature

Cited by 3 publications

References 95 publications

Population Pharmacokinetics of Voriconazole and Dose Optimization in Elderly Chinese Patients

Population Pharmacokinetics of Voriconazole and Dose Optimization in Elderly Chinese Patients

Have We Neglected to Study Target-Site Drug Exposure in Children? A Systematic Review of the Literature

Appropriate use of antibiotics for oral/dental conditions in older adults: a narrative review

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