Pharmacokinetics and Tissue Distribution of Etoposide Delivered in Parenteral Emulsion

Patlolla, Ram R.; Venkateswarlu, Vobalaboina

doi:10.1002/jps.20249

Cited by 55 publications

(47 citation statements)

References 38 publications

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“…This means that for low concentration of Etoposide (< 50 μM) we can use the linear approximation proposed in this model. And in many clinical applications Etoposide is administered at concentration in the range 1-40 μM, as in [14] and in the more recent [15], [16].…”

Section: Problem Modelingmentioning

confidence: 99%

A Linear Approach to Multi-Panel Sensing in Personalized Therapy for Cancer Treatment

2013

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Abstract-In this paper, a new approach for evaluating the performance of a multi-panel biosensor using linear algebra is presented. With a system-level mathematical analysis based on graphs and linear algebra, we formulate a new approach for contributions decoupling in a multi-panel biochip for simultaneous detection of anti-cancer drugs, avoiding redundancy and interaction between enzymes. Experimental results have been used to validate the model. Index Terms-Cytochrome P450 biosensor, multiplexed drugs detection, personalized therapy, condition number, limit of detection, linear system.

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Section: Problem Modelingmentioning

confidence: 99%

A Linear Approach to Multi-Panel Sensing in Personalized Therapy for Cancer Treatment

2013

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“…Nanoemulsion dosage forms have found wide applications in oral drug delivery to enhance the solubility and bioavailability of the hydrophobic drugs (4,10,11). Recently, there has been a surge in the exploration of nanoemulsions for parenteral drug delivery for the treatment of complex diseases such as cancer therapy (2,3,(5)(6)(7)(8)(9)12). The capacity of nanoemulsion to solubilize large amounts of hydrophobic drugs and their ability to protect the drugs from enzymatic degradation and hydrolysis make them ideal platform for the purpose of parenteral drug delivery.…”

Section: Introduction-applications Of Nanoemulsions In Drug Deliverymentioning

confidence: 99%

“…However, it is important that the nanoemulsions do not change size after administration during the blood circulation. Recent studies indicate that they have received wide attention as colloidal carriers for targeted delivery of several anticancer drugs (2,5,7,12) and diagnostic agents (13,19). Multifunctional nanoparticles, as envisioned by Ferrari (20) and other researchers (21,22), combine the following structural components: (1) core material for drug encapsulation (2), and surface modification for passive or active targeting and (3) imaging component for disease visualization.…”

Section: Introduction-applications Of Nanoemulsions In Drug Deliverymentioning

confidence: 99%

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

et al. 2014

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Abstract. Nanoemulsion dosage form serves as a vehicle for the delivery of active pharmaceutical ingredients and has attracted great attention in drug delivery and pharmacotherapy. In particular, nanoemulsions act as an excellent vehicle for poorly aqueous soluble drugs, which are otherwise difficult to formulate in conventional dosage forms. Nanoemulsions are submicron emulsions composed of generally regarded as safe grade excipients. Particle size at the nanoscale and larger surface area lead to some very interesting physical properties that can be exploited to overcome anatomical and physiological barriers associated in drug delivery to the complex diseases such as cancer. Along these lines, nanoemulsions have been engineered with specific attributes such as size, surface charge, prolonged blood circulation, target specific binding ability, and imaging capability. These attributes can be tuned to assist in delivering drug/imaging agents to the specific site of interest, based on active and passive targeting mechanisms. This review focuses on the current state of nanoemulsions in the translational research and its role in targeted cancer therapy. In addition, the production, physico-chemical characterization, and regulatory aspects of nanoemulsion are addressed.

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“…The potential pharmaceutical applications include use as a carrier for lipophilic drugs [7][8][9][10][11] and for site-specific drug delivery by attaching ligands for various cell surface receptors to the particle surface. 12) Generally, intravenous emulsions are biodegradable, biocompatible, physically stable, easy to scale up and cost effective when compared to other drug carriers.…”

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confidence: 99%

Formulation, Characterization and Hypersensitivity Evaluation of an Intravenous Emulsion Loaded with a Paclitaxel-Cholesterol Complex

Xia

Guo

Liu

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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The objective of this paper was to develop a novel Cremophor-free, autoclave stable, intravenous emulsion for paclitaxel (PACE). A paclitaxel-cholesterol complex was used as the drug carrier to improve the solubility of paclitaxel in the oil phase of emulsions. The complex and PACE were prepared by rotary evaporation and highpressure homogenization, respectively. Effects of oil phases, emulsifiers and pH values on the characteristics of PACE were investigated. PACE was characterized with regard to its appearance, morphology, osmolality, pH value, particle size, zeta potential, encapsulation efficiency and stability. Hypersensitivity was evaluated by guinea pig hypersensitivity reaction. The final formulation was composed of the complex, soybean oil, mediumchain triglyceridel, soybean lecithin, poloxamer 188 and glycerol. The resulting PACE had an encapsulation efficiency of 97.3% with a particle size of 135 nm and a zeta potential of ؊38.3 mV. Osmolality and pH of the formulation were 383 mOsmol/kg and 4.5, respectively. The formulation survived autoclaving at 115°C for 30 min and remained stable for at least 12 months at 6°C. PACE also exhibited a better tolerance than an equal dose of Cremophor-based paclitaxel injection in guinea pigs, as no obvious hypersensitivity reaction was observed. These results suggested that PACE has a great potential for industrial-scale production and clinical applications.

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Pharmacokinetics and Tissue Distribution of Etoposide Delivered in Parenteral Emulsion

Cited by 55 publications

References 38 publications

A Linear Approach to Multi-Panel Sensing in Personalized Therapy for Cancer Treatment

A Linear Approach to Multi-Panel Sensing in Personalized Therapy for Cancer Treatment

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

Formulation, Characterization and Hypersensitivity Evaluation of an Intravenous Emulsion Loaded with a Paclitaxel-Cholesterol Complex

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