Pharmacokinetics and Tissue Uptake of Doxorubicin Associated With Erythroctte-nembrane:erithroctte-Ghosts vs Erythrocyte-Vesicles

Al-Achi, Antoine; Boroujerdi, Mehdi

doi:10.3109/03639049009043795

Cited by 11 publications

(7 citation statements)

References 6 publications

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“…It is quicker and cheaper method in comparison with other two. Al-Achi et al [95,96] have successfully reported erythrocyte membrane vesicular delivery of insulin and doxorubicin. Electrical breakdown method is used to convert ghosts into small vesicles under the influence of electrical potential.…”

Section: Nanoerythrosomes [Nes]mentioning

confidence: 99%

Drug Loaded Erythrocytes: As Novel Drug Delivery System

Patel¹,

Dand²,

Hirlekar³

et al. 2008

CPD

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Novel drug delivery systems are one of the widely used delivery systems. In the present scenario, amongst them, "Drug Loaded Erythrocytes" is one of the growing and potential systems for delivery of drugs and enzymes. Erythrocytes are biocompatible, biodegradable, possess long circulation half-life and can be loaded with variety of biologically active substances. Carrier erythrocytes are prepared by collecting blood sample from the organism of interest and separating erythrocytes from plasma. By using various physical and chemical methods the cells are broken and the drug is entrapped into the erythrocytes, finally they are resealed and the resultant carriers are then called "resealed erythrocytes". Surface modification with glutaraldehyde, antibodies, carbohydrates like sialic acid and biotinylation of loaded erythrocytes (biotinylated erythrocytes) is possible to improve their target specificity and to increase their circulation half-life. Upon reinjection the drug loaded erythrocytes serve as slow circulation depots, targets the drug to the reticuloendothelial system (RES), prevents degradation of loaded drug from inactivation by endogenous chemicals, attain steady state concentration of drug and decrease the side-effects of loaded drug. Nowadays, Nanoerythrosomes based drug delivery systems have excellent potential for clinical application.

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Section: Nanoerythrosomes [Nes]mentioning

confidence: 99%

Drug Loaded Erythrocytes: As Novel Drug Delivery System

Patel¹,

Dand²,

Hirlekar³

et al. 2008

CPD

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“…Erythrocytes has been used as circulating intravenous (IV) slow release carriers for the delivery of antineoplasms (16,26,35,41,45,62,(79)(80)(81), antiparasitics (20,40,47), antibabesiosis agents (in veterinary) (5), vitamins (70), steroids (24,32,38), antibiotics (31,60,65), and cardiovascular drugs (33,34,75).…”

Section: Intravenous Slow Drug Releasementioning

confidence: 99%

“…2. Treatment of hepatic tumors which is one of the most prevalent types of neoplasms; erythrocytes loaded by the antineoplasm agents adriamycin (5,35,80,92), bleomycin (5), asparaginase (5,16), and methotrexate (4,5) have been tested successfully in treatment of the experimental tumors in animal models. 3.…”

Section: Targeted Drug Deliverymentioning

confidence: 99%

Carrier Erythrocytes: An Overview

2003

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Application of erythrocytes, the most abundant cells of the human body with desirable physiologic and morphologic characteristics, in drug delivery has been exploited extensively. These cellular carriers, having remarkable biocompatibility, biodegradability, and life-span in circulation, can be loaded by a wide spectrum of compounds of therapeutic value using different chemically, as well as physically, based methods. Most of the characteristics of the erythrocytes, including shape, membrane fragility, deformability, and hematologic indices undergo some degree of irreversible changes during the loading procedure. The efflux pattern of the encapsulated compounds from the carrier erythrocytes covers a wide range between a relatively rapid release (complete release within a few hours) and no detectable release until the cell lysis. A series of methods have been tested successfully for improvement of in vitro storability of the carrier erythrocytes without any significant changes in cell biology as well as drug delivery efficacy. Carrier erythrocytes have been exploited for several potential applications, including intravenous slow release of therapeutic agents, enzyme therapy, drug targeting to reticuloendothelial system (RES), improvement of oxygen delivery to tissues, and preparation of fused cells.

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“…21,23 These "erythrosomes" (also called "ghosts") were about the same size as the original cells (i.e., around 4 μm in diameter). More recently, in the 1990s, nanoscale analogues of these ghosts were reported by Al-Achi and Boroujerdi 25 and by Lejeune et al; 26−29 the latter group coined the term "nanoerythrosome" (NER) for these structures. NERs were created by these authors by subjecting the microscale ghosts to a high-shear process, i.e., sonication or extrusion.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The idea of using erythrocytes as carriers for a substance other than (or in addition to) hemoglobin dates back to the 1950s. − Erythrocytes were partially or completely emptied by exposure to hypotonic conditions, and filled with drugs or enzymes. , These “erythrosomes” (also called “ghosts”) were about the same size as the original cells (i.e., around 4 μm in diameter). More recently, in the 1990s, nanoscale analogues of these ghosts were reported by Al-Achi and Boroujerdi and by Lejeune et al; − the latter group coined the term “nanoerythrosome” (NER) for these structures. NERs were created by these authors by subjecting the microscale ghosts to a high-shear process, i.e., sonication or extrusion.…”

Section: Introductionmentioning

confidence: 99%

Colloidal Properties of Nanoerythrosomes Derived from Bovine Red Blood Cells

Kuo

Hoang

et al. 2015

Langmuir

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Liposomes are nanoscale containers that are typically synthesized from lipids using a high-shear process such as extrusion or sonication. While liposomes are extensively used in drug delivery, they do suffer from certain problems including limited colloidal stability and short circulation times in the body. As an alternative to liposomes, we explore a class of container structures derived from erythrocytes (red blood cells). The procedure involves emptying the inner contents of these cells (specifically hemoglobin) and resuspending the empty structures in buffer, followed by sonication. The resulting structures are termed nanoerythrosomes (NERs), i.e., they are membrane-covered nanoscale containers, much like liposomes. Cryo-transmission electron microscopy (cryo-TEM) and small-angle neutron scattering (SANS) are employed for the first time to study these NERs. The results reveal that the NERs are discrete spheres (∼110 nm diameter) with a unilamellar membrane of thickness ∼4.5 nm. Remarkably, the biconcave disc-like shape of erythrocytes is also exhibited by the NERs under hypertonic conditions. Moreover, unlike typical liposomes, NERs show excellent colloidal stability in both buffer as well as in serum at room temperature, and are also able to withstand freeze-thaw cycling. We have explored the potential for using NERs as colloidal vehicles for targeted delivery. Much like conventional liposomes, NER membranes can be decorated with fluorescent or other markers, solutes can be encapsulated in the cores of the NERs, and NERs can be targeted to specifically bind to mammalian cells. Our study shows that NERs are a promising and versatile class of nanostructures. NERs that are harvested from a patient's own blood and reconfigured for nanomedicine can potentially offer several benefits including biocompatibility, minimization of immune response, and extended circulation time in the body.

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Pharmacokinetics and Tissue Uptake of Doxorubicin Associated With Erythroctte-nembrane:erithroctte-Ghosts vs Erythrocyte-Vesicles

Cited by 11 publications

References 6 publications

Drug Loaded Erythrocytes: As Novel Drug Delivery System

Drug Loaded Erythrocytes: As Novel Drug Delivery System

Carrier Erythrocytes: An Overview

Colloidal Properties of Nanoerythrosomes Derived from Bovine Red Blood Cells

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