Pharmacokinetics and transplacental transfer of codeine and codeine metabolites from Papaver somniferum L.

Chen, Jung-Hung; Lin, I-Hsin; Hsueh, Ting-Jen; Dalley, Jeffrey W.; Tsai, Tung Hu

doi:10.1016/j.jep.2022.115623

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…HPLC-MS/MS was also utilized to determine the levels of legacy per- and polyfluoroalkyl substances in 50 paired samples of maternal and cord serum of pregnant women at delivery [ 74 ]. Moreover, UHPLC-MS/MS combined with a microdialysis system was developed to monitor codeine, morphine, and morphine-3-glucuronide in multiple sites of maternal blood, placenta, fetus, and amniotic fluid after codeine administration [ 75 ]. Notably, nano-LC-MS/MS was applied to determine nutrient transport expression in human fetal membranes and fetal membrane cells and compared expression with placental tissues and BeWo cells [ 76 ].…”

Section: Resultsmentioning

confidence: 99%

Fetus Exposure to Drugs and Chemicals: A Holistic Overview on the Assessment of Their Transport and Metabolism across the Human Placental Barrier

Kotta-Loizou,

Pritsa,

Antasouras

et al. 2024

Diseases

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Background: The placenta exerts a crucial role in fetus growth and development during gestation, protecting the fetus from maternal drugs and chemical exposure. However, diverse drugs and chemicals (xenobiotics) can penetrate the maternal placental barrier, leading to deleterious, adverse effects concerning fetus health. Moreover, placental enzymes can metabolize drugs and chemicals into more toxic compounds for the fetus. Thus, evaluating the molecular mechanisms through which drugs and chemicals transfer and undergo metabolism across the placental barrier is of vital importance. In this aspect, this comprehensive literature review aims to provide a holistic approach by critically summarizing and scrutinizing the potential molecular processes and mechanisms governing drugs and chemical transfer and metabolism across the placental barrier, which may lead to fetotoxicity effects, as well as analyzing the currently available experimental methodologies used to assess xenobiotics placental transfer and metabolism. Methods: A comprehensive and in-depth literature review was conducted in the most accurate scientific databases such as PubMed, Scopus, and Web of Science by using relevant and effective keywords related to xenobiotic placental transfer and metabolism, retrieving 8830 published articles until 5 February 2024. After applying several strict exclusion and inclusion criteria, a final number of 148 relevant published articles were included. Results: During pregnancy, several drugs and chemicals can be transferred from the mother to the fetus across the placental barrier by either passive diffusion or through placental transporters, resulting in fetus exposure and potential fetotoxicity effects. Some drugs and chemicals also appear to be metabolized across the placental barrier, leading to more toxic products for both the mother and the fetus. At present, there is increasing research development of diverse experimental methodologies to determine the potential molecular processes and mechanisms of drug and chemical placental transfer and metabolism. All the currently available methodologies have specific strengths and limitations, highlighting the strong demand to utilize an efficient combination of them to obtain reliable evidence concerning drug and chemical transfer and metabolism across the placental barrier. To derive the most consistent and safe evidence, in vitro studies, ex vivo perfusion methods, and in vivo animal and human studies can be applied together with the final aim to minimize potential fetotoxicity effects. Conclusions: Research is being increasingly carried out to obtain an accurate and safe evaluation of drug and chemical transport and metabolism across the placental barrier, applying a combination of advanced techniques to avoid potential fetotoxic effects. The improvement of the currently available techniques and the development of novel experimental protocols and methodologies are of major importance to protect both the mother and the fetus from xenobiotic exposure, as well as to minimize potential fetotoxicity effects.

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Section: Resultsmentioning

confidence: 99%

Fetus Exposure to Drugs and Chemicals: A Holistic Overview on the Assessment of Their Transport and Metabolism across the Human Placental Barrier

Kotta-Loizou,

Pritsa,

Antasouras

et al. 2024

Diseases

View full text Add to dashboard Cite

show abstract

“…In order to determine the transplacental transfer ratio into the conceptus, our laboratory has made efforts in conventional sampling techniques [ 15 , 16 ], as well as microdialysis [ [17] , [18] , [19] , [20] ]. Microdialysis is a technique that uses probes with semipermeable membrane to sample endogenous and exogenous substances [ [21] , [22] , [23] ].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic analysis of placental transfer of ritonavir as a component of paxlovid using microdialysis in pregnant rats

Sun,

Lee,

Yang

et al. 2024

Heliyon

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Water-insoluble dietary fiber from walnut relieves constipation through Limosilactobacillus reuteri-mediated serotonergic synapse and neuroactive ligand-receptor pathways

Yang,

Gao,

Lin

et al. 2024

International Journal of Biological Macromolecules

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Pharmacokinetics and transplacental transfer of codeine and codeine metabolites from Papaver somniferum L.

Cited by 4 publications

References 39 publications

Fetus Exposure to Drugs and Chemicals: A Holistic Overview on the Assessment of Their Transport and Metabolism across the Human Placental Barrier

Fetus Exposure to Drugs and Chemicals: A Holistic Overview on the Assessment of Their Transport and Metabolism across the Human Placental Barrier

Pharmacokinetic analysis of placental transfer of ritonavir as a component of paxlovid using microdialysis in pregnant rats

Water-insoluble dietary fiber from walnut relieves constipation through Limosilactobacillus reuteri-mediated serotonergic synapse and neuroactive ligand-receptor pathways

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