Pharmacokinetics, bioavailability and withdrawal period of antibiotic oxytetracycline in catfish Pangasianodon hypophthalmus

Manna, Sanjib Kumar; Das, Nilemesh; Sarkar, Dhruba Jyoti; Bera, Asit Kumar; Baitha, Raju; Nag, Subir; Das, Basanta Kumar; Kumar, Ashok; Rajisha, Ravindran; Krishna, N. Hari; Patil, Prasanna Kumar

doi:10.1016/j.etap.2021.103778

Cited by 10 publications

(4 citation statements)

References 46 publications

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“…The reason why the tissue concentration of OTC is high in plasma may be due to its lipophilic structure and partially low binding to plasma proteins. Similar to our research, the maximum concentration was found in the liver of fish in other studies [10,[40][41][42]. The kidney in mammals and birds and the liver in fish play important roles in the excretion of OTC [32,43,44].…”

Section: Introductionsupporting

confidence: 91%

“…OTC has a bacteriostatic effect and prevents bacterial protein synthesis by binding to the 30S ribosomal subunit of susceptible bacteria and blocking the mRNA binding of tRNA [9]. OTC is the first-choice antibiotic in the treatment of septicemia, furunculosis, enteric red mouth disease, rainbow trout fry syndrome, and vibriosis diseases in fish and is used orally at a dose of 60-100 mg/kg every 24 h for 5-10 days [4,9,10]. The MRL of OTC for muscle+skin in fish was 100 µg/kg in the European Union (EU) and 200 µg/kg in China [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics, Tissue Residues, and Withdrawal Times of Oxytetracycline in Rainbow Trout (Oncorhynchus mykiss) after Single- and Multiple-Dose Oral Administration

Corum,

Durna Corum,

Terzi

et al. 2023

Animals

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The aim of this study was to compare the pharmacokinetics of oxytetracycline (OTC) following single- (60 mg/kg) and multiple-dose oral administrations (60 mg/kg, every 24 h for 7 days) in rainbow trout. It also aimed to determine bioavailability after a single dose and tissue residues and withdrawal times after multiple doses. This study was carried out on 420 rainbow trout at 9 ± 0.8 °C. This study was carried out in two stages: single-dose (intravascular and oral) and multiple-dose treatment. The OTC concentrations in plasma and tissues were measured by high-performance liquid chromatography and analyzed by a non-compartmental method. The withdrawal time (WT) was estimated using the WT 1.4 software. OTC exhibited a long terminal elimination half-life (t1/2ʎz) after IV and oral administration. The oral bioavailability of OTC was very low (2.80%). In multiple-dose treatment, t1/2ʎz, the area under the plasma concentration–time curve and peak plasma concentration increased significantly after the last day compared to the first day. OTC showed strong accumulation after multiple doses with a value of 5.33. OTC concentrations were obtained in the order liver > kidney > muscle+skin > plasma. At 9 ± 0.8 °C, the WT calculated for muscle+skin was 56 days for Europe and 50 days for China, respectively. The t1/2ʎz (68.94 h) and time (68 h) above the 1 µg/mL MIC following a single OTC dose may support the extension of the 24 h dosing interval following multiple dosing. However, further studies are required to determine the optimal dosage regimen in multiple-dose OTC treatment in the treatment of infections caused by susceptible pathogens.

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Section: Introductionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics, Tissue Residues, and Withdrawal Times of Oxytetracycline in Rainbow Trout (Oncorhynchus mykiss) after Single- and Multiple-Dose Oral Administration

Corum,

Durna Corum,

Terzi

et al. 2023

Animals

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“…74,93 Dose and regimen optimization, clinical outcomes, pharmacokinetics and pharmacodynamics, withdrawal period and antibiotic degradation have been extensively studied. 94 Safety, tissue distribution, depletion and withdrawal period of OTC have been reported extensively in Oreochromis spp., 95,96 Gambusia holbrooki, 97 Oncorhynchus mykiss, 98 Oreochromis niloticus, [99][100][101] Trachinotus blochii, 102 Pangasianodon hypophthalmus, 103 Labeo rohita, 104 Dicentrarchus labrax, 105 Sparus aurata 105,106 and P. vannamei etc. 107 OTC is known to rapidly degrade in aquaculture environments through photo and thermo-degradation.…”

Section: Chemicals Biologicals and Vmps Used In Indian Aquaculturementioning

confidence: 99%

Usage pattern of chemicals, biologicals and veterinary medicinal products in Indian aquaculture

Patil

Mishra

Pradhan

et al. 2022

Reviews in Aquaculture

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The use of chemicals, biologicals and veterinary medicinal products (VMPs) helps in healthy and sustainable fish production. Information on the use of these products is essential for assessing farming practices, potential human health and environmental risks. A questionnaire‐based nationwide survey covering aquaculture farms (n = 2936) producing carps, tilapia, pangasius and rainbow trout in freshwater and shrimp in brackishwater estimated the use of 52 different types of inputs which included disinfectants (597 g t−1), probiotics (2.28 kg t−1), environmental modifiers (22.82 kg t−1), nutritional supplements (1.96 kg t−1), natural anti‐infective agents (293 g t−1), herbicide and piscicides (844 g t−1), antibiotics (2 mg PCU−1), antifungal (4 mg PCU−1), and antiparasitic (14 mg PCU−1) agents. The bulk of these inputs was used for soil and water quality improvement and had low environmental and human safety concerns. The multivariate analysis revealed significant variation in the frequency and quantity of compounds use among farm groups. Redundancy analysis revealed a significant association between the number of products used and stocking density. The survey also showed a considerable influence of education and farming experience on the usage pattern of aquaculture inputs. Results of the study indicated greater reliance of farmers on the use of disinfectants for biosecurity, nutritional supplements for enhanced growth and environmental modifiers for maintaining soil and water quality in culture systems. Though there was no use of restricted antibiotics and antiparasitic agents, the development and implementation of standard regulatory guidelines are essential for safe and effective use of inputs for sustainable aquaculture.

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“…Oxytetracycline concentration after last day administration, the thick black line represents maximum tolerance limit (MTL) of oxytetracycline 2 ppm in the muscle by FDA (FDA, 2022) Profil farmakokinetik oksitetrasiklin pada ikan lele ..... (Tatik Mufidah) dependent killing (Craig & Gudmundsson, 1996;Craig, 2007), sehingga lamanya waktu kadar obat bertahan di atas MIC sangat penting untuk kemanjuran terapi (Shergel et al, 2012). Manna et al (2022); Ali Abadi & Lees (2000); dan Stamm (1989) Terapi oksiterasiklin pada ikan uji yang diinfeksi dengan A. hydrophila menunjukkan bahwa pemberian oksitetrasiklin meningkatkan survival rate dengan withdrawal time 30 hari. Hal tersebut menghindarkan kerugian ekonomi akibat kematian ikan dan setelah melewati withdrawal time ikan aman untuk dikonsumsi.…”

Section: Hydrophila (Ah)]; (C) Liver Of Healty Fish; (D) the Liver Of...unclassified

PROFIL FARMAKOKINETIK OKSITETRASIKLIN PADA IKAN LELE, Clarias gariepinus DENGAN INFEKSI ARTIFISIAL Aeromonas hydrophila

Mufidah

Sukenda²,

Widanarni³

et al. 2022

Jurnal Riset Akuakultur

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Oksitetrasiklin banyak digunakan dalam manajemen terapeutik maupun preventif infeksi penyakit bakterial pada akuakultur. Konsentrasi obat yang tepat dalam tubuh penting untuk kemanjuran terapi tidak hanya ditentukan oleh dosis obat tetapi juga farmakokinetik obat yang dapat diketahui dari parameter farmakokinetiknya. Parameter farmakokinetik meliputi waktu paruh, kadar puncak, waktu puncak, volume distribusi, area di bawah kurva (AUC), eliminasi, dan distribusi obat baik dalam keadaan fisiologi maupun patologi. Penelitian ini bertujuan untuk mengetahui parameter farmakokinetik dan waktu henti obat (withdrawal time) oksitetrasiklin yang diberikan secara oral pada ikan lele yang diinfeksi dengan Aeromonas hydrophila. Kondisi patofisiologi yang memengaruhi mekanisme kerja obat akibat infeksi A. hydrophila diketahui dengan pengamatan histologi. Visualisasi keberadaan bakteri A. hydrophila pada organ ikan lele menggunakan imunohistokimia. Konsentrasi obat dalam plasma diukur dengan kromatografi cair kinerja tinggi (KCKT). Studi ini mengungkapkan farmakokinetik obat dan waktu henti obat yang berbeda pada ikan sehat/tidak diinfeksi dan sakit/diinfeksi A. hydrophila. Kadar oksitetrasiklin pada plasma ikan sehat 229,00 mg/L dan ikan terinfeksi A. hydrophila 99,16 mg/L yang dicapai pada 1,5 jam setelah pemberian. Area di bawah kurva yang menggambarkan jumlah obat dalam sirkulasi sistemik pada ikan sehat sebesar 943,6 mg.h/L; sedangkan pada ikan sakit sebesar 814,05 mg.h/L. Area di bawah kurva untuk waktu tak terhingga pada ikan sehat 1.586,42 mg.h/L dan 1.516,47 mg.h/L. Waktu paruh pada ikan sehat 9,36 jam dan ikan tidak terinfeksi 9,65 jam. Pengamatan histologi pada organ yang berperan dalam mekanisme obat yaitu hati, ginjal, dan usus mengalami kelainan patologi. Visualisasi A. hydrophila dengan imunohistokimia menunjukkan bakteri banyak terlokasilasi dalam lumen pembuluh darah. Waktu henti obat setelah 10 hari pemberian dengan dosis terapeutik pada ikan sehat yaitu 20 hari pada ikan sehat dan 30 hari pada ikan sakit. Sebagai kesimpulan kadar oksitetrasiklin pada plasma ikan sehat lebih besar daripada ikan sakit, dan diikuti dengan perbedaan pada parameter farmakokinetik lainnya dan waktu henti obat yang lebih lama pada ikan sakit.Oxytetracycline is widely used in the therapeutic and preventive management of bacterial infections in aquaculture. The accurate concentration of drug in the body is important for therapeutic efficacy not only determined by the dose but also the pharmacokinetics of the drug which can be known from its pharmacokinetic parameters. Pharmacokinetic parameters include half-life, maximum concentration, time of maximum concretation, volume distribution, area under the curve (AUC), elimination, and distribution of the drug in both physiological and pathological conditions. This study aimed to determine the pharmacokinetic parameters and withdrawal time of oxytetracycline administered orally to uninfected and infected catfish infected with Aeromonas hydrophila. Pathophysiological conditions that affect the drug’s mechanism of action due to infection with A. hydrophila by histological observations. Visualization of A. hydrophila bacteria in catfish organs using immunohistochemical assay. The plasma drug concentration was measured by high performance liquid chromatography (HPLC). This study revealed different drug pharmacokinetics parameters and withdrawl time of uninfected and infected fish with A. hydrophila. Oxytetracycline levels in the plasma of the uninfected fish were 229.00 mg/L and 99.16 mg/L in infected fish which were reached 1.5 hours after administration. The area under the curve that describes the amount of drug in the systemic circulation of uninfected fish is 943.6 mg.h/L, while in infected fish is 814.05 mg.h/L. The area under the curve for infinitive depicting the amount of drug in the systemic circulation in uninfected fish was 943.6 mg.h/L, while in infected fish was 814.05 mg.h/L. Histological observations on the organs that play a role in the drug mechanism, to be specific on the liver, kidney, and intestine showed pathological abnormalities. Visualization of A. hydrophila by immunohistochemistry showed that bacteria were located in the lumen of blood vessels. The withdrawal time of oxytetracycline after 10 days of administration in uninfected and infected fish were 20 and 30 days, repectively. In conclusion, plasma levels of oxytetracycline in uninfected fish were greater than in infected fish and were followed by differences in other pharmacokinetic parameters and longer drug withdrawal times in infected fish.

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Pharmacokinetics, bioavailability and withdrawal period of antibiotic oxytetracycline in catfish Pangasianodon hypophthalmus

Cited by 10 publications

References 46 publications

Pharmacokinetics, Tissue Residues, and Withdrawal Times of Oxytetracycline in Rainbow Trout (Oncorhynchus mykiss) after Single- and Multiple-Dose Oral Administration

Pharmacokinetics, Tissue Residues, and Withdrawal Times of Oxytetracycline in Rainbow Trout (Oncorhynchus mykiss) after Single- and Multiple-Dose Oral Administration

Usage pattern of chemicals, biologicals and veterinary medicinal products in Indian aquaculture

PROFIL FARMAKOKINETIK OKSITETRASIKLIN PADA IKAN LELE, Clarias gariepinus DENGAN INFEKSI ARTIFISIAL Aeromonas hydrophila

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