2007
DOI: 10.1124/dmd.107.017863
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Pharmacokinetics, Disposition, and Metabolism of Bicifadine in the Mouse, Rat, and Monkey

Abstract: ABSTRACT:Bicifadine [DOV 220,075; (؎)-1-(4-methylphenyl)-3-azabicyclo[3.1.0]-hexane HCl)] is a non-narcotic analgesic that is effective in animal models of acute and chronic pain. In this study, the pharmacokinetics, disposition, and metabolism of bicifadine were determined in male and female mice, rats, and cynomolgus monkeys following single oral and i.v. doses. [ 14 C]Bicifadine was well absorbed in all three species. The oral bioavailability of bicifadine in mice and rats was 50 to 63% and 79 to 85%, respe… Show more

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Cited by 16 publications
(17 citation statements)
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“…A similar fragmentation mechanism was observed for bicifadine (m/z 105), M3 (m/z 135) (Fig. 7), and M2 (m/z 121) (Musick et al, 2008).…”
Section: Krieter Et Almentioning
confidence: 48%
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“…A similar fragmentation mechanism was observed for bicifadine (m/z 105), M3 (m/z 135) (Fig. 7), and M2 (m/z 121) (Musick et al, 2008).…”
Section: Krieter Et Almentioning
confidence: 48%
“…The concentration of M12 had declined by 4 h, whereas the concentration of bicifadine was minor. No acyl glucuronide conjugate of M3 was detected in human plasma as it was in mouse (Musick et al, 2008).…”
Section: When [mentioning
confidence: 99%
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