Pharmacokinetics, Metabolism, Distribution and Permeability of Nanomedicine

Ravindran, Selvan; Suthar, Jitendra Kumar; Rokade, Rutuja; Deshpande, Pooja; Singh, Pooja; Pratinidhi, Ashutosh; Khambadkhar, Rajeshree; Utekar, Srushti

doi:10.2174/1389200219666180305154119

Cited by 64 publications

(38 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nanoencapsulation of drugs and bioactive compounds with low solubility, volatility, or viscosity is an important tool to improve these characteristics and control the release profiles. In addition, nanoencapsulation can protect the molecule from premature degradation or loss of functionality, and improve the biopharmaceutical and pharmacokinetic properties, resulting in improved therapeutic efficacy (Ravindran et al, 2018;Yao, Mcclements, Xiao, 2015;Khan, Gurav, 2018;Amreddy et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Bovine serum albumin-based nanoparticles containing the flavonoid rutin produced by nano spray drying

Pedrozo

Antônio

Khalil

et al. 2020

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

Rutin is a flavonoid compound obtained from different vegetables and fruits; specifically, it is found in the seeds of buckwheat and in fruit peels, particularly citrus. It is also an important constituent of red wine. Rutin exhibits various biological properties including antiviral, vasoprotective, anti-inflammatory, and anticarcinogenic activities. However, its antioxidant activity is the most well studied. Despite the potential for in vitro applications, rutin presents low oral bioavailability that affects its biological activities. Nanoparticles composed of polymers, protein, or lipids are of great importance in the pharmaceutical and nutraceutical areas due to their physicochemical properties, which improve the pharmacokinetics of the drug which is loaded within. This study presents the production of bovine serum albumin (BSA) nanoparticles containing rutin by nano spray drying. Nanoparticles were characterized in terms of mean particle size, size distribution, morphology, zeta potential, and drug content; as well as their antioxidant activity. The optimized spray-drying conditions produced spherical particles with a mean size of 316 nm, zeta potential of −32 mV, and encapsulation efficiency around 32%. Moreover, when antioxidant activity toward the ABTS + radical was assayed, nanoencapsulation increased the IC 50 of rutin by 2-fold. The nano spray-drying process proved to be suitable for the production of rutin-loaded BSA nanoparticles with potential antioxidant activity.

show abstract

Section: Introductionmentioning

confidence: 99%

Bovine serum albumin-based nanoparticles containing the flavonoid rutin produced by nano spray drying

Pedrozo

Antônio

Khalil

et al. 2020

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

show abstract

“…Delivery by nanocarriers generally may have varied therapeutic advantages. These advantages include, among others, an increased half-life, extended circulation time, enhanced mean residence time, and improved pharmacokinetic clearance of these agents from the body (Ravindran et al, 2018). Currently, many nanosized delivery systems intended for oral administration of phytotherapeutics have reached the clinical trial stage and are increasingly applied in clinical practice (Hajialyani et al, 2018).…”

Section: Therapeutic Nanodelivery Systemsmentioning

confidence: 99%

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Vaiserman

Koliada

Zayachkivska

et al. 2020

Front. Bioeng. Biotechnol.

147

View full text Add to dashboard Cite

The aging process is known to be associated with heightened oxidative stress and related systemic inflammation. Therefore, antioxidant supplementation is regarded as a promising strategy to combat aging and associated pathological conditions. Food-grade antioxidants from plant-derived extracts are the most common ingredients of these supplements. Phyto-bioactive compounds such as curcumin, resveratrol, catechins, quercetin are among the most commonly applied natural compounds used as potential modulators of the free radical-induced cellular damages. The therapeutic potential of these compounds is, however, restricted by their low bioavailability related to poor solubility, stability, and absorbance in gastrointestinal tract. Recently, novel nanotechnology-based systems were developed for therapeutic delivery of natural antioxidants with improved bioavailability and, consequently, efficacy in clinical practice. Such systems have provided many benefits in preclinical research over the conventional preparations, including superior solubility and stability, extended half-life, improved epithelium permeability and bioavailability, enhanced tissue targeting, and minimized side effects. The present review summarizes recent developments in nanodelivery of natural antioxidants and its application to combat pathological conditions associated with oxidative stress.

show abstract

“…86 Nanoparticles presented in solid or liquid forms also penetrate the barriers as well as associated physical, biological, and chemical processes of the tract,consequently, altering and transforming their pharmacological and toxicological properties. 87 Importantly, particle size is an essential factor,the smaller the particle size, the more effective its disease curative effects. As a result, NPs synthesized drugs have higher penetration, proper absorption, more extensive distribution, better metabolism, and greater bioavailability compared to drugs of the same size.…”

Section: Pharmacokine Tic S Of Nanoparti Cle S In Rel Ati On To Te S Ticul Ar Tissue and B Lood-te S Tis Barriermentioning

confidence: 99%

Nanoparticle delivery system, highly active antiretroviral therapy, and testicular morphology: The role of stereology

Naidu

Olojede

Lawal

et al. 2021

Pharmacology Res & Perspec

View full text Add to dashboard Cite

The existence of a protective "sanctuary site" in the testis, which limits drug concentration or sequestration, has been suggested. [1][2][3] This sanctuary site is typified by the testis, an essential compartmentalized reproductive organ within the scrotum. It is encapsulated in the outermost to the innermost thick layers of connective tissue capsules, tunica vaginalis, tunica albuginea, and tunica vasculosa. 4 Septa from the tunica albuginea partition the testis into different lobules.Each of these lobules contains seminiferous tubules that are approximately 200 μm in diameter, with a total length of ~600 m that contributes to about 60 percent of the total volume of the testis. 5,6

show abstract

Pharmacokinetics, Metabolism, Distribution and Permeability of Nanomedicine

Cited by 64 publications

References 0 publications

Bovine serum albumin-based nanoparticles containing the flavonoid rutin produced by nano spray drying

Bovine serum albumin-based nanoparticles containing the flavonoid rutin produced by nano spray drying

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Nanoparticle delivery system, highly active antiretroviral therapy, and testicular morphology: The role of stereology

Contact Info

Product

Resources

About