Pharmacokinetics of 111In-labelled monoclonal antibody ZCE-025 and fragments in tumour-bearing mice

Small-Animal Spect Imaging

“…It is possible to get an idea of the potential impact of high-resolution detectors on SPECT imaging via the well-known, basic equations for planar pinhole imaging [Anger, 1967]. From the basic pinhole imaging scheme depicted in Fig.…”

“…To study the influence of these scattering events within the imaging system, a simulation was done using the EGSnrc Monte Carlo software [Kawrakow, 2000]. Given that a 27 keV photon loses a maximum of 2.6 keV in a Compton scatter, energy windowing would be of little use in reducing the contribution of these scattered photons.…”

“…111 In is well suited for radioimmunoscintigraphy because it binds easily to proteins and has a long half-life that matches the uptake and washout characteristics of most radiolabeled antibodies [Koziol, et al 1995]. Small-animal SPECT can be performed with a wide spectrum of radiopharmaceuticals, including those labeled with 125 I, 99m Tc, and 111 In.…”