2019
DOI: 10.1556/1326.2018.00429
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Pharmacokinetics of 8-O-acetylharpagide in mouse blood by UPLC–MS/MS

Abstract: Acetylharpagide is the main active component of the herb Ajuga decumbens, which possesses anti-tumor, antivirus, and anti-inflammation properties. In this study, ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was used to measure the concentration of 8-O-acetylharpagide in mouse blood, with subsequent investigation of the pharmacokinetics of the drug after intravenous or oral administration. Shanzhiside methyl ester was used as an internal standard, and the acetonitrile precipitat… Show more

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