Pharmacokinetics of a New Analgesic on the Basis of Hexaazaisowurtzitane Derivative

Bryushinina, O. S.; Yanovskaya, E. A.; Abdrashitova, N. Yu.; Zyuz’kova, Yu. G.; Frelikh, Galina A.; Lopatina, K. A.; Зуева, Е. П.; Крылова, С. Г.; Kulagina, D. A.; Sysolyatin, S. V.; Удут, В. В.

doi:10.1007/s10517-021-05085-8

Cited by 2 publications

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“…Compound 10a was also evaluated for pharmacokinetics, relative bioavailability, biotransformation, distribution across the organs and tissues, and excreted capsulated dosage form [44]. The agent was observed to be rapidly absorbed from the digestive tract, actively distributed throughout tissues and organs in rats, and exhibited a large distribution volume within the organism.…”

Section: Analgesic Activity Of Hexaazaisowurtzitane Derivativesmentioning

confidence: 99%

Biological Activity of Hexaazaisowurtzitane Derivatives

Kulagina,

Sysolyatin,

Krylova

et al. 2023

Molecules

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Biologically active compounds of natural or synthetic origin have a complex structure and generally contain various structural groups among which polycyclic cage amines are found. Hexaazaisowurtzitanes are representatives of these amines and studies on their biological activity began less than two decades ago, starting with research on the environmental impact of CL-20. This research helped to evaluate the risks of potential pollution in the habitat environments of living organisms and determine whether the chemical compounds in question could be utilized in pesticides, herbicides, fungicides, or medicinal drugs. The nomenclature of hexaazaisowurtzitane compounds has recently been expanded significantly, and some of them have demonstrated promise in the design of medicinal drugs. This paper review studies the pharmacological activity of the acyl derivatives of hexaazaisowurtzitane. Most of the compounds have been found to possess a high analgesic activity, providing a solution to the pressing issue of pain management in current pharmacology. Analgesic drugs currently used in the clinical practice do not meet all of the efficacy and safety requirements (gastro-, nephro-, hepato-, haematotoxicity, etc.). The material presented in the seven sections of this paper highlights information about hexaazaisowurtzitane derivatives. Furthermore, they have been observed to exhibit anti-inflammatory, anticonvulsant, antihypoxic, and antimetastatic activities, which render them highly promising for evaluation in various fields of medicinal practice.

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Section: Analgesic Activity Of Hexaazaisowurtzitane Derivativesmentioning

confidence: 99%