Pharmacokinetics of a tri-glucoconjugated 5,10,15-(meta)-trihydroxyphenyl-20-phenyl porphyrin photosensitizer for PDT. A single dose study in the rat

Desroches, Marie-Catherine; Bautista-Sanchez, Antonia; Lamotte, C.; Labeque, Bella; Auchère, Daniel; Farinotti, Robert; Maillard, Philippe; Grierson, David S.; Prognon, Patrice; Kasselouri, Athéna

doi:10.1016/j.jphotobiol.2006.03.008

Cited by 21 publications

(20 citation statements)

References 27 publications

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“…Clearance is also much more rapid, after 48 h all PS was eliminated from all organs. This indicates significant potential compared to Foscan [69].…”

Section: Glycoporphyrinsmentioning

confidence: 90%

mTHPC – A drug on its way from second to third generation photosensitizer?

Senge

2012

Photodiagnosis and Photodynamic Therapy

111

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“…Clearance is also much more rapid, after 48 h all PS was eliminated from all organs. This indicates significant potential compared to Foscan [69].…”

Section: Glycoporphyrinsmentioning

confidence: 90%

mTHPC – A drug on its way from second to third generation photosensitizer?

Senge

2012

Photodiagnosis and Photodynamic Therapy

111

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“…The related porphyrin compound 59, 5,10,15-tris(meta-O-β-Dglucosyloxyphenyl)-20-phenylporphyrin, was used for an in vivo study in healthy rats. 56 In order to establish the pharmacokinetics of this class of compounds, three different drug doses of 59 were administered (0.25, 0.5 and 1 mg.kg -1 ), and compared to mTHPC at 0.3 mg.kg -1 . The conjugate 59 was cleared more rapidly from the organism compared to mTHPC, and its mean residence time was 5 h compared to mTHPC, which had a residence time of 20 h with no metabolite of either PS identified.…”

Section: (A) O-glycosylated Porphyrins and Chlorinsmentioning

confidence: 99%

“…This work was supported by Science Foundation Ireland (IvP 13/IA/1894) and the Egyptian Cultural and Educational Bureau (Channel 56 …”

Section: Acknowledgementsmentioning

confidence: 99%

Current Developments in Using MESO-(TETRA) Substituted Porphyrins for PDT

Shaker¹,

Sweed²,

Moylan³

et al. 2016

Handbook of Photodynamic Therapy

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“…mTHPC (0.3 mg/kg) was used as a control [260,360] . The glycoporphyrin was cleared three times faster from the animals than mTHPC with mean residence times of 5 and 20 h, respectively.…”

Section: In Vivo Studiesmentioning

confidence: 99%

Chemical Synthesis and Medicinal Applications of Glycoporphyrins

Moylan¹,

Scanlan²,

Senge

2015

CMC

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Abstract:This review presents an in-depth overview of the modification of porphyrins with bioconjugates and their applications in medicine today. Porphyrin bioconjugates ranging from nucleotides to steroids are under active scrutiny. However, carbohydrates have been at the forefront of such research in recent years and offer significant potential. This is attributed to their own selectivity to lectins on the surface of cancer cells and their influence on the amphiphilicity of the porphyrin macrocycle. These characteristics and the tendency of porphyrin photosensitizers to accumulate in tumor tissues make glycoporphyrins promising candidates for use as photosensitizers. Thus, a detailed overview of the synthesis and biological evaluation of glycoporphyrins is given with a particular focus on their applications in photodynamic therapy and their future prospects as drug candidates have been reported.

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Pharmacokinetics of a tri-glucoconjugated 5,10,15-(meta)-trihydroxyphenyl-20-phenyl porphyrin photosensitizer for PDT. A single dose study in the rat

Cited by 21 publications

References 27 publications

mTHPC – A drug on its way from second to third generation photosensitizer?

mTHPC – A drug on its way from second to third generation photosensitizer?

Current Developments in Using MESO-(TETRA) Substituted Porphyrins for PDT

Chemical Synthesis and Medicinal Applications of Glycoporphyrins

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