Pharmacokinetics of antibiotics for pleural infection

Lau, Estee P. M.; Sidhu, Calvinjit; Popowicz, Natalia; Lee, Y C Gary

doi:10.1080/17476348.2022.2147508

Cited by 3 publications

(2 citation statements)

References 82 publications

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“…In 1987, Shohet demonstrated that gentamicin had diminished efficacy in pleural infection, leading to reduced aminoglycoside use for pleural infection [7]. Given stark differences in conclusions compared to human pharmacokinetic studies, results from animal models should be interpreted with caution [2].…”

Section: Discussionmentioning

confidence: 99%

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Antibiotic pharmacokinetics in infected pleural effusions

Arnold,

Read,

Waddington

et al. 2023

Preprint

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Pleural infection is usually treated with empirical broad-spectrum antibiotics but limited data exists around their penetrance into the infected pleural space. We performed a pharmacokinetic study analysing the concentration of 5 intravenous antibiotics across 146 separate timepoints in 35 patients (amoxicillin, metronidazole, piperacillin-tazobactam, clindamycin and cotrimoxazole). All antibiotics tested, apart from co-trimoxazole, reach pleural fluid levels equivalent to levels within blood, and well above the relevant minimum inhibitory concentrations. The results demonstrate that concerns around the penetration of commonly used antibiotics, apart from co-trimoxazole, into the infected pleural space are unfounded.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Pleural infection is a serious clinical condition with a mortality of up to 15%[1]. Patients spend extended periods in hospital for pleural fluid drainage and intravenous antibiotic administration[1, 2]. There has been concern around the ability of antibiotics to reach therapeutic levels at the site of infection[2].…”

Section: Introductionmentioning

confidence: 99%

Antibiotic pharmacokinetics in infected pleural effusions

Arnold,

Read,

Waddington

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Pleural penetration of amoxicillin and metronidazole during pleural infection: An ambispective cohort study

Luque-Paz,

Verdier,

Lefèvre

et al. 2023

International Journal of Antimicrobial Agents

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Antibiotic pharmacokinetics in infected pleural effusions

Arnold,

Read,

Waddington

et al. 2024

Thorax

View full text Add to dashboard Cite

Pleural infection is usually treated with empirical broad-spectrum antibiotics, but limited data exist on their penetrance into the infected pleural space. We performed a pharmacokinetic study analysing the concentration of five intravenous antibiotics across 146 separate time points in 35 patients (amoxicillin, metronidazole, piperacillin-tazobactam, clindamycin and cotrimoxazole). All antibiotics tested, apart from co-trimoxazole, reach pleural fluid levels equivalent to levels within the blood and well above the relevant minimum inhibitory concentrations. The results demonstrate that concerns about the penetration of commonly used antibiotics, apart from co-trimoxazole, into the infected pleural space are unfounded.

show abstract

Pharmacokinetics of antibiotics for pleural infection

Cited by 3 publications

References 82 publications

Antibiotic pharmacokinetics in infected pleural effusions

Antibiotic pharmacokinetics in infected pleural effusions

Pleural penetration of amoxicillin and metronidazole during pleural infection: An ambispective cohort study

Antibiotic pharmacokinetics in infected pleural effusions

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