2014
DOI: 10.4269/ajtmh.13-0283
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Pharmacokinetics of Artesunate Alone and in Combination with Sulfadoxine/Pyrimethamine in Healthy Sudanese Volunteers

Abstract: Abstract. Artesunate (AS) in combination with sulfadoxine/pyrimethamine (SP) is the first-line therapy for management of uncomplicated Plasmodium falciparum malaria in Sudan. The objective of this study was to assess the potential impact of SP on the pharmacokinetics of AS and its active metabolite, dihydroartemisinin (DHA), in healthy adults. A single-dose, randomized, open-label, crossover study design with a washout period of three weeks was performed with 16 volunteers. After oral administration of AS alon… Show more

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Cited by 10 publications
(6 citation statements)
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“…One alternative regimen constitutes the use of a highly efficacious artemisinine (AS) derivative in association with AQ. Artesunate is a soluble derivative quickly adsorbed orally, the highest concentration in blood is achieved 1 h following an oral intake and the half-life is between 20 and 72 min ( Orrell et al, 2008 ; Saunders et al, 2012 ; Matar et al, 2014 ). AS pharmacokinetics parameters are similar when AS is given alone and when AS is combined with AQ ( Orrell et al, 2008 ).…”
Section: Introductionmentioning
confidence: 99%
“…One alternative regimen constitutes the use of a highly efficacious artemisinine (AS) derivative in association with AQ. Artesunate is a soluble derivative quickly adsorbed orally, the highest concentration in blood is achieved 1 h following an oral intake and the half-life is between 20 and 72 min ( Orrell et al, 2008 ; Saunders et al, 2012 ; Matar et al, 2014 ). AS pharmacokinetics parameters are similar when AS is given alone and when AS is combined with AQ ( Orrell et al, 2008 ).…”
Section: Introductionmentioning
confidence: 99%
“…When animals reached parasitaemia of 50-60% the first group was administered AAN as single dose (35 mg/kg equivalent amount of artemether) intravenous injection. Artemether free drug being insoluble in water its solution was prepared by dissolving it in non clinical hydroaholic vehicle (ATM) [35] and administered intravenously to the second group while third group acted as control. At stipulated time interval of 10min, 30min, 1, 2, 4, 8, 10, and 24h, the animals were exposed to inhalation of anaesthetic ether and blood samples were withdrawn using retro-orbital puncture.…”
Section: Pharmacokinetics In P Berghei Infected Micementioning
confidence: 99%
“…Nonetheless, sulfadoxine has been linked to serious to fatal cases of erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, and serum sickness syndromes. Pyrimethamine, first formulated in the 1950s, prevents the conversion of folic acid and dihydrofolic acid to the active tetrahydrofolate coenzyme form, which is required for amino acid and nucleic acid synthesis [91]. This combination is recommended for the prevention and treatment of P. falciparum chloroquine resistance and can be used in conjunction with quinine.…”
Section: Sulfadoxine and Pyrimethaminementioning
confidence: 99%