Abstract:The pharmacokinetics of aspirin (ASA) has been studied in elderly Indians (greater than 60 y) of either sex, composing, apparently healthy subjects controlled hypertensives and NIDDM diabetics, in comparison with healthy young subjects. Serum salicylate levels were estimated a 0, 0.5, 1, 2, 4 & 8 h after ASA. The pharmacokinetics of serum salicylate were not changed in elderly subjects as compared to the young after the first dose or after one week of ASA therapy, although greater variability was observed in t… Show more
“…However, most pharmacokinetic studies of aspirin have failed to demonstrate any significant age-related changes (Dhasmana et al 1990;Montgomery & Sitar 1981;Roberts et al 1983). In a few instances there have been reports of minor abnormalities, but their clinical significance is probably restricted to elderly people with significant concomitant renal disease or reduced serum albumin (Cuny et al 1979).…”
Section: Pharmacokinetics In the Elderlymentioning
“…However, most pharmacokinetic studies of aspirin have failed to demonstrate any significant age-related changes (Dhasmana et al 1990;Montgomery & Sitar 1981;Roberts et al 1983). In a few instances there have been reports of minor abnormalities, but their clinical significance is probably restricted to elderly people with significant concomitant renal disease or reduced serum albumin (Cuny et al 1979).…”
Section: Pharmacokinetics In the Elderlymentioning
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.