Pharmacokinetics of carumonam (AMA-1080) in patients with impaired renal function and in those undergoing hemodialysis

Konishi, Konosuke; Suzuki, Hiromichi; Saruta, Takao; Deguchi, Nobuhiro; Fugono, Takeshi

doi:10.1128/aac.35.6.1048

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…In this study, the RDD was calculated to be 56.12 ± 8.11%. With other β‐lactam antibiotics, the RDD ranged from 46–53% for hemodialysis for 4–6 h (12–19). The RDDs for imipenem and meropenem in particular, which are carbapenem antibiotics like doripenem, were reported to be 54.8% (20) and 52% (21), respectively.…”

Section: Discussionmentioning

confidence: 99%

Removal of Doripenem During Hemodialysis and the Optimum Dosing Regimen for Patients Undergoing Hemodialysis

et al. 2011

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The removal of doripenem by hemodialysis was studied in six hemodialysis patients. Following an intravenous drip infusion of 0.5 g of doripenem, plasma concentrations of the drug were measured. The decrease in drug concentrations in plasma was observed during various periods of non-hemodialysis, and hemodialysis accelerated the elimination of doripenem. For example, the calculated mean half-life during hemodialysis was significantly shorter than that during non-hemodialysis periods (P = 0.002). The calculated pharmacokinetic parameters indicated that the mean rate of decrease in plasma concentration due to hemodialysis alone was 56.12 ± 8.11%. Upon obtaining these results and several pharmacokinetic parameters, we attempted to optimize the dosing regimen of doripenem for hemodialysis patients. We recommend the use of 0.25 g of doripenem once a day in patients infected with viable bacteria, and in patients who are infected with Pseudomonas aeruginosa, 0.5 g twice a day on the first day of administration, followed by 0.5 g once a day.

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Section: Discussionmentioning

confidence: 99%