Pharmacokinetics of cefquinome in rainbow trout (<i>Oncorhynchus mykiss</i>) after intravascular, intraperitoneal, and oral administrations

Çorum, Duygu Durna; Çorum, Orhan; Terzi̇, Ertuğrul; Coşkun, Devran; Bi̇len, Soner; Gül, Çetin; Üney, Kamil

doi:10.1111/jvp.13091

Cited by 9 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tolfenamic acid concentrations were determined for six fish at each sampling time and averaged. Pharmacokinetic data of tolfenamic acid were calculated from the average plasma concentration at sampling times, as documented in previous studies (Corum et al., 2023 ; Durna Corum et al., 2022 ). The area under the concentration (AUC) versus time curve, AUC extrapolated from t last to ∞ in % of the total AUC (AUC extrap %), volume of distribution at steady state ( V dss ), total body clearance (Cl T ), terminal elimination half‐life ( t 1/2λz ), mean residence time (MRT), mean absorption time (MAT = MRT IM,oral − MRT IV ) and bioavailability ( F = AUC IM,oral × 100/AUC IV ) were calculated.…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetics, bioavailability and plasma protein binding of tolfenamic acid in rainbow trout (Oncorhynchus mykiss)

Corum,

Durna Corum,

Marin

et al. 2024

Veterinary Medicine & Sci

Self Cite

View full text Add to dashboard Cite

BackgroundAlthough research on the mechanism and control of pain and inflammation in fish has increased in recent years, the use of analgesic drugs is limited due to the lack of pharmacological information about analgesic drugs. Tolfenamic acid is a non‐steroidal anti‐inflammatory drug and can be used in fish due to its low side effect profile and superior pharmacokinetic properties.ObjectivesThe pharmacokinetics, bioavailability and plasma protein binding of tolfenamic acid were investigated following single intravascular (IV), intramuscular (IM) and oral administration of 2 mg/kg in rainbow trout at 13 ± 0.5°C.MethodsThe experiment was carried out on a total of 234 rainbow trout (Oncorhynchus mykiss). Tolfenamic acid was administered to fish via IV, IM and oral route at a dose of 2 mg/kg. Blood samples were taken at 13 different sampling times until the 72 h after drug administration. The plasma concentrations of tolfenamic acid were quantified using high pressure liquid chromatography–ultraviolet (UV) and pharmacokinetic parameters were assessed using non‐compartmental analysis.ResultsThe elimination half‐life (t1/2ʎz) of tolfenamic acid for IV, IM and oral routes was 3.47, 6.75 and 9.19 h, respectively. For the IV route, the volume of distribution at a steady state and total body clearance of tolfenamic acid were 0.09 L/kg and 0.03 L/h/kg, respectively. The peak plasma concentration and bioavailability for IM and oral administration were 8.82 and 1.24 µg/mL, and 78.45% and 21.48%, respectively. The mean plasma protein binding ratio of tolfenamic acid in rainbow trout was 99.48% and was not concentration dependent.ConclusionsWhile IM route, which exhibits both the high plasma concentration and bioavailability, can be used in rainbow trout, oral route is not recommended due to low plasma concentration and bioavailability. However, there is a need to demonstrate the pharmacodynamic activity of tolfenamic acid in rainbow trout.

show abstract

Section: Methodsmentioning

confidence: 99%

Pharmacokinetics, bioavailability and plasma protein binding of tolfenamic acid in rainbow trout (Oncorhynchus mykiss)

Corum,

Durna Corum,

Marin

et al. 2024

Veterinary Medicine & Sci

Self Cite

View full text Add to dashboard Cite

show abstract

“…Using the WinNonlin 6.1.0.173 software program (Pharsight Corporation, Scientific Consulting Inc., Sunnyvale, NC, USA), the plasma concentration–time curves of doxycycline were plotted. After oral administration, pharmacokinetic parameters were determined via non-compartmental analysis using mean plasma concentrations of doxycycline collected at each sampling time [ 25 , 26 , 27 ]. After the doxycycline administration, apparent volume of distribution (V darea /F), total body clearance (CL/F, area under the concentration–time curve (AUC), terminal elimination half-life (t 1/2ʎz ), AUC extrapolated from t last to ∞ in % of the total AUC (AUC extrap %), and mean residence time (MRT) were determined.…”

Section: Methodsmentioning

confidence: 99%

Effects of Temperature on the Pharmacokinetics, Tissue Residues, and Withdrawal Times of Doxycycline in Rainbow Trout (Oncorhynchus mykiss) following Oral Administration

Çorum

Üney

Terzi̇

et al. 2023

Veterinary Sciences

Self Cite

View full text Add to dashboard Cite

The purpose of this study was to compare the pharmacokinetics, tissue residues, and withdrawal times of doxycycline after oral administration in rainbow trout reared at 10 and 17 °C. Fish received a 20 mg/kg oral dose of doxycycline after a single or 5-day administration. Six rainbow trout were used at each sampling time point for plasma and tissue samples, including liver, kidney, and muscle and skin. The doxycycline concentration in the samples was determined using high-performance liquid chromatography with ultraviolet detector. The pharmacokinetic data were evaluated by non-compartmental kinetic analysis. The WT 1.4 software program was used to estimate the withdrawal times. The increase of temperature from 10 to 17 °C shortened the elimination half-life from 41.72 to 28.87 h, increased the area under the concentration–time curve from 173.23 to 240.96 h * μg/mL, and increased the peak plasma concentration from 3.48 to 5.50 μg/mL. At 10 and 17 °C, the doxycycline concentration was obtained in liver > kidney > plasma > muscle and skin. According to the MRL values stated for muscle and skin in Europe and China (100 μg/kg) and in Japan (50 μg/kg), the withdrawal times of doxycycline at 10 and 17 °C were 35 and 31 days, respectively, for Europe and China and 43 and 35 days, respectively, for Japan. Since temperature significantly affected pharmacokinetic behavior and withdrawal times of doxycycline in rainbow trout, temperature-dependent dosing regimens and withdrawal times of doxycycline might be necessary.

show abstract

“…Pharmacokinetic non-compartmental analysis of OTC concentration-time data was analyzed using the WinNonlin 6.1.0.173 software (Pharsight Corporation, Scientific Consulting Inc., Raleigh, NC, USA). Pharmacokinetic parameters of OTC were calculated from the mean plasma concentration values collected at each sampling time, as reported in previous studies [20,21]. The pharmacokinetic parameters calculated included the area under the plasma concentration-time curve (AUC), AUC extrapolated from tlast to ∞ in % of the total AUC (AUC extrap %), volume of distribution at steady state (V dss = Cl T × MRT), apparent volume of distribution (V darea ), total body clearance (Cl T = Dose/AUC), terminal elimination half-life (t 1/2…”

Section: Pharmacokinetic Analysismentioning

confidence: 99%

Pharmacokinetics, Tissue Residues, and Withdrawal Times of Oxytetracycline in Rainbow Trout (Oncorhynchus mykiss) after Single- and Multiple-Dose Oral Administration

Corum,

Durna Corum,

Terzi

et al. 2023

Animals

Self Cite

View full text Add to dashboard Cite

The aim of this study was to compare the pharmacokinetics of oxytetracycline (OTC) following single- (60 mg/kg) and multiple-dose oral administrations (60 mg/kg, every 24 h for 7 days) in rainbow trout. It also aimed to determine bioavailability after a single dose and tissue residues and withdrawal times after multiple doses. This study was carried out on 420 rainbow trout at 9 ± 0.8 °C. This study was carried out in two stages: single-dose (intravascular and oral) and multiple-dose treatment. The OTC concentrations in plasma and tissues were measured by high-performance liquid chromatography and analyzed by a non-compartmental method. The withdrawal time (WT) was estimated using the WT 1.4 software. OTC exhibited a long terminal elimination half-life (t1/2ʎz) after IV and oral administration. The oral bioavailability of OTC was very low (2.80%). In multiple-dose treatment, t1/2ʎz, the area under the plasma concentration–time curve and peak plasma concentration increased significantly after the last day compared to the first day. OTC showed strong accumulation after multiple doses with a value of 5.33. OTC concentrations were obtained in the order liver > kidney > muscle+skin > plasma. At 9 ± 0.8 °C, the WT calculated for muscle+skin was 56 days for Europe and 50 days for China, respectively. The t1/2ʎz (68.94 h) and time (68 h) above the 1 µg/mL MIC following a single OTC dose may support the extension of the 24 h dosing interval following multiple dosing. However, further studies are required to determine the optimal dosage regimen in multiple-dose OTC treatment in the treatment of infections caused by susceptible pathogens.

show abstract

Pharmacokinetics of cefquinome in rainbow trout (Oncorhynchus mykiss) after intravascular, intraperitoneal, and oral administrations

Cited by 9 publications

References 34 publications

Pharmacokinetics, bioavailability and plasma protein binding of tolfenamic acid in rainbow trout (Oncorhynchus mykiss)

Pharmacokinetics, bioavailability and plasma protein binding of tolfenamic acid in rainbow trout (Oncorhynchus mykiss)

Effects of Temperature on the Pharmacokinetics, Tissue Residues, and Withdrawal Times of Doxycycline in Rainbow Trout (Oncorhynchus mykiss) following Oral Administration

Pharmacokinetics, Tissue Residues, and Withdrawal Times of Oxytetracycline in Rainbow Trout (Oncorhynchus mykiss) after Single- and Multiple-Dose Oral Administration

Contact Info

Product

Resources

About