Pharmacokinetics of Da-125, a New Anthracycline, After Intravenous Administration to Uranyl Nitrate-Induced Acute Renal Failure Rats or Protein--Calorie Malnutrition Rats

Pharmacokinetics of drugs in rats with diabetes mellitus induced by alloxan or streptozocin: comparison with those in patients with type I diabetes mellitus

“…[160] In male Sprague-Dawley rats, M1 was metabolized to M3 via hepatic CYP1A1/2 and 2B1/2, and M2 was metabolized to M4 via CYP2B1/2. [161] After the intravenous administration of 15 mg/kg DA-125 to male Sprague-Dawley DMIA rats on the fourth day, the value of AUC 0-90 min of M4 became smaller than that of the controls, and the value of AUC 0-90 min of M3 went below the detection limit for both groups of rats. [162] Itraconazole In male Sprague-Dawley rats, both the metabolism of itraconazole and the formation of 7-hydoxyitraconazole were mediated via hepatic CYP3A1/2 (our unpublished data).…”

Effects of Cyclosporin on the Pharmacokinetics of Propranolol after Intravenous and Oral Administration to Control Rats and to Rats with Uranyl Nitrate-induced Acute Renal Failure

“…Induction of acute renal failure in rats by uranyl nitrate injection Uranyl nitrate (0Á5% in 0Á9% NaCl injectable solution; 1 mL kg À1 , equivalent to 5 mg kg À1 ), was injected once into the tail vein of a rat to induce acute renal failure (Kim et al 1996(Kim et al , 1998. The same volume of 0Á9% NaCl injectable solution was injected into control rats.…”

“…In the early morning on the ®fth day after injection of uranyl nitrate (rats with uranyl nitrate-induced acute renal failure) or 0Á9% NaCl injectable solution (control rats) the left femoral artery and the left femoral vein were cannulated with polyethylene tubing (PE 50; Clay Adams, Parsippany, NJ) under light ether anaesthesia (Kim et al 1996(Kim et al , 1998). The exposed areas were surgically sutured.…”

Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation

“…The pharmacokinetic changes of many drugs (either mainly excreted via renal excretion or by hepatic metabolism ) have been reported in rats with renal failure. The total area under the plasma concentration± time curve from time zero to time in® nity (AUC 0± ¢ ) was signi® cantly greater and time-averaged total body (CL), renal (CL R ), and}or nonrenal (CL NR ) clearances were signi® cantly slower after intravenous administration of the following drugs (or compounds) to rats with uranyl nitrate-induced renal failure : methotrexate (Park et al 1996), vancomycin (Engineer et al 1981), DA-1131, a new carbapenem (Kim et al 1998b), M1, an active component of a new anthracycline, DA-125 (Kim et al 1996), salicylic acid (Liu et al 1996), azosemide (Park et al 1998), diltiazem (Lee et al 1992), amiodarone (Fruncillo et al 1986), tetraethylammonium bromide and para-amino hippurate (Lin & Lin 1988). Those pharmacokinetic diOE erences were due mainly to diOE erences in the formation of conjugates or liver and}or kidney impairment in rats with uranyl nitrate-induced renal failure based on plasma and urine chemistry data and}or tissue microscopy (Kim et al 1998b and references therein).…”