Pharmacokinetics of danofloxacin after single oral and intravenous administration in non‐laying hens

Chen, Jun‐Cheng; Kang, Jijun; Zhang, Mei; Shao, Hao-Tian; Song, Zhe-Wen; Ma, Kaili; Yang, Fang; Yang, Fan

doi:10.1111/jvp.13098

Cited by 4 publications

(7 citation statements)

References 39 publications

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“…In a pharmacokinetic study, important parameters for assessing drug absorption rate include C max , T max , and t 1/2ka . In the current study, danofloxacin reached a peak concentration of 0.53 ± 0.19 µg/mL at 4 h after PO administration, with a t 1/2ka value of 2.37 ± 1.60 h. Under the same dosage (5 mg/kg) in different poultry species, the current C max was lower than that in Jing Hong hens (1.05 µg/mL) [ 12 ], Muscovy ducks (0.81 µg/mL) [ 18 ], and Bilgorajska geese (0.96 µg/mL) [ 11 ]. However, the peak concentration was similar to that found in Lingnan yellow broiler chickens (0.51 µg/mL) [ 19 ], Lohmann broiler chickens (0.47 µg/mL) [ 20 ], and Arbor Acres broilers (0.53 µg/mL) [ 21 ], following the same dose administration.…”

Section: Discussionmentioning

confidence: 70%

“…After IV administration, Gushi chickens exhibited a volume of distribution at steady state (V SS ) of 3035.00 ± 428.84 mL/kg, which was lower than those observed in Lohmann broiler chickens (10,200 mL/kg) [ 20 ], Japanese quails (8570 mL/kg) [ 10 ], and Jing Hong hens (3500 mL/kg) [ 12 ]. On the other hand, other fluoroquinolones, such as marbofloxacin (1247 mL/kg) in Japanese quail [ 25 ] and enrofloxacin (1060 mL/kg) in cattle [ 26 ], demonstrated lower V SS values.…”

Section: Discussionmentioning

confidence: 99%

“…Danofloxacin concentrations were determined using a previous HPLC method [ 12 ]. Briefly, 0.5 mL of plasma was thoroughly mixed with 1 mL of acetonitrile for 3 min using a vortex.…”

Section: Methodsmentioning

confidence: 99%

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Pharmacokinetics of Danofloxacin in Gushi Chickens after Single Oral and Intravenous Administration

Chen

Li²,

Duan

et al. 2023

Metabolites

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This study aimed to determine the pharmacokinetics of danofloxacin in Gushi chickens after a single oral (PO) and intravenous (IV) dose at 5 mg/kg body weight (BW). Thirty-two Gushi chickens, aged 20 weeks, were selected and divided into two groups at random, with each group consisting of 16 chickens, evenly distributed between males and females. Following danofloxacin administration, blood samples were taken at predetermined time intervals and the plasma was separated. The concentrations of danofloxacin in plasma were quantified by HPLC with a fluorescence detector. Then the concentrations versus time data were subjected to non-compartmental analysis (NCA) using Phoenix software (version: 8.1.0). After administering danofloxacin orally at a dose of 5 mg/kg BW to Gushi chickens, our results demonstrated that the peak concentration reached 0.53 μg/mL at 4 h. The half-life of absorption (t1/2ka) was determined to be 2.37 ± 1.60 h, and the bioavailability (F) was calculated as 40.12 ± 15.83%. For both oral and intravenous administration, the area under the concentration–time curve (AUC0-∞) was determined to be 4.72 ± 1.86 and 11.76 ± 3.25 h·µg/mL, respectively. The corresponding elimination half-life (t1/2λz) was measured as 11.24 ± 3.90 and 10.17 ± 3.72 h. Moreover, the mean residence time (MRT) was calculated as 10.20 ± 2.47 and 7.05 ± 1.97 h for these respective routes. Based on the calculated AUC/MIC ratio values, it can be inferred that the 5 mg/kg BW dosage of danofloxacin, whether administered orally or intravenously, is expected to effectively treat Escherichia coli and Pasteurella multocida infections in Gushi chickens.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

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Pharmacokinetics of Danofloxacin in Gushi Chickens after Single Oral and Intravenous Administration

Chen

Li²,

Duan

et al. 2023

Metabolites

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“…To calculate the first-order rate constant associated with the terminal phase ( λz ), linear regression was used, and from this, the terminal half-life ( t 1/2 λz ) was determined as ln2/ λz . The area under the concentration-time curve ( AUC ) and the first moment curve ( AUMC ) were both calculated using the linear trapezoidal rule with extrapolation to time infinity ( Chen et al, 2023 ). The mean residence time ( MRT ) was obtained by dividing AUMC 0–∞ by AUC 0–∞ .…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetics of meloxicam in pigeons after single intravenous, oral, and intramuscular administration

et al. 2023

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“…This is achieved by inhibiting the catalytic function of both DNA gyrase and topoisomerase IV−two crucial bacterial enzymes responsible for regulating the chromosomal supercoiling necessary for DNA synthesis [ 31 ]. Because of their excellent antibacterial effect, they are widely used in the veterinary field [ 9 , 23 ].…”

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confidence: 99%

Biliary excretion and pharmacokinetics of several fluoroquinolones after intravenous injection in rabbits

SHIMADA,

ABOUBAKR,

ELBADAWY

et al. 2023

J. Vet. Med. Sci.

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The aim of this study was to measure the concentrations of enrofloxacin (ERFX) and other fluoroquinolones; orbifloxacin (OBFX), marbofloxacin (MBFX), and ofloxacin (OFLX) in the plasma and bile of rabbits after a single intravenous (IV) injection. Twenty male rabbits were divided into four groups and given each drug by IV injection into the ear vein at a dose of 5.0 mg/kg BW. The concentration of ERFX, ciprofloxacin (CPFX), OBFX, MBFX and OFLX in plasma and bile were determined by HPLC. CPFX, metabolite of ERFX, was also measured by HPLC in plasma and bile of rabbits receiving ERFX. Several pharmacokinetic parameters in plasma were calculated and biliary clearance (CL bile ) was calculated from extent of biliary excretion and accumulation of AUC of each drug. After IV injection, elimination half-life (t 1/2β ) was 4.13, 3.68, 6.60, 5.14 hr; volume of distribution at a steady state (V dss ) was 1.24, 0.503, 0.771, 1.02 L/kg; and total body clearance (CL tot ) was 1.05, 0.418, 0.271, 0.453 L/kg/hr, respectively. The values for CL bile for ERFX, OBFX, MBFX, and OFLX were 0.0048, 0.0050, 0.0057, and 0.0094 L/kg/hr, respectively. These values represent 0.48%, 1.2%, 2.1%, and 2.3% of the total body clearance (CL tot ) of each drug, respectively. The biliary clearance of CPFX was also measured and found to be 0.0199 L/kg/hr with ERFX administration. The results showed that ERFX, OBFX, MBFX, and OFLX were not excreted into the bile to a significant extent, making them safe drugs to use in rabbits.

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Pharmacokinetics of danofloxacin after single oral and intravenous administration in non‐laying hens

Cited by 4 publications

References 39 publications

Pharmacokinetics of Danofloxacin in Gushi Chickens after Single Oral and Intravenous Administration

Pharmacokinetics of Danofloxacin in Gushi Chickens after Single Oral and Intravenous Administration

Pharmacokinetics of meloxicam in pigeons after single intravenous, oral, and intramuscular administration

Biliary excretion and pharmacokinetics of several fluoroquinolones after intravenous injection in rabbits

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