Pharmacokinetics of dicloxacillin sodium following intravenous and intramuscular administration to domestic cats

Dicloxacillin pharmacokinetics in dogs after intravenous, intramuscular and oral administration

“…The volume of distribution after i.v. administration was comparable to that reported previously for cats, 1974±243 mL/kg (Dimitrova, 1996). This value probably reflects the very high degree of plasma protein binding (90% in dogs) (Gerding et al , 1978).…”

“…This value probably reflects the very high degree of plasma protein binding (90% in dogs) (Gerding et al , 1978). The total body clearance is similar to that reported in cats (16.43±1.19 mL/min.kg) (Dimitrova, 1996). It is however considerably higher than that in humans (109.4–147.8 mL/min) (Nauta & Mattie, 1976).…”

“…injection obtained in the present study is longer than that in humans, cows, rabbits and cats (Yakovlev, 1973; Nauta & Mattie, 1976; Pyörälä et al , 1994; Dimitrova, 1996), Similarly, elimination half‐life values for the extravascular routes in this study are longer than the values reported previously after i.m. dosing in dogs (Gerding et al , 1978), in rabbits (Yakovlev, 1973) and in cats (Dimitrova, 1996) and after p.o. administration in dogs (Plumb, 1991) and in humans (Jusko et al , 1975).…”

“…and i.m. route differ also from that in cats (1.23±0.13 h and 1.39±0.06 h, respectively) (Dimitrova, 1996). It could be assumed that the higher values of half‐life and of MRT for the extra‐vascular routes are related to the respective rate of absorption.…”

“…The pharmacokinetic behaviour of this antibiotic in different animal species has also been studied (Yakovlev, 1973; Cars et al , 1981; Tsuji & Nakashima, 1981; Cars et al , 1982; Tsuji et al , 1983; Pyörälä et al , 1994; Dimitrova, 1996). The disposition kinetics after intravenous (i.v.)…”