Pharmacokinetics of Flavanone Glycosides after Ingestion of Single Doses of Fresh-Squeezed Orange Juice versus Commercially Processed Orange Juice in Healthy Humans

Silveira, Jacqueline Queiroz da; César, Thaís Borges; Manthey, John A.; Baldwin, Elizabeth A.; Bai, Jinhe; Raithore, Smita

doi:10.1021/jf5038163

Cited by 55 publications

(48 citation statements)

References 47 publications

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“…These conflicting results between in vivo and in vitro examinations may be explained by the metabolism of narirutin in a living body. Pharmacokinetics of narirutin after ingestion of orange juice in healthy humans were reported by Silveria et al [27] . The majority of oral intake-narirutin is considered to reach the colon, and colonic microbiota deglycosylate narirutin to naringenin, that is then absorbed by colonocytes [28] .…”

Section: Discussionmentioning

confidence: 86%

Anti-inflammatory effects of flavonoids in Citrus jabara fruit peels

Azuma

Murakami²,

Azuma³

et al. 2018

Trends Immunother

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Currently, about half of people in Japan suffer from allergic diseases. Thus, Citrus jabara fruits have been paid attention as one of quite effective anti-allergic functional foods. C. jabara is an endemic species originally grown only in Kitayama village, Wakayama prefecture in Japan. Although genetic characterization and diversity of various Citrus fruits including C. jabara were researched, but there is room for the study on flavonoids characteristics in C. jabara fruit. For the alleviation of allergic symptom, anti-inflammatory effects are also important. In this study, characteristics of flavonoids in C. jabara fruit peels, and the anti-inflammatory effects of these purified flavonoids were investigated. Our results revealed that C. jabara is a unique Citrus that almost all of flavonoids in fruit peels was narirutin. There was no Citrus species with a flavanone glycosides content ratio like C. jabara. Although anti-inflammatory effects of narirutin was weak, but its aglycone naringenin exhibited following inhibitory effects: nitric oxide synthesis (IC 50 = 105 μM), nitric oxide synthase induction, Interleukin-6 synthesis (IC 50 = 65 μM), and inducible soluble epoxide hydrolase activity (IC 50 = 267 μM). Since narirutin is deglycosylated to naringenin that is then absorbed by colonocytes, it is considered that narirutin exists like a prodrug and its aglycone naringenin works as an active form of anti-inflammatory effect in a living body at oral ingestion of C. jabara fruit peels. Keywords: Citrus jabara; anti-inflammatory effects; flavonoids; narirutin; naringenin ARTICLE INFO

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Section: Discussionmentioning

confidence: 86%

Anti-inflammatory effects of flavonoids in Citrus jabara fruit peels

Azuma

Murakami²,

Azuma³

et al. 2018

Trends Immunother

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“…Indeed, an analytical evaluation revealed that the qualitative composition is not changed, but quantitative analysis highlights significant differences [76]. However, the matrix factor is not the most critical.…”

Section: Pharmacokinetic Profile Of Citrus Flavanonesmentioning

confidence: 99%

Nutraceutical Value of Citrus Flavanones and Their Implications in Cardiovascular Disease

2017

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Background- Cardiovascular diseases, including myocardial infarction, dyslipidaemia and coronary artery pathology, are a major cause of illness and death in Western countries. Therefore, identifying effective therapeutic approaches and their cellular signalling pathways is a challenging goal for medicine. In this regard, several epidemiological studies demonstrate a relationship between the intake of flavonoid-rich foods and the reduction of cardiovascular risk factors and mortality. In particular, flavonoids present in citrus fruits, such as oranges, bergamots, lemons and grapefruit (95% from flavanones), are emerging for their considerable nutraceutical value. Methods- In this review an examination of literature was performed while considering both epidemiological, clinical and pre-clinical evidence supporting the beneficial role of the flavanone class. We evaluated studies in which citrus fruit juices or single flavanone administration and cardiovascular risk factors were analysed; to identify these studies, an electronic search was conducted in PUBMED for papers fulfilling these criteria and written in English. Results- In addition to epidemiological evidence and clinical studies demonstrating that fruits in the Citrus genus significantly reduce the incidence of cardiovascular disease risk, pre-clinical investigations highlight cellular and subcellular targets that are responsible for these beneficial effects. There has been special attention on evaluating intracellular pathways involved in direct cardiovascular and cardiometabolic effects mediated by naringenin, hesperetin and eriodictyol or their glycosylated derivatives. Conclusions- Although some mechanisms of action remain unclear and bioavailability problems remain to be solved, the current evidence supports the use of a nutraceutical approach with citrus fruits to prevent and cure several aspects of cardiovascular disease.

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“…Human intervention studies with hesperidin and food products containing hesperidin such as orange juice, have led to the identification and quantification of hesperidin‐derived metabolites in both plasma and urine . In addition, to elucidate the mechanisms of hesperidin conversion throughout the gastrointestinal tract, various batch and continuous luminal digestion models simulating enzymatic and microbial degradation were set up.…”

Section: Introductionmentioning

confidence: 99%