Pharmacokinetics of florfenicol and its metabolite florfenicol amine in crucian carp (Carassius auratus) at three temperatures after single oral administration

Yang, Fan; Wang, Guoyong; Kong, Tao; Liu, Baobao

doi:10.1016/j.aquaculture.2019.01.037

Cited by 36 publications

(28 citation statements)

References 25 publications

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“…Thirdly, putrefaction can also contribute to changes in drug concentrations after death [29][30][31] . Combined that the previous founding that pharmacokinetic profiles of drugs were affected by environment temperature in animal models 32,33 , the rate of postmortem metabolism may also affected by the temperature of corpses preservation 29,30 . In our present study, we found that the highest canthardin concentration in rats liver and kidney was 72 h after death which may be related to the rate of postmortem cantharidin metabolism and body decomposition at the constant temperature of 20 °C and whether there were differences in the postmortem changes of cantharidin concentration among different temperatures of corpses preservation need to be further studied.…”

Section: Limit Of Detection Limit Of Quantitation and Linearity Srmmentioning

confidence: 77%

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) determination of cantharidin in biological specimens and application to postmortem interval estimation in cantharidin poisoning

Zhang

Ren

2020

Sci Rep

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A rapid, sensitive liquid chromatography-tandem mass spectrometry (Lc-MS/MS) method was developed and validated for the determination and quantification of cantharidin in rats liver and kidney. After grinding with methanol, the supernatant was determined by Lc-MS/MS using an thermo Accucore C18 column (100 mm×2.1 mm, 2.6 μm) with a gradient elution of 0.1% formic acid and 0.1% acetonitrile, and in the subsequent analysis using selected reaction monitoring mode, three ion transitions were monitored for analyte. The limit of detection (LOD) was 0.741 ng/ml and the limit of quantitation (LOQ) was 2.471 ng/ml. Good linearity (R 2 = 0.9998) was observed for the analyte over the linear range (5-400 ng/ml). The LC-MS/MS method was applied to the analysis of rats liver and kidney in different postmortem intervals (6 h, 12 h, 24 h, 48 h, 72 h and 168 h after death) after a single dose (4 mg/kg) of cantharidin administration by gavage. At 72 h after death, the cantharidin concentration in livers and kidneys were significantly higher than that in other postmortem intervals. Linear regression equations between postmortem interval and lg postmortem cantharidin concentration in rats liver and kidney were Y = 0.007455*X + 1.332(R 2 = 0.863) and Y = 0.002689*X + 1.433 (R 2 = 0.115) respectively. the animal experiment demonstrated Lc-MS/MS method can be used to determine the postmortem cantharidin concentration in rats liver and kidney and the determination of cantharidin in the rats liver after death has potential value for postmortem interval estimation in cantharidin poisoning. Cantharidin, as the principal active ingredient of traditional Chinese medicine mylabris, was firstly discovered and used as anticancer drug in China 1. What is more, cantharidin-based pharmaceutical preparations, such as Fufangbanmao caspsules and Aidi injection, are now widely used in clinical treatment for cancers with good therapeutic efficacy 2-4. However, previous studies on the clinical efficacy and safety of cantharidin indicated that cantharidin had risk of hematotoxicity, gastrointestinal toxicity, liver or renal injury, neurotoxicity, cardiotoxicity and so on 5-7. Furthermore, many village doctors use the unprocessed mylabris for treatment in patients and the effects of different processing to pharmacodynamic action of canthardin were different 8,9. All of these lead to the lack of unified evaluation criteria for clinical efficacy and safety. As we know, the toxic dosage of cantharidin was similar to therapeutic dosage 10 and the potential risk of cantharidin poisoning far outweighs any potential benefit of therapeutic efficacy was caused by the unreasonable use or inappropriate medication in patients. Evenmore, cantharidin poisoning can lead to muti-organ failure even death 8 and the following conditions of cantharidin poisoning were also found in forensic identification center 8,11-14 such as patients who died after ingestion of cantharidin as aphrodisiac, ingested blister beetles accidentally, suicide by ingesting mylabris, homicide by poi...

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Section: Limit Of Detection Limit Of Quantitation and Linearity Srmmentioning

confidence: 77%

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) determination of cantharidin in biological specimens and application to postmortem interval estimation in cantharidin poisoning

Zhang

Ren

2020

Sci Rep

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“…So, the statistical moment parameters are shown in Tables 6 and 7. In the compartmental model analysis, various models and different statistical weights were compared in this work, and two-compartment parameters were found to be the optimal fitting values with the minimum AIC (Akaike's Information Criterion) and the best R (correlation coefficient) values (Yuan et al, 2017;Yang et al, 2019). The compartmental model parameters are shown in Tables S1 and S2.…”

Section: Discussionmentioning

confidence: 99%

Multi-Component Comparative Pharmacokinetics in Rats After Oral Administration of Fructus aurantii Extract, Naringin, Neohesperidin, and Naringin-Neohesperidin

et al. 2020

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Citrus × aurantium L., Chinese name: Fructus Aurantii (FA) has been largely used as Qiinvigorating herb in China for centuries. The main components (meranzin hydrate, naringin, neohesperidin, meranzin, nobiletin) have good physiological activity with relatively high abundance in FA. Few multi-component comparative pharmacokinetics are simultaneously accessible for the flavone glycosides, polymethoxy flavones, and coumarins in FA. In this work, a reliable and rapid ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was established and validated to determine the five ingredients in the SD rat plasma, and further applied to the pharmacokinetic studies after oral administration of monomer, drugs in compatibility, and FA extract. After hydrolysis with b-glucuronidase and sulfatase, the concentration of naringin and neohesperidin in rat plasma were expressed respectively by the total concentration of naringenin and hesperitin which was determined by UPLC-MS/MS. Double-peak phenomenon was observed for naringin and neohesperidin, which may be due to the enterohepatic circulation or multiple site absorption of the two flavone glycosides. Meranzin hydrate and meranzin (coumarins) were absorbed rapidly (T max, about 1.0 h) but eliminated slowly (t 1/2z exceeds 6.5 h). Nobiletin, a typical polymethoxy flavone, was also rapidly absorbed according to T max and AUC (0-t) . DAS 3.1 software suggests the pharmacokinetic profiles of the five components in rats be depicted as a two-compartment pharmacokinetic model. There were significant differences in pharmacokinetic parameters for naringenin and hesperetin between the compatibility, FA extract group vs monomer group: ① remarkable increases in the values of AUC (0-∞) , AUC (0-t) and C max ; ② obvious decrease of CL Z/F ; and ③ longer t max and t 1/2z . The results suggest that compatibility can promote mutual absorption and affect the elimination behaviors.

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“…There are many factors affecting the pharmacokinetics and residue elimination times in aquatic animals including species and physiological differences, dosage, route of administration, temperature, salinity, and pH. Among these factors, water temperature is the most influential (Yang et al, ; Yang, Yang, Wang, Kong, & Liu, ). Therefore, the clinical withdrawal period should be determined according to the specific fish species and the actual breeding environment.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and tissue residues of enrofloxacin in the largemouth bass (Micropterus salmoides) after oral administration

Qi¹,

Wang

Zheng³

et al. 2019

Vet Pharm & Therapeutics

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The study was carried out to evaluate the pharmacokinetic disposition of enrofloxacin (ENF) with a single dose of 20 mg/kg after oral administration in largemouth bass (Micropterus salmoides) at 28°C. The concentrations of ENF and of its metabolite ciprofloxacin (CIP) in plasma, liver, and muscle plus skin in natural proportions were determined using HPLC. The concentration–time data for ENF in plasma were best described by a two‐compartment open model. After oral administration, the maximum ENF concentration (Cmax) of 10.99 μg/ml was obtained at 0.60 hr. The absorption half‐life (T1/2Ka) of ENF was calculated to be 0.07 hr whereas the elimination half‐life (T1/2β) of the drug was 90.79 hr. The estimates of area under the plasma concentration–time curve (AUC) and apparent volume of distribution (Vd/F) were 1,185.73 μg hr/ml and 2.21 L/kg, respectively. ENF residues were slowly depleted from the liver and muscle plus skin of largemouth bass with the T1/2β of 124.73 and 115.14 hr, respectively. Very low levels of ciprofloxacin were detected in the plasma and tissues. A withdrawal time of 24 days was necessary to ensure that the residues of ENF + CIP in muscle plus skin were less than the maximal residue limit (MRL) of 100 μg/kg established by the European Union.

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Pharmacokinetics of florfenicol and its metabolite florfenicol amine in crucian carp (Carassius auratus) at three temperatures after single oral administration

Cited by 36 publications

References 25 publications

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) determination of cantharidin in biological specimens and application to postmortem interval estimation in cantharidin poisoning

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) determination of cantharidin in biological specimens and application to postmortem interval estimation in cantharidin poisoning

Multi-Component Comparative Pharmacokinetics in Rats After Oral Administration of Fructus aurantii Extract, Naringin, Neohesperidin, and Naringin-Neohesperidin

Pharmacokinetics and tissue residues of enrofloxacin in the largemouth bass (Micropterus salmoides) after oral administration

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