Pharmacokinetics of glycopeptide antibiotics in children

Ito, Hidekazu; Shime, Nobuaki; Kosaka, Toshio

doi:10.1007/s10156-012-0458-8

Cited by 15 publications

(9 citation statements)

References 15 publications

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“…Therapeutic trough vancomycin concentrations range from 5 mg/L to 25 mg/L [8,12]. Thus, reports on the number of subjects with sub-therapeutic levels of vancomycin show wildly varying results, with reported percentages ranging from 24% to 58% [13,14]. In the present study, approximately half of the neonates had initial trough serum concentrations in the sub-therapeutic range after the administration of the recommended dosing regimen.…”

Section: Discussionmentioning

confidence: 66%

Inadequate vancomycin therapy in term and preterm neonates: a retrospective analysis of trough serum concentrations in relation to minimal inhibitory concentrations

Sinkeler¹,

Haan

Hodiamont

et al. 2014

BMC Pediatr

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BackgroundVancomycin is effective against gram-positive bacteria and the first-line antibiotic for treatment of proven coagulase-negative staphylococcal infections. The aim of this study is bipartite: first, to assess the percentage of therapeutic initial trough serum concentrations and second, to evaluate the adequacy of the therapeutic range in interrelationship with the observed MIC-values in neonates.MethodsIn this study, preterm and term neonates admitted at a tertiary NICU in the Netherlands from January 2009 to December 2012 and treated with vancomycin for a proven gram-positive infection were included. Trough serum concentrations were measured prior to administration of the 5th dose. Trough concentrations in the range of 10 to 15 mg/L were considered therapeutic. Staphylococcal species minimal inhibitory concentrations (MIC’s) were determined using the E-test method. Species identification was performed by matrix-assisted laser desorption/ionisation mass spectrometry.ResultsOf the 112 neonates, 53 neonates (47%) had sub-therapeutic initial trough serum concentrations of vancomycin, whereas 22% had supra-therapeutic initial trough serum concentrations. In all patients doses were adjusted on basis of the initial trough concentration. In 40% (23/57) of the neonates the second trough concentration remained sub-therapeutic. MIC’s were determined for 30 coagulase-negative Staphylococcus isolates obtained from 19 patients. Only 4 out of 19 subjects had a trough concentration greater than tenfold the MIC.ConclusionsForty-seven percent of the neonates had sub-therapeutic initial trough serum concentrations of vancomycin. The MIC-data indicate that the percentages of underdosed patients may be greater. It may be advisable to increase the lower limit of the therapeutic range for European neonates.

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Section: Discussionmentioning

confidence: 66%

Inadequate vancomycin therapy in term and preterm neonates: a retrospective analysis of trough serum concentrations in relation to minimal inhibitory concentrations

Sinkeler¹,

Haan

Hodiamont

et al. 2014

BMC Pediatr

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“…[9][10][11][12][13] Given age-related differences in renal function and hence vancomycin clearance, it would seem that vancomycin dosing strategies should be adjusted according to age.…”

mentioning

confidence: 99%

Achieving Therapeutic Vancomycin Levels in Pediatric Patients

Hoang

Dersch‐Mills

Bresee

et al. 2014

CJHP

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“…Teicoplanin, another member of glycopeptides family, is widely used in Europe and Japan, but is not approved for use in the United States . It provides bactericidal activity against gram‐positive infections, with similar clinical efficacy to vancomycin .…”

Section: Antimicrobial Treatment In Drug‐resistant Capmentioning

confidence: 99%

“…Teicoplanin presents a long elimination half‐life, which means that once daily administration is possible. However, because it takes a long time to achieve an optimal plasma concentration, an initial loading‐dose regimen has been recommended . A teicoplanin MIC value >1.5–2 mg/L is associated with an increased risk of treatment failure among patients with MRSA pneumonia and bacteraemia .…”

Section: Antimicrobial Treatment In Drug‐resistant Capmentioning

confidence: 99%