Pharmacokinetics of Hu-Pi-Cheng-Qi decoction administered via enema to rats with acute pancreatitis

Wu, Qiu-Ting; Chen, Huan; Xiang, Jin; Tang, Wen-Fu; Wan, Mei-Hua

doi:10.1097/cm9.0000000000000853

Cited by 6 publications

(2 citation statements)

References 4 publications

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“…FRVC, evolved from enema, is to inject liquid directly and continuously into the colon. Large intestine enema, as an adjuvant therapy for acute pancreatitis, was believed to reduce the frequency of infectious complications by reducing bacterial translocation 15 and allow the active ingredients of certain drugs to be absorbed into the blood circulation 16,17 . However, the clinical application of FRVC has not been promoted.…”

Section: Discussionmentioning

confidence: 99%

Fluid Resuscitation via Colon Alleviates Systemic Inflammation in Early Stage of Rats With Severe Acute Pancreatitis

Tien

Sun

et al. 2021

Preprint

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Fluid Resuscitation Via Colon (FRVC) is a complementary therapy for severe acute pancreatitis (SAP) in early stage. The expression of intestinal dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) has been found to regulate systemic inflammation. The present study aimed to investigate the effect of FRVC on the expression of DC-SIGN in the colon tissue of SAP rats and its effect on the early response of systemic inflammatory and multiple organ injury. SAP rats were induced by retrograding injection of sodium taurocholate into biliopancreatic duct. The expression of DC-SIGN was observed in the proximal and distal colons. Histological characteristics and inflammatory cytokines were examined to compare the effect of FRVC and intravenous fluid resuscitation (IVFR) treatment. The results showed that the expression of DC-SIGN in the proximal colon increased in a time-dependent manner in early stage of SAP rats. FRVC inhibits the expression of DC-SIGN in the proximal colon. Both FRVC and IVFR treatment alleviates histological injury of pancreas and colon. However, FRVC had an advantage over IVFR in alleviating lung injury and reducing Serum TNF-α, IL-6 and LPS. These results suggest that FRVC treatment might be helpful in suppressing systemic inflammation and preventing subsequent organ failure in early stage of SAP rats. The mechanism might be to inhibit the expression of DC-SIGN protein in the proximal colon.

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Section: Discussionmentioning

confidence: 99%

Fluid Resuscitation via Colon Alleviates Systemic Inflammation in Early Stage of Rats With Severe Acute Pancreatitis

Tien

Sun

et al. 2021

Preprint

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“…It is a measure that allows the body to actively regulate water absorption and hemodynamics through colonic aquaporin 10 . FRVC has been proved to be effective in animal experiments 11 , 12 . There are also reports on the use of drugs or traditional Chinese medicine via colon 13 – 16 .…”

Section: Introductionmentioning

confidence: 99%

The impact of fluid resuscitation via colon on patients with severe acute pancreatitis

Tien

Chen

Zhao

et al. 2021

Sci Rep

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Severe acute pancreatitis (SAP) is a life-threatening disease. Fluid Resuscitation Via Colon (FRVC) may be a complementary therapy for early controlled fluid resuscitation. But its clinical application has not been reported. This study aims to explore the impact of FRVC on SAP. All SAP patients with the first onset within 72 h admitted to the hospital were included from January 2014 to December 2018 through electronic databases of Ruijin hospital and were divided into FRVC group (n = 103) and non-FRVC group (n = 78). The clinical differences before and after the therapy between the two groups were analyzed. Of the 181 patients included in the analysis, the FRVC group received more fluid volume and reached the endpoint of blood volume expansion ahead of the non-FRVC group. After the early fluid resuscitation, the inflammation indicators in the FRVC group were lower. The rate of mechanical ventilation and the incidence of hypernatremia also decreased significantly. Using pure water for FRVC was more helpful to reduce hypernatremia. However, Kaplan–Meier 90-day survival between the two groups showed no difference. These results suggest that the combination of FRVC might benefit SAP patients in the early stage of fluid resuscitation, but there is no difference between the prognosis of SAP patients and that of conventional fluid resuscitation. Further prospective study is needed to evaluate the effect of FRVC on SAP patients.

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Efficacy and safety of early enteral and intravenous fluid resuscitation in severe acute pancreatitis: a systematic review and meta-analysis

Liu

Qiu

Yang

et al. 2023

Int J Colorectal Dis

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Pharmacokinetics of Hu-Pi-Cheng-Qi decoction administered via enema to rats with acute pancreatitis

Cited by 6 publications

References 4 publications

Fluid Resuscitation via Colon Alleviates Systemic Inflammation in Early Stage of Rats With Severe Acute Pancreatitis

Fluid Resuscitation via Colon Alleviates Systemic Inflammation in Early Stage of Rats With Severe Acute Pancreatitis

The impact of fluid resuscitation via colon on patients with severe acute pancreatitis

Efficacy and safety of early enteral and intravenous fluid resuscitation in severe acute pancreatitis: a systematic review and meta-analysis

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