Pharmacokinetics of <i>Trans</i>‐resveratrol Following Repeated Administration in Healthy Elderly and Young Subjects

Nunes, Teresa; Almeida, Luís; Rocha, José‐Francisco; Falcão, Amı́lcar; Fernandes-Lopes, Carlos; Loureiro, Ana; Wright, Lyndon; Vaz‐da‐Silva, Manuel; Soares‐da‐Silva, Patrício

doi:10.1177/0091270009339191

Cited by 102 publications

(79 citation statements)

References 17 publications

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“…Chow et al reinforced those findings and demonstrated that 1 g resveratrol taken once daily for 4 week was generally well tolerated in healthy participants (Chow et al, 2010): all the reported adverse events were CTC grade 1 or 2, with many being mild and transient. The frequency of the side effects experienced was consistent with that observed in a trial described by Brown et al (Brown et al, 2010) and in shorter-term studies involving fractionated daily doses (la Porte et al, 2010;Almeida et al, 2009;Nunes et al, 2009).…”

Section: Toxicity Of Resveratrolsupporting

confidence: 87%

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

Carrizzo

Forte

Damato

et al. 2013

Food and Chemical Toxicology

174

105

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a b s t r a c tResveratrol-a natural polyphenolic compound-was first discovered in the 1940s. Although initially used for cancer therapy, it has shown beneficial effects against most cardiovascular and cerebrovascular diseases. A large part of these effects are related to its antioxidant properties. Here we review: (a) the sources, the metabolism, and the bioavailability of resveratrol; (b) the ability of resveratrol to modulate redox signalling and to interact with multiple molecular targets of diverse intracellular pathways; (c) its protective effects against oxidative damage in cardio-cerebro-vascular districts and metabolic disorders such as diabetes; and (d) the evidence for its efficacy and toxicity in humans. The overall aim of this review is to discuss the frontiers in the field of resveratrol's mechanisms, bioactivity, biology, and healthrelated use.

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Section: Toxicity Of Resveratrolsupporting

confidence: 87%

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

Carrizzo

Forte

Damato

et al. 2013

Food and Chemical Toxicology

174

105

View full text Add to dashboard Cite

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“…The poor oral bioavailability [14] considerably less than 1% would attribute to different the metabolic issue [44], such as very short half-life in rat liver microsomes. Furthermore, poor oral bioavailability is due to the first-pass metabolism in intestine [45,46], while increased dose and repeated dose escalation would not affect the bioavailibity. Therefore, this study was carried out to evaluate the pharmacokinetic properties of resveratrol using the novel technique known as The Trivedi Effect ® -Energy of Consciousness Healing Treatment on resveratrol and animals.…”

Section: Resultsmentioning

confidence: 99%

The Influence of Energy of Consciousness Healing Treatment on Low Bioavailable Resveratrol in Male Sprague Dawley Rats

Branton¹

2017

IJCDA

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Abstract:Resveratrol is a natural dietary antioxidant polyphenol that believed to be effective in improving overall health.The biological activity of resveratrol is limited by its poor absorption and first-pass metabolism that lead to have very low plasma concentrations following oral administration. Therefore, the present study was performed to determine the effects of The Trivedi Effect ® -Energy of Consciousness Healing Treatment by a renowned Biofield Energy Healer, Alice Branton on resveratrol and rats through the measurement of plasma concentrations after oral administration of resveratrol. The test item, resveratrol was divided into two parts. One part was denoted as the control, while the other part was defined as the Biofield Energy Treated sample. Additionally, one group of animals also received Biofield Energy Treatment under similar conditions. Resveratrol oral formulations were administrated by oral gavage at a dose of 150 mg/kg in groups viz. G1 (untreated resveratrol), G2 (Biofield Treated resveratrol) and G3 (Biofield Treated animals received untreated resveratrol) group. The results showed that resveratrol had a very low oral plasma exposure of 91.71 ng/mL in control group. The Biofield Treatment significantly enhanced the relative oral exposure (AUC 0-t ) of resveratrol by 23.35% in G2 group compared to the control group. The Biofield Treatment also improved plasma peak concentration (C max ) of resveratrol by 125% and 28.5% in G2 and G3 groups, respectively compared with the control group. Plasma concentrations of resveratrol in G1 was declined with a rapid elimination half-life (T 1/2 , 1.48 hours), followed by sudden increases in plasma concentrations 12 to 24 hours after the test item administration. These plasma concentrations resulted in a significant prolongation of the terminal elimination half-life of resveratrol. The oral elimination T 1/2 of resveratrol in G2 and G3 were 4.67 and 9.0 hours, respectively as compared to the G1. The apparent oral plasma clearance of resveratrol decreased significantly by 54%, and 17.5% in G2 group and G3 group, respectively as compared to the control group. The mean residence time (MRT last ) of resveratrol significantly increased in G2 group (6.45 hours) and G3 group (7.70 hours), as compared to the control group. These data demonstrates greater bioavailability and total plasma level of resveratrol in rats which might be translated into better in vivo biological activity. Hence, The Trivedi Effect ® -Energy of Consciousness Healing Treatment could be considered as an innovative strategy which opens new avenues to overcome poorly absorbed nutraceuticals/pharmaceuticals and can also improve the therapeutic performance of orally active molecules.

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“…Several Phase I/II clinical trials are currently underway for orally administrated RSV in humans, and these studies reveal that after RSV administration daily for 29 days in 40 healthy volunteers, no significant adverse effects were observed, only mild to moderate gastrointestinal symptoms with 2.5 and 5.0 g of RSV [77]. Other reports on trials of RSV in humans after single [44,74] or multiple daily doses of up to 600 mg/day administered over 2-3 days [79,80], show that RSV is safe under the tested conditions. In this study, circulating levels of major RSV metabolites, RSV-3-O-sulphate, RSV-4 0 -O-glucuronide and RSV-3-Oglucuronide, were much higher, particularly in the case of the sulphate.…”

Section: Impact Of Rsv Transport On Its Bioavailability and Its Biolomentioning

confidence: 99%

Role of membrane dynamics processes and exogenous molecules in cellular resveratrol uptake: Consequences in bioavailability and activities

Delmas

Lin

2011

Molecular Nutrition Food Res

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In the fields of nutrition prevention and therapy treatment, numerous studies have reported interesting properties of trans-resveratrol (RSV), a natural polyphenol against pathologies such as vascular diseases, cancers, viral infections and neurodegenerative processes. These beneficial effects are supported by more studies showing the pleiotropic actions of RSV. Nevertheless, a crucial question concerning these effects is how the polyphenol, when applied to an organism, gains access to its targets. In this review, we focus on the biochemical and biological parameters involved in RSV transport, particularly the role of the phospholipid bilayer in RSV uptake (passive diffusion, carrier-mediated transport) and of exogenous molecules modulating RSV transport and effects. The dynamic processes of the plasma membrane reveal the importance of the role of lipid composition in the fluidity, the lipid rafts in RSV endocytosis and the ATP-binding cassette transporters in RSV efflux. Specific membrane receptors such as integrin αvβ3 contribute to RSV uptake and to activate signalling pathways involved in apoptosis. We discuss the role of intracellular receptors (i.e. aryl-hydrocarbon and estrogen receptors). In addition, circulating molecules (i.e. albumin, haemoglobin, fatty acids, lipoproteins) play a role as RSV carriers. Finally, we developed a hypothesis concerning the relation between RSV uptake and its biological activities.

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Pharmacokinetics of Trans‐resveratrol Following Repeated Administration in Healthy Elderly and Young Subjects

Cited by 102 publications

References 17 publications

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

The Influence of Energy of Consciousness Healing Treatment on Low Bioavailable Resveratrol in Male Sprague Dawley Rats

Role of membrane dynamics processes and exogenous molecules in cellular resveratrol uptake: Consequences in bioavailability and activities

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