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REPORT DATE (DD-MM-YYYY)01/06/07 (From -To)
REPORT TYPE
Annual
DATES COVERED
PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERUniversity of California Irvine, CA 92697
SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S)
U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012
SPONSOR/MONITOR'S REPORT NUMBER(S)
DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited
SUPPLEMENTARY NOTES
ABSTRACT:This study proposes to modify and improve an existing MR-compatible optical tomography system that is used for non-invasive tumor characterization and provides higher sensitivity and specificity for cancer imaging. The proposed research will conduct animal studies to evaluate the system's performance in distinguishing malignant from benign tumors in vivo. Additional experiments will be designed to assess the method's sensitivity to quantifying oxygenation gain factor in breast tumors. This investigation will have important implications for studies identifying tumor's hypoxic regions. Tumor hypoxia is believed to be strongly associated with tumor progression, prognosis, and resistance to therapy. In the first year of this multidisciplinary postdoctoral training grant, the principal investigator acquires training in breast cancer and dynamic contrast enhanced MRI. The major focus is on optical imaging system development/improvement and performance evaluation through phantom studies. We managed to increase the data acquisition speed by a factor of 10, which enabled us to perform dynamic contrast enhanced diffuse optical tomography on phantoms for the first time.
SUBJECT TERMS
INTRODUCTIONIn the last decade a variety of multi-modality imaging techniques have been developed to obtain complementary information and cross-validate measurements to investigate the differences in the physiological properties of benign and malignant tumors, and hence make tumor assessment more reliable. Magnetic resonance imaging (MRI) and near-infrared diffuse optics are non-invasive techniques that provide compleme...