Pharmacokinetics of indomethacin in cattle

Cristòfol, Carles; Valladares, Josep Enric; Franquelo, Carme; Martí, G.; Arboix, M.

doi:10.1111/j.1365-2885.1996.tb00012.x

Cited by 6 publications

(14 citation statements)

References 16 publications

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“…The mean body clearance rates (0.17 and 0.22 L/h.kg, i.v. and i.m., respectively) of drug were similar to those reported in dogs (0.19 L/h.kg), slightly higher than in humans (0.044–0.109 L/h.kg) but lower than reported in cattle (2.5 L/h.kg) (Cristofol et al ., 1996). The alkaline urine pH of ruminants (7.0–8.0) favours excretion of weakly acidic drugs such as indomethacin (pKa = 4.5).…”

Section: Discussionsupporting

confidence: 88%

“…administration. The elimination phase parameters (elimination half‐lives after i.v., 17.4 h and i.m., 21.25 h routes) were longer than those reported for cattle (5.3 h) (Cristofol et al ., 1996), dogs (7.89 h) (Cocigglio et al ., 1991) and humans (2.6–11.2 h) (Duggan et al ., 1972; Alvan et al ., 1975) after intravenous administration (Table 4). Although neither rate constants (β = 4.19 × 10 ‐2 h ‐1 and 3.38 × 10 ‐2 h ‐1 , i.v.…”

Section: Discussionmentioning

confidence: 62%

“…(1 mg/kg) and i.m. (1 mg/kg) administrations to sheep, as well as those reported in various domestic animals (Cociglio et al ., 1991; Cristofol et al ., 1996) and humans (Duggan et al ., 1972; Alvan et al ., 1975), including preterm infants (Friedman et al ., 1991), have been best described using a two‐compartment model.…”

Section: Discussionmentioning

confidence: 99%

“…The V dss of indomethacin reported for other species, dogs 1.27 L/kg (Cociglio et al ., 1991), humans 0.34–1.57 L/kg (Alvan et al ., 1975) and rats 0.179 L/kg (Ogiso et al ., 1994) were small possibly because the high percentage of plasma protein binding restricts extravascular distribution. However, the V dss for indomethacin in cattle (12.2 l/kg) (Cristofol et al ., 1996) was larger than reported in this study in sheep. The high V dss values in ruminants is consistent with the possible diffusion of the drug into the forestomach system.…”

Section: Discussionmentioning

confidence: 99%

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Pharmacokinetics of indomethacin in sheep after intravenous and intramuscular administration

Vinagre

Rodríguez

Andrés

et al. 1998

Vet Pharm & Therapeutics

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The pharmacokinetics of indomethacin (1 mg/kg) was determined in six adult sheep after intravenous (i.v.) and intramuscular (i.m.) injection. Plasma concentrations were maintained within the therapeutic range (0.3-3.0 microg/mL) from 5 to 50 min after i.v. and from 5 to 60-90 min after i.m. administration. After two trials, indomethacin best fitted an open two-compartment model. The mean (+/- SD) volumes of distribution at steady state (Vd(ss)) were 4.10 +/- 1.40 and 4.21 +/- 1.93 L/kg and the mean clearance values (ClB) were 0.17 +/- 0.06 and 0.22 +/- 0.12 L/h x kg for i.v. and i.m. routes, respectively. The elimination phase half-lives did not show any significant difference between routes of injection (t1/2beta = 17.4 +/- 4.6 and 21.25 +/- 4.44 h, i.v. and i.m. respectively). After i.m. administration, plasma maximum concentration (Cmax = 1.10 +/- 0.68 microg/mL) was reached 10 min after dosing; the absorption phase was fast (Kab = 26 +/- 18 h(-1)) and short (t1/2ab = 2.33 +/- 1.51 min) and the mean bioavailability was 91.0 +/- 32.8%, although there was considerable interanimal variation. In some individuals, bioavailability was higher than 100%. This fact combined with the slower elimination phase after i.m. than after i.v. administration, could be related with enterohepatic recycling.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pharmacokinetics of indomethacin in sheep after intravenous and intramuscular administration

Vinagre

Rodríguez

Andrés

et al. 1998

Vet Pharm & Therapeutics

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“…Several papers have reported the pharmacokinetics of indomethacin in humans and other species (Hucker et al ., 1966; Alvan et al ., 1975). In ruminant species, plasma pharmacokinetics of indomethacin has been studied after intravenous injection in cattle (Cristofol et al ., 1996) and sheep (Vinagre et al ., 1998).…”

Section: Introductionmentioning

confidence: 99%

Chronobiological variations of indomethacin pharmacokinetic parameters in sheep

Boggio

Valtorta

Sánchez

et al. 2001

Vet Pharm & Therapeutics

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A two-phase study to investigate the influence of administration time on pharmacokinetics of indomethacin in sheep was performed. In phase I, 12 animals were allocated to four groups, each corresponding to a different time: 08:00, 14:00, 20:00, 02:00 h. Sheep received an intravenous administration of 1 mg/kg indomethacin. In phase II, each group was administered indomethacin with a 12-h difference compared to Phase I. The trial was performed in autumn, and animals were subjected to a natural light:dark cycle of 10:14 h. Blood samples were taken and processed by high performance liquid chromatography (HPLC) with ultraviolet detection. For each pharmacokinetic parameter, an analysis of variance was performed to outline the existence of chronobiological variations. Concentration at zero time (C0), hybrid constant for distribution and its half life, hybrid constant for elimination and its half-life, volume of distribution (V(d)), area under the curve (AUC(infinity)) and clearance rate (Cl), presented chronobiological variations (P < 0.05) and were fitted to a cosine equation. The following parameters adjusted to circadian rhythms: C(0) (acrophase: 13.9788 h); AUC(infinity) (acrophase: 13.4377 h); V(d) (acrophase: 0.8245 h) and Cl (acrophase: 1.4965 h). It was concluded that pharmacokinetic parameters of intravenously injected indomethacin in sheep would behave in a different, though predictable, manner according to the animal's biological clock.

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