Pharmacokinetics of Ivermectin (Noromectin®) Following Single Dose 	Subcutaneous Administration in Sheep

Sakthikarthikeyan, S.; Ahmad, Aziz; Kannan, Karuppiah

doi:10.20546/ijcmas.2020.906.497

Int.J.Curr.Microbiol.App.Sci

2020

DOI: 10.20546/ijcmas.2020.906.497

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Pharmacokinetics of Ivermectin (Noromectin®) Following Single Dose Subcutaneous Administration in Sheep

S. Sakthikarthikeyan¹,

Aziz Ahmad²,

Karuppiah Kannan³

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2023

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Physical and Pharmacokinetic Characterization of Soluvec™, a novel, solvent-free Aqueous Ivermectin Formulation

Mandalaywala,

Rana,

Ramos

et al. 2023

Ther. Deliv.

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Purpose: To describe application of the Quicksol™ solvent-free approach to solubilize ivermectin (IVM). Methods: Lyophilized IVM complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD) was resolubilized in aqueous polysorbate-80, generating Soluvec™. Lyophilizate was examined by Fourier-transform infrared spectroscopy and differential scanning calorimetry; Soluvec, by dynamic light scattering. Pharmacokinetics was evaluated in dogs allocated to subcutaneous (SC) or intramuscular (IM) Soluvec or oral IVM. Results: IVM in Soluvec was tightly bound by HPβCD, forming nearly monodisperse 28 nm particles with solubility ∼2500-times that of free IVM. SC and IM Soluvec increased IVM exposure, peak IVM and extended duration of IVM exposure, versus oral dosing. Conclusion: The Quicksol method generated Soluvec, a concentrated aqueous parenteral IVM formulation with pharmacokinetic properties suitable for veterinary or human use.

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Physical and Pharmacokinetic Characterization of Soluvec™, a novel, solvent-free Aqueous Ivermectin Formulation

Mandalaywala,

Rana,

Ramos

et al. 2023

Ther. Deliv.

View full text Add to dashboard Cite

show abstract

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Pharmacokinetics of Ivermectin (Noromectin®) Following Single Dose Subcutaneous Administration in Sheep

Cited by 1 publication

References 30 publications

Physical and Pharmacokinetic Characterization of Soluvec™, a novel, solvent-free Aqueous Ivermectin Formulation

Physical and Pharmacokinetic Characterization of Soluvec™, a novel, solvent-free Aqueous Ivermectin Formulation

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